The prevalence and clinical features associated of hypothyroidism among Thai systemic sclerosis patients

Abstract Thyroid disease, particularly hypothyroidism, has been reported in systemic sclerosis (SSc). Some clinical features of SSc can also present in hypothyroidism. Our aims were to determine the prevalence of, and describe clinical features associated with, hypothyroidism in SSc patients. We con...

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Autores principales:	Yathao Paolee, Chingching Foocharoen, Suranut Charoensri, Mayfong Mayxay, Ajanee Mahakkanukrauh, Siraphop Suwannaroj, Ratanavadee Nanagara
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/b493fd2e8b7944c0b46e67094c8c9d3c
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spelling	oai:doaj.org-article:b493fd2e8b7944c0b46e67094c8c9d3c2021-12-02T16:50:24ZThe prevalence and clinical features associated of hypothyroidism among Thai systemic sclerosis patients10.1038/s41598-021-94371-62045-2322https://doaj.org/article/b493fd2e8b7944c0b46e67094c8c9d3c2021-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-94371-6https://doaj.org/toc/2045-2322Abstract Thyroid disease, particularly hypothyroidism, has been reported in systemic sclerosis (SSc). Some clinical features of SSc can also present in hypothyroidism. Our aims were to determine the prevalence of, and describe clinical features associated with, hypothyroidism in SSc patients. We conducted a historical cohort study of adult SSc patients who underwent screening thyroid function tests at the Scleroderma Clinic, Khon Kaen University, Thailand, between 2009 and 2018. The patients who had any thyroid disorders before the onset of SSc and were diagnosed as an overlap syndrome were excluded. A total of 200 SSc were included according to sample size calculation, among whom the female to male ratio was 2:1. The majority of cases (137; 69.5%) were diffuse cutaneous SSc subset. The mean age was 55.8 ± 10.7 years and the median duration of disease 4.9 (IQR 1.6–9.9) years. Of the total, 9 had primary hypothyroidism (prevalence 4.5%; 95%CI 2.1–8.4) and 22 had subclinical hypothyroidism (prevalence 11%; 95%CI 7.0–16.2). Of the latter 22, 71% had dcSSc. Logistic regression analysis indicated that unexplained anemia was significantly associated with either subclinical hypothyroid or hypothyroidism (OR 2.74; 95% CI 1.17–6.47), whereas Raynaud’s phenomenon had a negative association (OR 0.28; 95% CI 0.11–0.66). Neither severity of skin tightness nor internal organ involvement were associated with hypothyroidism among SSc patients. Clinical-subclinical hypothyroidism is uncommon among SSc patients, it is frequently associated with anemia, and less so Raynaud’s phenomenon. Clinical-subclinical hypothyroidism should thus be considered in cases of unexplained anemia in SSc patients.Yathao PaoleeChingching FoocharoenSuranut CharoensriMayfong MayxayAjanee MahakkanukrauhSiraphop SuwannarojRatanavadee NanagaraNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-7 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Yathao Paolee Chingching Foocharoen Suranut Charoensri Mayfong Mayxay Ajanee Mahakkanukrauh Siraphop Suwannaroj Ratanavadee Nanagara The prevalence and clinical features associated of hypothyroidism among Thai systemic sclerosis patients
description	Abstract Thyroid disease, particularly hypothyroidism, has been reported in systemic sclerosis (SSc). Some clinical features of SSc can also present in hypothyroidism. Our aims were to determine the prevalence of, and describe clinical features associated with, hypothyroidism in SSc patients. We conducted a historical cohort study of adult SSc patients who underwent screening thyroid function tests at the Scleroderma Clinic, Khon Kaen University, Thailand, between 2009 and 2018. The patients who had any thyroid disorders before the onset of SSc and were diagnosed as an overlap syndrome were excluded. A total of 200 SSc were included according to sample size calculation, among whom the female to male ratio was 2:1. The majority of cases (137; 69.5%) were diffuse cutaneous SSc subset. The mean age was 55.8 ± 10.7 years and the median duration of disease 4.9 (IQR 1.6–9.9) years. Of the total, 9 had primary hypothyroidism (prevalence 4.5%; 95%CI 2.1–8.4) and 22 had subclinical hypothyroidism (prevalence 11%; 95%CI 7.0–16.2). Of the latter 22, 71% had dcSSc. Logistic regression analysis indicated that unexplained anemia was significantly associated with either subclinical hypothyroid or hypothyroidism (OR 2.74; 95% CI 1.17–6.47), whereas Raynaud’s phenomenon had a negative association (OR 0.28; 95% CI 0.11–0.66). Neither severity of skin tightness nor internal organ involvement were associated with hypothyroidism among SSc patients. Clinical-subclinical hypothyroidism is uncommon among SSc patients, it is frequently associated with anemia, and less so Raynaud’s phenomenon. Clinical-subclinical hypothyroidism should thus be considered in cases of unexplained anemia in SSc patients.
format	article
author	Yathao Paolee Chingching Foocharoen Suranut Charoensri Mayfong Mayxay Ajanee Mahakkanukrauh Siraphop Suwannaroj Ratanavadee Nanagara
author_facet	Yathao Paolee Chingching Foocharoen Suranut Charoensri Mayfong Mayxay Ajanee Mahakkanukrauh Siraphop Suwannaroj Ratanavadee Nanagara
author_sort	Yathao Paolee
title	The prevalence and clinical features associated of hypothyroidism among Thai systemic sclerosis patients
title_short	The prevalence and clinical features associated of hypothyroidism among Thai systemic sclerosis patients
title_full	The prevalence and clinical features associated of hypothyroidism among Thai systemic sclerosis patients
title_fullStr	The prevalence and clinical features associated of hypothyroidism among Thai systemic sclerosis patients
title_full_unstemmed	The prevalence and clinical features associated of hypothyroidism among Thai systemic sclerosis patients
title_sort	prevalence and clinical features associated of hypothyroidism among thai systemic sclerosis patients
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/b493fd2e8b7944c0b46e67094c8c9d3c
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The prevalence and clinical features associated of hypothyroidism among Thai systemic sclerosis patients

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