Cancer-associated fibroblasts induce antigen-specific deletion of CD8 + T Cells to protect tumour cells

Cancer-associated fibroblasts induce antigen-specific deletion of CD8 + T Cells to protect tumour cells

Tumours employ a variety of strategies to induce immune suppression. Here the authors show that cancer-associated fibroblasts process and cross-present tumour-antigens to T-cells resulting in antigen-specific T cell death and dysfunction via upregulation of both cell death and immune checkpoint sign...

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Autores principales: Matthew A. Lakins, Ehsan Ghorani, Hafsa Munir, Carla P. Martins, Jacqueline D. Shields
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
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Science
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Acceso en línea:https://doaj.org/article/b48c058284114b0fae05f95b3bfc6c35
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