Hashimoto encephalopathy with high plasma monoamine metabolite levels: a case report

Sho Horikoshi,1,2 Itaru Miura,2 Yasuto Kunii,3 Satoko Asano,4 Keiko Kanno-Nozaki,2 Hirobumi Mashiko,5 Hirooki Yabe2 1Department of Neuropsychiatry, Hoshi General Hospital, 2Department of Neuropsychiatry, Fukushima Medical University School of Medicine, 3Department of Neuropsychiatry, Fukushima Medi...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Horikoshi S, Miura I, Kunii Y, Asano S, Kanno-Nozaki K, Mashiko H, Yabe H
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2017
Materias:	Hashimoto encephalopathy monoamine metabolite homovanillic acid; 3-methoxy-4hydroxyphenylglycol symptomatic psychosis Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/b49fe687ec7d4281900f9a81ac53603a
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:b49fe687ec7d4281900f9a81ac53603a
record_format	dspace
spelling	oai:doaj.org-article:b49fe687ec7d4281900f9a81ac53603a2021-12-02T03:26:34ZHashimoto encephalopathy with high plasma monoamine metabolite levels: a case report1178-2021https://doaj.org/article/b49fe687ec7d4281900f9a81ac53603a2017-04-01T00:00:00Zhttps://www.dovepress.com/hashimoto-encephalopathy-with-high-plasma-monoamine-metabolite-levels--peer-reviewed-article-NDThttps://doaj.org/toc/1178-2021Sho Horikoshi,1,2 Itaru Miura,2 Yasuto Kunii,3 Satoko Asano,4 Keiko Kanno-Nozaki,2 Hirobumi Mashiko,5 Hirooki Yabe2 1Department of Neuropsychiatry, Hoshi General Hospital, 2Department of Neuropsychiatry, Fukushima Medical University School of Medicine, 3Department of Neuropsychiatry, Fukushima Medical University School of Aizu Medical Center, 4Department of Neuropsychiatry, Japan Red Cross Fukushima Hospital, 5Department of Neuropsychiatry, Fukushima Prefectural General Rehabilitation Center, Fukushima, Japan Abstract: Hashimoto encephalopathy (HE) is believed to be an immune-mediated disorder associated with Hashimoto’s thyroiditis. It was suggested that neuropsychiatric symptoms, the presence of antithyroid antibody, and good response to steroids were important for the diagnosis of HE. It has been reported that homovanillic acid (HVA) and 3-methoxy-4-hydroxyphenylglycol (MHPG), which are monoamine metabolites of dopamine and noradrenaline, respectively, are the possible biomarkers of neuropsychiatric diseases. We report a case of Hashimoto encephalopathy, in which we longitudinally measured the plasma levels of monoamine metabolites. A 52-year-old woman developed acute psychosis, and was admitted to the psychiatric ward of our hospital due to psychotic state, 6 days after a traffic accident. An extensive evaluation showed no remarkable findings, except an increase in antithyroglobulin antibodies. Plasma levels of HVA and MHPG were extremely high at 66.5 and 41.8 ng/mL, respectively. On day 16, 50 mg/day oral prednisolone was administered, which improved her psychotic symptoms. Plasma levels of HVA and MHPG decreased to 7.2 and 9.9 ng/mL, respectively, on day 19. After the temporary worsening of psychosis and increase in plasma levels of HVA and MHPG, the dosage of prednisolone was tapered and low-dose risperidone was started. Her psychiatric symptoms gradually improved and plasma monoamine metabolite levels decreased again (HVA: 17.9 ng/mL; MHPG: 7.7 ng/mL). Although autoimmune mechanism has been suggested to be involved in HE, neural mechanism and pathogenesis of HE remain unknown. Our findings suggest that monoaminergic neural activity might be associated with psychotic symptoms in patients with HE and plasma levels of monoamine metabolites might be useful as state markers. Keywords: Hashimoto encephalopathy, monoamine metabolite, homovanillic acid, 3-methoxy-4-hydroxyphenylglycol, symptomatic psychosisHorikoshi SMiura IKunii YAsano SKanno-Nozaki KMashiko HYabe HDove Medical PressarticleHashimoto encephalopathymonoamine metabolitehomovanillic acid; 3-methoxy-4hydroxyphenylglycolsymptomatic psychosisNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol Volume 13, Pp 1043-1045 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Hashimoto encephalopathy monoamine metabolite homovanillic acid; 3-methoxy-4hydroxyphenylglycol symptomatic psychosis Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	Hashimoto encephalopathy monoamine metabolite homovanillic acid; 3-methoxy-4hydroxyphenylglycol symptomatic psychosis Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Horikoshi S Miura I Kunii Y Asano S Kanno-Nozaki K Mashiko H Yabe H Hashimoto encephalopathy with high plasma monoamine metabolite levels: a case report
description	Sho Horikoshi,1,2 Itaru Miura,2 Yasuto Kunii,3 Satoko Asano,4 Keiko Kanno-Nozaki,2 Hirobumi Mashiko,5 Hirooki Yabe2 1Department of Neuropsychiatry, Hoshi General Hospital, 2Department of Neuropsychiatry, Fukushima Medical University School of Medicine, 3Department of Neuropsychiatry, Fukushima Medical University School of Aizu Medical Center, 4Department of Neuropsychiatry, Japan Red Cross Fukushima Hospital, 5Department of Neuropsychiatry, Fukushima Prefectural General Rehabilitation Center, Fukushima, Japan Abstract: Hashimoto encephalopathy (HE) is believed to be an immune-mediated disorder associated with Hashimoto’s thyroiditis. It was suggested that neuropsychiatric symptoms, the presence of antithyroid antibody, and good response to steroids were important for the diagnosis of HE. It has been reported that homovanillic acid (HVA) and 3-methoxy-4-hydroxyphenylglycol (MHPG), which are monoamine metabolites of dopamine and noradrenaline, respectively, are the possible biomarkers of neuropsychiatric diseases. We report a case of Hashimoto encephalopathy, in which we longitudinally measured the plasma levels of monoamine metabolites. A 52-year-old woman developed acute psychosis, and was admitted to the psychiatric ward of our hospital due to psychotic state, 6 days after a traffic accident. An extensive evaluation showed no remarkable findings, except an increase in antithyroglobulin antibodies. Plasma levels of HVA and MHPG were extremely high at 66.5 and 41.8 ng/mL, respectively. On day 16, 50 mg/day oral prednisolone was administered, which improved her psychotic symptoms. Plasma levels of HVA and MHPG decreased to 7.2 and 9.9 ng/mL, respectively, on day 19. After the temporary worsening of psychosis and increase in plasma levels of HVA and MHPG, the dosage of prednisolone was tapered and low-dose risperidone was started. Her psychiatric symptoms gradually improved and plasma monoamine metabolite levels decreased again (HVA: 17.9 ng/mL; MHPG: 7.7 ng/mL). Although autoimmune mechanism has been suggested to be involved in HE, neural mechanism and pathogenesis of HE remain unknown. Our findings suggest that monoaminergic neural activity might be associated with psychotic symptoms in patients with HE and plasma levels of monoamine metabolites might be useful as state markers. Keywords: Hashimoto encephalopathy, monoamine metabolite, homovanillic acid, 3-methoxy-4-hydroxyphenylglycol, symptomatic psychosis
format	article
author	Horikoshi S Miura I Kunii Y Asano S Kanno-Nozaki K Mashiko H Yabe H
author_facet	Horikoshi S Miura I Kunii Y Asano S Kanno-Nozaki K Mashiko H Yabe H
author_sort	Horikoshi S
title	Hashimoto encephalopathy with high plasma monoamine metabolite levels: a case report
title_short	Hashimoto encephalopathy with high plasma monoamine metabolite levels: a case report
title_full	Hashimoto encephalopathy with high plasma monoamine metabolite levels: a case report
title_fullStr	Hashimoto encephalopathy with high plasma monoamine metabolite levels: a case report
title_full_unstemmed	Hashimoto encephalopathy with high plasma monoamine metabolite levels: a case report
title_sort	hashimoto encephalopathy with high plasma monoamine metabolite levels: a case report
publisher	Dove Medical Press
publishDate	2017
url	https://doaj.org/article/b49fe687ec7d4281900f9a81ac53603a
work_keys_str_mv	AT horikoshis hashimotoencephalopathywithhighplasmamonoaminemetabolitelevelsacasereport AT miurai hashimotoencephalopathywithhighplasmamonoaminemetabolitelevelsacasereport AT kuniiy hashimotoencephalopathywithhighplasmamonoaminemetabolitelevelsacasereport AT asanos hashimotoencephalopathywithhighplasmamonoaminemetabolitelevelsacasereport AT kannonozakik hashimotoencephalopathywithhighplasmamonoaminemetabolitelevelsacasereport AT mashikoh hashimotoencephalopathywithhighplasmamonoaminemetabolitelevelsacasereport AT yabeh hashimotoencephalopathywithhighplasmamonoaminemetabolitelevelsacasereport
_version_	1718401753294045184

Hashimoto encephalopathy with high plasma monoamine metabolite levels: a case report

Ejemplares similares