Six-month incidence and persistence of oral HPV infection in HIV-negative and HIV-infected men who have sex with men.
<h4>Objectives</h4>Our aim was to assess incidence and persistence of oral HPV infection in HIV-negative and HIV-infected men who have sex with men (MSM).<h4>Methods</h4>MSM aged ≥18 years were included in Amsterdam (the Netherlands) in 2010-2011, and followed up 6 months lat...
Guardado en:
| Autores principales: | , , , , , , , , , , , |
|---|---|
| Formato: | article |
| Lenguaje: | EN |
| Publicado: |
Public Library of Science (PLoS)
2014
|
| Materias: | |
| Acceso en línea: | https://doaj.org/article/b49a9ec9ae90452f9495a3b7c2cede4f |
| Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
| id |
oai:doaj.org-article:b49a9ec9ae90452f9495a3b7c2cede4f |
|---|---|
| record_format |
dspace |
| spelling |
oai:doaj.org-article:b49a9ec9ae90452f9495a3b7c2cede4f2021-11-18T08:17:10ZSix-month incidence and persistence of oral HPV infection in HIV-negative and HIV-infected men who have sex with men.1932-620310.1371/journal.pone.0098955https://doaj.org/article/b49a9ec9ae90452f9495a3b7c2cede4f2014-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24896848/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Objectives</h4>Our aim was to assess incidence and persistence of oral HPV infection in HIV-negative and HIV-infected men who have sex with men (MSM).<h4>Methods</h4>MSM aged ≥18 years were included in Amsterdam (the Netherlands) in 2010-2011, and followed up 6 months later. Participants completed risk factor questionnaires. HPV DNA was analyzed in oral-rinse and gargle specimens using the SPF10-PCR DEIA/LiPA25 system (version 1). A subset of oral samples was subjected to SPF10 sequencing to identify additional HPV types. Multivariable logistic regression analyses using generalized estimating equations (GEE) were performed to assess determinants for oral high-risk HPV incidence and persistence.<h4>Results</h4>689/795 participant MSM provided both baseline and 6-month data. Baseline prevalence of high-risk HPV was 9.4% in HIV-negative and 23.9% in HIV-infected MSM (P<0.001). 56/689 MSM acquired ≥1 high-risk HPV infection (6-month incidence 8.1%; 95%CI 6.2-10.4%); incidence was 4.1% in HIV-negative and 14.1% in HIV-infected MSM (P<0.001). HIV infection and recent use of cannabis were both independently associated with high-risk HPV incidence. Persistent high-risk HPV was observed in 48/130 (36.9%) infections.<h4>Conclusion</h4>Incidence of oral high-risk HPV infection in MSM is substantial, and is associated with HIV infection. Over a third of HPV infections persisted over a 6-month period.Sofie H MooijHein J BootArjen G C L SpeksnijderChris J L M MeijerAudrey J KingDominique W M VerhagenHenry J C de VriesWim G V QuintAnco MolijnMaurits N C de KoningMarianne A B van der SandeMaarten F Schim van der LoeffPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 9, Iss 6, p e98955 (2014) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Medicine R Science Q |
| spellingShingle |
Medicine R Science Q Sofie H Mooij Hein J Boot Arjen G C L Speksnijder Chris J L M Meijer Audrey J King Dominique W M Verhagen Henry J C de Vries Wim G V Quint Anco Molijn Maurits N C de Koning Marianne A B van der Sande Maarten F Schim van der Loeff Six-month incidence and persistence of oral HPV infection in HIV-negative and HIV-infected men who have sex with men. |
| description |
<h4>Objectives</h4>Our aim was to assess incidence and persistence of oral HPV infection in HIV-negative and HIV-infected men who have sex with men (MSM).<h4>Methods</h4>MSM aged ≥18 years were included in Amsterdam (the Netherlands) in 2010-2011, and followed up 6 months later. Participants completed risk factor questionnaires. HPV DNA was analyzed in oral-rinse and gargle specimens using the SPF10-PCR DEIA/LiPA25 system (version 1). A subset of oral samples was subjected to SPF10 sequencing to identify additional HPV types. Multivariable logistic regression analyses using generalized estimating equations (GEE) were performed to assess determinants for oral high-risk HPV incidence and persistence.<h4>Results</h4>689/795 participant MSM provided both baseline and 6-month data. Baseline prevalence of high-risk HPV was 9.4% in HIV-negative and 23.9% in HIV-infected MSM (P<0.001). 56/689 MSM acquired ≥1 high-risk HPV infection (6-month incidence 8.1%; 95%CI 6.2-10.4%); incidence was 4.1% in HIV-negative and 14.1% in HIV-infected MSM (P<0.001). HIV infection and recent use of cannabis were both independently associated with high-risk HPV incidence. Persistent high-risk HPV was observed in 48/130 (36.9%) infections.<h4>Conclusion</h4>Incidence of oral high-risk HPV infection in MSM is substantial, and is associated with HIV infection. Over a third of HPV infections persisted over a 6-month period. |
| format |
article |
| author |
Sofie H Mooij Hein J Boot Arjen G C L Speksnijder Chris J L M Meijer Audrey J King Dominique W M Verhagen Henry J C de Vries Wim G V Quint Anco Molijn Maurits N C de Koning Marianne A B van der Sande Maarten F Schim van der Loeff |
| author_facet |
Sofie H Mooij Hein J Boot Arjen G C L Speksnijder Chris J L M Meijer Audrey J King Dominique W M Verhagen Henry J C de Vries Wim G V Quint Anco Molijn Maurits N C de Koning Marianne A B van der Sande Maarten F Schim van der Loeff |
| author_sort |
Sofie H Mooij |
| title |
Six-month incidence and persistence of oral HPV infection in HIV-negative and HIV-infected men who have sex with men. |
| title_short |
Six-month incidence and persistence of oral HPV infection in HIV-negative and HIV-infected men who have sex with men. |
| title_full |
Six-month incidence and persistence of oral HPV infection in HIV-negative and HIV-infected men who have sex with men. |
| title_fullStr |
Six-month incidence and persistence of oral HPV infection in HIV-negative and HIV-infected men who have sex with men. |
| title_full_unstemmed |
Six-month incidence and persistence of oral HPV infection in HIV-negative and HIV-infected men who have sex with men. |
| title_sort |
six-month incidence and persistence of oral hpv infection in hiv-negative and hiv-infected men who have sex with men. |
| publisher |
Public Library of Science (PLoS) |
| publishDate |
2014 |
| url |
https://doaj.org/article/b49a9ec9ae90452f9495a3b7c2cede4f |
| work_keys_str_mv |
AT sofiehmooij sixmonthincidenceandpersistenceoforalhpvinfectioninhivnegativeandhivinfectedmenwhohavesexwithmen AT heinjboot sixmonthincidenceandpersistenceoforalhpvinfectioninhivnegativeandhivinfectedmenwhohavesexwithmen AT arjengclspeksnijder sixmonthincidenceandpersistenceoforalhpvinfectioninhivnegativeandhivinfectedmenwhohavesexwithmen AT chrisjlmmeijer sixmonthincidenceandpersistenceoforalhpvinfectioninhivnegativeandhivinfectedmenwhohavesexwithmen AT audreyjking sixmonthincidenceandpersistenceoforalhpvinfectioninhivnegativeandhivinfectedmenwhohavesexwithmen AT dominiquewmverhagen sixmonthincidenceandpersistenceoforalhpvinfectioninhivnegativeandhivinfectedmenwhohavesexwithmen AT henryjcdevries sixmonthincidenceandpersistenceoforalhpvinfectioninhivnegativeandhivinfectedmenwhohavesexwithmen AT wimgvquint sixmonthincidenceandpersistenceoforalhpvinfectioninhivnegativeandhivinfectedmenwhohavesexwithmen AT ancomolijn sixmonthincidenceandpersistenceoforalhpvinfectioninhivnegativeandhivinfectedmenwhohavesexwithmen AT mauritsncdekoning sixmonthincidenceandpersistenceoforalhpvinfectioninhivnegativeandhivinfectedmenwhohavesexwithmen AT marianneabvandersande sixmonthincidenceandpersistenceoforalhpvinfectioninhivnegativeandhivinfectedmenwhohavesexwithmen AT maartenfschimvanderloeff sixmonthincidenceandpersistenceoforalhpvinfectioninhivnegativeandhivinfectedmenwhohavesexwithmen |
| _version_ |
1718422005944942592 |