Improved phylogenetic resolution for Y-chromosome Haplogroup O2a1c-002611

Abstract Y-chromosome Haplogroup O2a1c-002611 is one of the dominant lineages of East Asians and Southeast Asians. However, its internal phylogeny remains insufficiently investigated. In this study, we genotyped 89 new highly informative single nucleotide polymorphisms (SNPs) in 305 individuals with...

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Autores principales:	Xiaotian Yao, Senwei Tang, Beilei Bian, Xiaoli Wu, Gang Chen, Chuan-Chao Wang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/b4aa750490df4cfbb6085934f2cb5d16
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spelling	oai:doaj.org-article:b4aa750490df4cfbb6085934f2cb5d162021-12-02T12:30:44ZImproved phylogenetic resolution for Y-chromosome Haplogroup O2a1c-00261110.1038/s41598-017-01340-z2045-2322https://doaj.org/article/b4aa750490df4cfbb6085934f2cb5d162017-04-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-01340-zhttps://doaj.org/toc/2045-2322Abstract Y-chromosome Haplogroup O2a1c-002611 is one of the dominant lineages of East Asians and Southeast Asians. However, its internal phylogeny remains insufficiently investigated. In this study, we genotyped 89 new highly informative single nucleotide polymorphisms (SNPs) in 305 individuals with Haplogroup O2a1c-002611 identified from 2139 Han Chinese males. Two major branches were identified, O2a1c1-F18 and O2a1c2-L133.2 and the first was further divided into two main subclades, O2a1c1a-F11 and O2a1c1b-F449, accounting for 11.13% and 2.20% of Han Chinese, respectively. In Haplogroup O2a1c1a-F11, we also determined seven sublineages with quite different frequency distributions in Han Chinese ranging from 0.187% to 3.553%, implying they might have different demographic history. The reconstructed haplogroup tree for all the major clades within Haplogroup O2a1c-002611 permits better resolution of male lineages in population studies of East Asia and Southeast Asia. The dataset generated in the present study are also valuable for forensic identification and paternity tests in China.Xiaotian YaoSenwei TangBeilei BianXiaoli WuGang ChenChuan-Chao WangNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-5 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Xiaotian Yao Senwei Tang Beilei Bian Xiaoli Wu Gang Chen Chuan-Chao Wang Improved phylogenetic resolution for Y-chromosome Haplogroup O2a1c-002611
description	Abstract Y-chromosome Haplogroup O2a1c-002611 is one of the dominant lineages of East Asians and Southeast Asians. However, its internal phylogeny remains insufficiently investigated. In this study, we genotyped 89 new highly informative single nucleotide polymorphisms (SNPs) in 305 individuals with Haplogroup O2a1c-002611 identified from 2139 Han Chinese males. Two major branches were identified, O2a1c1-F18 and O2a1c2-L133.2 and the first was further divided into two main subclades, O2a1c1a-F11 and O2a1c1b-F449, accounting for 11.13% and 2.20% of Han Chinese, respectively. In Haplogroup O2a1c1a-F11, we also determined seven sublineages with quite different frequency distributions in Han Chinese ranging from 0.187% to 3.553%, implying they might have different demographic history. The reconstructed haplogroup tree for all the major clades within Haplogroup O2a1c-002611 permits better resolution of male lineages in population studies of East Asia and Southeast Asia. The dataset generated in the present study are also valuable for forensic identification and paternity tests in China.
format	article
author	Xiaotian Yao Senwei Tang Beilei Bian Xiaoli Wu Gang Chen Chuan-Chao Wang
author_facet	Xiaotian Yao Senwei Tang Beilei Bian Xiaoli Wu Gang Chen Chuan-Chao Wang
author_sort	Xiaotian Yao
title	Improved phylogenetic resolution for Y-chromosome Haplogroup O2a1c-002611
title_short	Improved phylogenetic resolution for Y-chromosome Haplogroup O2a1c-002611
title_full	Improved phylogenetic resolution for Y-chromosome Haplogroup O2a1c-002611
title_fullStr	Improved phylogenetic resolution for Y-chromosome Haplogroup O2a1c-002611
title_full_unstemmed	Improved phylogenetic resolution for Y-chromosome Haplogroup O2a1c-002611
title_sort	improved phylogenetic resolution for y-chromosome haplogroup o2a1c-002611
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/b4aa750490df4cfbb6085934f2cb5d16
work_keys_str_mv	AT xiaotianyao improvedphylogeneticresolutionforychromosomehaplogroupo2a1c002611 AT senweitang improvedphylogeneticresolutionforychromosomehaplogroupo2a1c002611 AT beileibian improvedphylogeneticresolutionforychromosomehaplogroupo2a1c002611 AT xiaoliwu improvedphylogeneticresolutionforychromosomehaplogroupo2a1c002611 AT gangchen improvedphylogeneticresolutionforychromosomehaplogroupo2a1c002611 AT chuanchaowang improvedphylogeneticresolutionforychromosomehaplogroupo2a1c002611
_version_	1718394356339048448

Improved phylogenetic resolution for Y-chromosome Haplogroup O2a1c-002611

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