Plausible relationship between homocysteine and obesity risk via MTHFR gene: a meta-analysis of 38,317 individuals implementing Mendelian randomization

Liwan Fu,1 Ya-nan Li,1 Dongmei Luo,1,2 Shufang Deng,1 Yue-Qing Hu1,31State Key Laboratory of Genetic Engineering, Institute of Biostatistics, School of Life Sciences, Fudan University, Shanghai, People’s Republic of China; 2Department of Information and Computing Science, School o...

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Autores principales:	Fu L, Li Y, Luo D, Deng S, Hu YQ
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2019
Materias:	Homocysteine MTHFR obesity polymorphism Specialties of internal medicine RC581-951
Acceso en línea:	https://doaj.org/article/b48abecd1b184301ac6dfb236ade52c1
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spelling	oai:doaj.org-article:b48abecd1b184301ac6dfb236ade52c12021-12-02T03:18:44ZPlausible relationship between homocysteine and obesity risk via MTHFR gene: a meta-analysis of 38,317 individuals implementing Mendelian randomization1178-7007https://doaj.org/article/b48abecd1b184301ac6dfb236ade52c12019-07-01T00:00:00Zhttps://www.dovepress.com/plausible-relationship-between-homocysteine-and-obesity-risk-via-mthfr-peer-reviewed-article-DMSOhttps://doaj.org/toc/1178-7007Liwan Fu,1 Ya-nan Li,1 Dongmei Luo,1,2 Shufang Deng,1 Yue-Qing Hu1,31State Key Laboratory of Genetic Engineering, Institute of Biostatistics, School of Life Sciences, Fudan University, Shanghai, People’s Republic of China; 2Department of Information and Computing Science, School of Mathematics and Physics, Anhui University of Technology, Maanshan, Anhui, People’s Republic of China; 3Shanghai Center for Mathematical Sciences, Fudan University, Shanghai, People’s Republic of ChinaObjective: Numerous studies have explored the role of methylenetetrahydrofolate reductase gene (MTHFR) C677T polymorphism and homocysteine (Hcy) concentration in obesity, but the results are inconsistent. Hence, we performed a meta-analysis implementing Mendelian randomization approach to test the assumption that the increased Hcy concentration is plausibly related to the elevated risk of obesity.Methods: Eligible studies were selected based on several inclusion and exclusion criteria. Correlations between MTHFR C677T and obesity risk, MTHFR C677T and Hcy concentration in obesity, Hcy concentration, and obesity were estimated by ORs, effect size and standard mean difference with their corresponding 95% CIs, respectively. Furthermore, Mendelian randomization analysis was performed to estimate the relationship between Hcy level and obesity.Results: Consequently, this meta-analysis implemented with Mendelian randomization approach was conducted among 8,622 cases and 29,695 controls. The results indicated that MTHFR C677T is associated with an increased risk of obesity (for T vs C: OR=1.06, 95% CI=1.02–1.10; for TT vs CC: OR=1.13, 95% CI=1.03–1.24). Moreover, in obese subjects, the pooled Hcy concentration in individuals of TT genotype was 2.91 mmol/L (95% CI: 0.27–5.55) higher than that in individuals of CC genotype. Furthermore, the pooled Hcy concentration in subjects with obesity was 0.74 mmol/L (95% CI: 0.36–1.12) higher than that in controls. The evaluated plausible OR associated with obesity was 1.23 for 5 μmol/L Hcy level increase.Conclusions: Through this meta-analysis, we emphasize a strong relationship between Hcy level and obesity by virtue of MTHFR C677T polymorphism.Keywords: homocysteine, MTHFR, obesity, polymorphismFu LLi YLuo DDeng SHu YQDove Medical PressarticleHomocysteineMTHFRobesitypolymorphismSpecialties of internal medicineRC581-951ENDiabetes, Metabolic Syndrome and Obesity: Targets and Therapy, Vol Volume 12, Pp 1201-1212 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Homocysteine MTHFR obesity polymorphism Specialties of internal medicine RC581-951
spellingShingle	Homocysteine MTHFR obesity polymorphism Specialties of internal medicine RC581-951 Fu L Li Y Luo D Deng S Hu YQ Plausible relationship between homocysteine and obesity risk via MTHFR gene: a meta-analysis of 38,317 individuals implementing Mendelian randomization
description	Liwan Fu,1 Ya-nan Li,1 Dongmei Luo,1,2 Shufang Deng,1 Yue-Qing Hu1,31State Key Laboratory of Genetic Engineering, Institute of Biostatistics, School of Life Sciences, Fudan University, Shanghai, People’s Republic of China; 2Department of Information and Computing Science, School of Mathematics and Physics, Anhui University of Technology, Maanshan, Anhui, People’s Republic of China; 3Shanghai Center for Mathematical Sciences, Fudan University, Shanghai, People’s Republic of ChinaObjective: Numerous studies have explored the role of methylenetetrahydrofolate reductase gene (MTHFR) C677T polymorphism and homocysteine (Hcy) concentration in obesity, but the results are inconsistent. Hence, we performed a meta-analysis implementing Mendelian randomization approach to test the assumption that the increased Hcy concentration is plausibly related to the elevated risk of obesity.Methods: Eligible studies were selected based on several inclusion and exclusion criteria. Correlations between MTHFR C677T and obesity risk, MTHFR C677T and Hcy concentration in obesity, Hcy concentration, and obesity were estimated by ORs, effect size and standard mean difference with their corresponding 95% CIs, respectively. Furthermore, Mendelian randomization analysis was performed to estimate the relationship between Hcy level and obesity.Results: Consequently, this meta-analysis implemented with Mendelian randomization approach was conducted among 8,622 cases and 29,695 controls. The results indicated that MTHFR C677T is associated with an increased risk of obesity (for T vs C: OR=1.06, 95% CI=1.02–1.10; for TT vs CC: OR=1.13, 95% CI=1.03–1.24). Moreover, in obese subjects, the pooled Hcy concentration in individuals of TT genotype was 2.91 mmol/L (95% CI: 0.27–5.55) higher than that in individuals of CC genotype. Furthermore, the pooled Hcy concentration in subjects with obesity was 0.74 mmol/L (95% CI: 0.36–1.12) higher than that in controls. The evaluated plausible OR associated with obesity was 1.23 for 5 μmol/L Hcy level increase.Conclusions: Through this meta-analysis, we emphasize a strong relationship between Hcy level and obesity by virtue of MTHFR C677T polymorphism.Keywords: homocysteine, MTHFR, obesity, polymorphism
format	article
author	Fu L Li Y Luo D Deng S Hu YQ
author_facet	Fu L Li Y Luo D Deng S Hu YQ
author_sort	Fu L
title	Plausible relationship between homocysteine and obesity risk via MTHFR gene: a meta-analysis of 38,317 individuals implementing Mendelian randomization
title_short	Plausible relationship between homocysteine and obesity risk via MTHFR gene: a meta-analysis of 38,317 individuals implementing Mendelian randomization
title_full	Plausible relationship between homocysteine and obesity risk via MTHFR gene: a meta-analysis of 38,317 individuals implementing Mendelian randomization
title_fullStr	Plausible relationship between homocysteine and obesity risk via MTHFR gene: a meta-analysis of 38,317 individuals implementing Mendelian randomization
title_full_unstemmed	Plausible relationship between homocysteine and obesity risk via MTHFR gene: a meta-analysis of 38,317 individuals implementing Mendelian randomization
title_sort	plausible relationship between homocysteine and obesity risk via mthfr gene: a meta-analysis of 38,317 individuals implementing mendelian randomization
publisher	Dove Medical Press
publishDate	2019
url	https://doaj.org/article/b48abecd1b184301ac6dfb236ade52c1
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Plausible relationship between homocysteine and obesity risk via MTHFR gene: a meta-analysis of 38,317 individuals implementing Mendelian randomization

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