EGFR may couple moderate alcohol consumption to increased breast cancer risk

Christopher P Mill1, Julia A Chester2, David J Riese II11Purdue University School of Pharmacy, Purdue University Center for Cancer Research, 2Purdue University Department of Psychological Sciences, West Lafayette, IN, USAAbstract: Alcohol consumption is an established risk factor for breast cancer....

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Autores principales:	Christopher P Mill, Julia A Chester, David J Riese II
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2009
Materias:	Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/b490206e9dfa422583462a98071e66b9
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spelling	oai:doaj.org-article:b490206e9dfa422583462a98071e66b92021-12-02T02:58:44ZEGFR may couple moderate alcohol consumption to increased breast cancer risk1179-1314https://doaj.org/article/b490206e9dfa422583462a98071e66b92009-10-01T00:00:00Zhttp://www.dovepress.com/egfr-may-couple-moderate-alcohol-consumption-to-increased-breast-cance-a3607https://doaj.org/toc/1179-1314Christopher P Mill1, Julia A Chester2, David J Riese II11Purdue University School of Pharmacy, Purdue University Center for Cancer Research, 2Purdue University Department of Psychological Sciences, West Lafayette, IN, USAAbstract: Alcohol consumption is an established risk factor for breast cancer. Nonetheless, the mechanism by which alcohol contributes to breast tumor initiation or progression has yet to be definitively established. Studies using cultured human tumor cell lines have identified signaling molecules that may contribute to the effects of alcohol, including reactive oxygen species and other ethanol metabolites, matrix metalloproteases, the ErbB2/Her2/Neu receptor tyrosine kinase, cytoplasmic protein kinases, adenylate cyclase, E-cadherins, estrogen receptor, and a variety of transcription factors. Emerging data suggest that the epidermal growth factor receptor (EGFR) tyrosine kinase may contribute to breast cancer genesis and progression. Here we integrate these findings and propose three mechanisms by which alcohol contributes to breast cancer. A common feature of these mechanisms is increased EGFR signaling. Finally, we discuss how these mechanisms suggest strategies for addressing the risks associated with alcohol consumption.Keywords: alcohol, breast cancer risk factor, EGF receptor, matrix metalloprotease Christopher P MillJulia A ChesterDavid J Riese IIDove Medical PressarticleNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENBreast Cancer: Targets and Therapy, Vol 2009, Iss default, Pp 31-38 (2009)
institution	DOAJ
collection	DOAJ
language	EN
topic	Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Christopher P Mill Julia A Chester David J Riese II EGFR may couple moderate alcohol consumption to increased breast cancer risk
description	Christopher P Mill1, Julia A Chester2, David J Riese II11Purdue University School of Pharmacy, Purdue University Center for Cancer Research, 2Purdue University Department of Psychological Sciences, West Lafayette, IN, USAAbstract: Alcohol consumption is an established risk factor for breast cancer. Nonetheless, the mechanism by which alcohol contributes to breast tumor initiation or progression has yet to be definitively established. Studies using cultured human tumor cell lines have identified signaling molecules that may contribute to the effects of alcohol, including reactive oxygen species and other ethanol metabolites, matrix metalloproteases, the ErbB2/Her2/Neu receptor tyrosine kinase, cytoplasmic protein kinases, adenylate cyclase, E-cadherins, estrogen receptor, and a variety of transcription factors. Emerging data suggest that the epidermal growth factor receptor (EGFR) tyrosine kinase may contribute to breast cancer genesis and progression. Here we integrate these findings and propose three mechanisms by which alcohol contributes to breast cancer. A common feature of these mechanisms is increased EGFR signaling. Finally, we discuss how these mechanisms suggest strategies for addressing the risks associated with alcohol consumption.Keywords: alcohol, breast cancer risk factor, EGF receptor, matrix metalloprotease
format	article
author	Christopher P Mill Julia A Chester David J Riese II
author_facet	Christopher P Mill Julia A Chester David J Riese II
author_sort	Christopher P Mill
title	EGFR may couple moderate alcohol consumption to increased breast cancer risk
title_short	EGFR may couple moderate alcohol consumption to increased breast cancer risk
title_full	EGFR may couple moderate alcohol consumption to increased breast cancer risk
title_fullStr	EGFR may couple moderate alcohol consumption to increased breast cancer risk
title_full_unstemmed	EGFR may couple moderate alcohol consumption to increased breast cancer risk
title_sort	egfr may couple moderate alcohol consumption to increased breast cancer risk
publisher	Dove Medical Press
publishDate	2009
url	https://doaj.org/article/b490206e9dfa422583462a98071e66b9
work_keys_str_mv	AT christopherpmill egfrmaycouplemoderatealcoholconsumptiontoincreasedbreastcancerrisk AT juliaachester egfrmaycouplemoderatealcoholconsumptiontoincreasedbreastcancerrisk AT davidjrieseii egfrmaycouplemoderatealcoholconsumptiontoincreasedbreastcancerrisk
_version_	1718402065113284608

EGFR may couple moderate alcohol consumption to increased breast cancer risk

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