Cancer-associated fibroblasts induce antigen-specific deletion of CD8 + T Cells to protect tumour cells

Tumours employ a variety of strategies to induce immune suppression. Here the authors show that cancer-associated fibroblasts process and cross-present tumour-antigens to T-cells resulting in antigen-specific T cell death and dysfunction via upregulation of both cell death and immune checkpoint sign...

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Autores principales:	Matthew A. Lakins, Ehsan Ghorani, Hafsa Munir, Carla P. Martins, Jacqueline D. Shields
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/b48c058284114b0fae05f95b3bfc6c35
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spelling	oai:doaj.org-article:b48c058284114b0fae05f95b3bfc6c352021-12-02T15:34:50ZCancer-associated fibroblasts induce antigen-specific deletion of CD8 + T Cells to protect tumour cells10.1038/s41467-018-03347-02041-1723https://doaj.org/article/b48c058284114b0fae05f95b3bfc6c352018-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-03347-0https://doaj.org/toc/2041-1723Tumours employ a variety of strategies to induce immune suppression. Here the authors show that cancer-associated fibroblasts process and cross-present tumour-antigens to T-cells resulting in antigen-specific T cell death and dysfunction via upregulation of both cell death and immune checkpoint signals.Matthew A. LakinsEhsan GhoraniHafsa MunirCarla P. MartinsJacqueline D. ShieldsNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-9 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Matthew A. Lakins Ehsan Ghorani Hafsa Munir Carla P. Martins Jacqueline D. Shields Cancer-associated fibroblasts induce antigen-specific deletion of CD8 + T Cells to protect tumour cells
description	Tumours employ a variety of strategies to induce immune suppression. Here the authors show that cancer-associated fibroblasts process and cross-present tumour-antigens to T-cells resulting in antigen-specific T cell death and dysfunction via upregulation of both cell death and immune checkpoint signals.
format	article
author	Matthew A. Lakins Ehsan Ghorani Hafsa Munir Carla P. Martins Jacqueline D. Shields
author_facet	Matthew A. Lakins Ehsan Ghorani Hafsa Munir Carla P. Martins Jacqueline D. Shields
author_sort	Matthew A. Lakins
title	Cancer-associated fibroblasts induce antigen-specific deletion of CD8 + T Cells to protect tumour cells
title_short	Cancer-associated fibroblasts induce antigen-specific deletion of CD8 + T Cells to protect tumour cells
title_full	Cancer-associated fibroblasts induce antigen-specific deletion of CD8 + T Cells to protect tumour cells
title_fullStr	Cancer-associated fibroblasts induce antigen-specific deletion of CD8 + T Cells to protect tumour cells
title_full_unstemmed	Cancer-associated fibroblasts induce antigen-specific deletion of CD8 + T Cells to protect tumour cells
title_sort	cancer-associated fibroblasts induce antigen-specific deletion of cd8 + t cells to protect tumour cells
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/b48c058284114b0fae05f95b3bfc6c35
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Cancer-associated fibroblasts induce antigen-specific deletion of CD8 + T Cells to protect tumour cells

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