Obesity, Insulin Resistance, and Type 2 Diabetes: Associations and Therapeutic Implications

Yohannes Tsegyie Wondmkun Department of Pharmacology and Clinical Pharmacy, School of Pharmacy, College of Health Sciences, Addis Ababa University, Addis Ababa, EthiopiaCorrespondence: Yohannes Tsegyie Wondmkun Department of Pharmacology and Clinical Pharmacy, School of Pharmacy, College of Health S...

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Autor principal:	Wondmkun YT
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2020
Materias:	obesity insulin insulin resistance type 2 diabetes mellitus Specialties of internal medicine RC581-951
Acceso en línea:	https://doaj.org/article/b4a6202929514210bc2a00f9afdc63dc
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spelling	oai:doaj.org-article:b4a6202929514210bc2a00f9afdc63dc2021-12-02T13:01:39ZObesity, Insulin Resistance, and Type 2 Diabetes: Associations and Therapeutic Implications1178-7007https://doaj.org/article/b4a6202929514210bc2a00f9afdc63dc2020-10-01T00:00:00Zhttps://www.dovepress.com/obesity-insulin-resistance-and-type-2-diabetes-associations-and-therap-peer-reviewed-article-DMSOhttps://doaj.org/toc/1178-7007Yohannes Tsegyie Wondmkun Department of Pharmacology and Clinical Pharmacy, School of Pharmacy, College of Health Sciences, Addis Ababa University, Addis Ababa, EthiopiaCorrespondence: Yohannes Tsegyie Wondmkun Department of Pharmacology and Clinical Pharmacy, School of Pharmacy, College of Health SciencesAddis Ababa University, P.O. Box 1176, Addis Ababa, EthiopiaEmail yonitse2015@gmail.comAbstract: Obesity is a triggering factor for diabetes associated with insulin resistance. In individuals who are obese, higher amounts of non-esterified fatty acids, glycerol, hormones, and pro-inflammatory cytokines that could participate in the development of insulin resistance are released by adipose tissue. Besides, endoplasmic reticulum stress, adipose tissue hypoxia, oxidative stress, lipodystrophy, and genetic background have a role in insulin resistance. However, no effective drug therapy was developed for type 2 diabetes mellitus targeting these physiological factors. This is might be due to a lack of agreement on the comprehensive mechanism of insulin resistance. Therefore, this review assesses the cellular components of each physiologic and pathophysiologic factors that are involved in obesity associated insulin resistance, and may encourage further drug development in this field.Keywords: obesity, insulin, insulin resistance, type 2 diabetes mellitusWondmkun YTDove Medical Pressarticleobesityinsulininsulin resistancetype 2 diabetes mellitusSpecialties of internal medicineRC581-951ENDiabetes, Metabolic Syndrome and Obesity: Targets and Therapy, Vol Volume 13, Pp 3611-3616 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	obesity insulin insulin resistance type 2 diabetes mellitus Specialties of internal medicine RC581-951
spellingShingle	obesity insulin insulin resistance type 2 diabetes mellitus Specialties of internal medicine RC581-951 Wondmkun YT Obesity, Insulin Resistance, and Type 2 Diabetes: Associations and Therapeutic Implications
description	Yohannes Tsegyie Wondmkun Department of Pharmacology and Clinical Pharmacy, School of Pharmacy, College of Health Sciences, Addis Ababa University, Addis Ababa, EthiopiaCorrespondence: Yohannes Tsegyie Wondmkun Department of Pharmacology and Clinical Pharmacy, School of Pharmacy, College of Health SciencesAddis Ababa University, P.O. Box 1176, Addis Ababa, EthiopiaEmail yonitse2015@gmail.comAbstract: Obesity is a triggering factor for diabetes associated with insulin resistance. In individuals who are obese, higher amounts of non-esterified fatty acids, glycerol, hormones, and pro-inflammatory cytokines that could participate in the development of insulin resistance are released by adipose tissue. Besides, endoplasmic reticulum stress, adipose tissue hypoxia, oxidative stress, lipodystrophy, and genetic background have a role in insulin resistance. However, no effective drug therapy was developed for type 2 diabetes mellitus targeting these physiological factors. This is might be due to a lack of agreement on the comprehensive mechanism of insulin resistance. Therefore, this review assesses the cellular components of each physiologic and pathophysiologic factors that are involved in obesity associated insulin resistance, and may encourage further drug development in this field.Keywords: obesity, insulin, insulin resistance, type 2 diabetes mellitus
format	article
author	Wondmkun YT
author_facet	Wondmkun YT
author_sort	Wondmkun YT
title	Obesity, Insulin Resistance, and Type 2 Diabetes: Associations and Therapeutic Implications
title_short	Obesity, Insulin Resistance, and Type 2 Diabetes: Associations and Therapeutic Implications
title_full	Obesity, Insulin Resistance, and Type 2 Diabetes: Associations and Therapeutic Implications
title_fullStr	Obesity, Insulin Resistance, and Type 2 Diabetes: Associations and Therapeutic Implications
title_full_unstemmed	Obesity, Insulin Resistance, and Type 2 Diabetes: Associations and Therapeutic Implications
title_sort	obesity, insulin resistance, and type 2 diabetes: associations and therapeutic implications
publisher	Dove Medical Press
publishDate	2020
url	https://doaj.org/article/b4a6202929514210bc2a00f9afdc63dc
work_keys_str_mv	AT wondmkunyt obesityinsulinresistanceandtype2diabetesassociationsandtherapeuticimplications
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Obesity, Insulin Resistance, and Type 2 Diabetes: Associations and Therapeutic Implications

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