The effect of HIV-hepatitis C co-infection on bone mineral density and fracture: a meta-analysis.

The effect of HIV-hepatitis C co-infection on bone mineral density and fracture: a meta-analysis.

<h4>Objective</h4>There is a variable body of evidence on adverse bone outcomes in HIV patients co-infected with hepatitis C virus (HCV). We examined the association of HIV/HCV co-infection on osteoporosis or osteopenia (reduced bone mineral density; BMD) and fracture.<h4>Design<...

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Autores principales: Tyler J O'Neill, Laura Rivera, Vladi Struchkov, Ahmad Zaheen, Hla-Hla Thein
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Publicado: Public Library of Science (PLoS) 2014
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spelling oai:doaj.org-article:b48f79d6cf6448bc977ce17ca31379f02021-11-25T06:08:08ZThe effect of HIV-hepatitis C co-infection on bone mineral density and fracture: a meta-analysis.1932-620310.1371/journal.pone.0101493https://doaj.org/article/b48f79d6cf6448bc977ce17ca31379f02014-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/25033046/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Objective</h4>There is a variable body of evidence on adverse bone outcomes in HIV patients co-infected with hepatitis C virus (HCV). We examined the association of HIV/HCV co-infection on osteoporosis or osteopenia (reduced bone mineral density; BMD) and fracture.<h4>Design</h4>Systematic review and random effects meta-analyses.<h4>Methods</h4>A systematic literature search was conducted for articles published in English up to 1 April 2013. All studies reporting either BMD (g/cm2, or as a T-score) or incident fractures in HIV/HCV co-infected patients compared to either HIV mono-infected or HIV/HCV uninfected/seronegative controls were included. Random effects meta-analyses estimated the pooled odds ratio (OR) and the relative risk (RR) and associated 95% confidence intervals (CI).<h4>Results</h4>Thirteen eligible publications (BMD N = 6; Fracture = 7) of 2,064 identified were included with a total of 427,352 subjects. No publications reported data on HCV mono-infected controls. Meta-analysis of cross-sectional studies confirmed that low bone mineral density was increasingly prevalent among co-infected patients compared to HIV mono-infected controls (pooled OR 1.98, 95% CI 1.18, 3.31) but not those uninfected (pooled OR 1.47, 95% CI 0.78, 2.78). Significant association between co-infection and fracture was found compared to HIV mono-infected from cohort and case-control studies (pooled RR 1.57, 95% CI 1.33, 1.86) and compared to HIV/HCV uninfected from cohort (pooled RR 2.46, 95% CI 1.03, 3.88) and cross-sectional studies (pooled OR 2.30, 95% CI 2.09, 2.23).<h4>Conclusions</h4>The associations of co-infection with prevalent low BMD and risk of fracture are confirmed in this meta-analysis. Although the mechanisms of HIV/HCV co-infection's effect on BMD and fracture are not well understood, there is evidence to suggest that adverse outcomes among HIV/HCV co-infected patients are substantial.Tyler J O'NeillLaura RiveraVladi StruchkovAhmad ZaheenHla-Hla TheinPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 9, Iss 7, p e101493 (2014)
institution DOAJ
collection DOAJ
language EN
topic Medicine
R
Science
Q
spellingShingle Medicine
R
Science
Q
Tyler J O'Neill
Laura Rivera
Vladi Struchkov
Ahmad Zaheen
Hla-Hla Thein
The effect of HIV-hepatitis C co-infection on bone mineral density and fracture: a meta-analysis.
description <h4>Objective</h4>There is a variable body of evidence on adverse bone outcomes in HIV patients co-infected with hepatitis C virus (HCV). We examined the association of HIV/HCV co-infection on osteoporosis or osteopenia (reduced bone mineral density; BMD) and fracture.<h4>Design</h4>Systematic review and random effects meta-analyses.<h4>Methods</h4>A systematic literature search was conducted for articles published in English up to 1 April 2013. All studies reporting either BMD (g/cm2, or as a T-score) or incident fractures in HIV/HCV co-infected patients compared to either HIV mono-infected or HIV/HCV uninfected/seronegative controls were included. Random effects meta-analyses estimated the pooled odds ratio (OR) and the relative risk (RR) and associated 95% confidence intervals (CI).<h4>Results</h4>Thirteen eligible publications (BMD N = 6; Fracture = 7) of 2,064 identified were included with a total of 427,352 subjects. No publications reported data on HCV mono-infected controls. Meta-analysis of cross-sectional studies confirmed that low bone mineral density was increasingly prevalent among co-infected patients compared to HIV mono-infected controls (pooled OR 1.98, 95% CI 1.18, 3.31) but not those uninfected (pooled OR 1.47, 95% CI 0.78, 2.78). Significant association between co-infection and fracture was found compared to HIV mono-infected from cohort and case-control studies (pooled RR 1.57, 95% CI 1.33, 1.86) and compared to HIV/HCV uninfected from cohort (pooled RR 2.46, 95% CI 1.03, 3.88) and cross-sectional studies (pooled OR 2.30, 95% CI 2.09, 2.23).<h4>Conclusions</h4>The associations of co-infection with prevalent low BMD and risk of fracture are confirmed in this meta-analysis. Although the mechanisms of HIV/HCV co-infection's effect on BMD and fracture are not well understood, there is evidence to suggest that adverse outcomes among HIV/HCV co-infected patients are substantial.
format article
author Tyler J O'Neill
Laura Rivera
Vladi Struchkov
Ahmad Zaheen
Hla-Hla Thein
author_facet Tyler J O'Neill
Laura Rivera
Vladi Struchkov
Ahmad Zaheen
Hla-Hla Thein
author_sort Tyler J O'Neill
title The effect of HIV-hepatitis C co-infection on bone mineral density and fracture: a meta-analysis.
title_short The effect of HIV-hepatitis C co-infection on bone mineral density and fracture: a meta-analysis.
title_full The effect of HIV-hepatitis C co-infection on bone mineral density and fracture: a meta-analysis.
title_fullStr The effect of HIV-hepatitis C co-infection on bone mineral density and fracture: a meta-analysis.
title_full_unstemmed The effect of HIV-hepatitis C co-infection on bone mineral density and fracture: a meta-analysis.
title_sort effect of hiv-hepatitis c co-infection on bone mineral density and fracture: a meta-analysis.
publisher Public Library of Science (PLoS)
publishDate 2014
url https://doaj.org/article/b48f79d6cf6448bc977ce17ca31379f0
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