Bodiniosides S–Y, Seven New Triterpenoid Saponins from Elsholtzia bodinieri and Their Anti-Influenza Activities

Investigation of the n-BuOH extract of the aerial parts of Elsholtzia bodinieri led to the isolation of seven new triterpenoid saponins, Bodiniosides S–Y (1–7, resp.). Their strictures were elucidated on the basis of spectroscopic techniques,...

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Autores principales:	Linyao Yang, Jiangchao Du, Rongtao Li, Fei Yu, Jindong Zhong
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	<i>Elsholtzia bodinieri</i> triterpenoid saponins anti-influenza virus activities bodiniosides S–Y Organic chemistry QD241-441
Acceso en línea:	https://doaj.org/article/b4ab26f52e9b4f7f98318fde13d2a1ab
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spelling	oai:doaj.org-article:b4ab26f52e9b4f7f98318fde13d2a1ab2021-11-11T18:31:27ZBodiniosides S–Y, Seven New Triterpenoid Saponins from <i>Elsholtzia bodinieri</i> and Their Anti-Influenza Activities10.3390/molecules262165351420-3049https://doaj.org/article/b4ab26f52e9b4f7f98318fde13d2a1ab2021-10-01T00:00:00Zhttps://www.mdpi.com/1420-3049/26/21/6535https://doaj.org/toc/1420-3049Investigation of the n-BuOH extract of the aerial parts of <i>Elsholtzia bodinieri</i> led to the isolation of seven new triterpenoid saponins, Bodiniosides S–Y (<b>1</b>–<b>7</b>, resp.). Their strictures were elucidated on the basis of spectroscopic techniques, including HSQC, HSBC, and HSQC–TOCSY experiments, together with acid hydrolysis and GC analysis. The anti-influenza activities of compounds <b>1</b>–<b>7</b> were evaluated against A/WSN/33/2009 (H1N1) virus in MDCK cells. The results showed that compounds <b>2</b> and <b>5</b> exhibited moderate anti-influenza activities against A/WSN/33/2009 (H1N1), with inhibition rates of 35.33% and 24.08%, respectively.Linyao YangJiangchao DuRongtao LiFei YuJindong ZhongMDPI AGarticle<i>Elsholtzia bodinieri</i>triterpenoid saponinsanti-influenza virus activitiesbodiniosides S–YOrganic chemistryQD241-441ENMolecules, Vol 26, Iss 6535, p 6535 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	<i>Elsholtzia bodinieri</i> triterpenoid saponins anti-influenza virus activities bodiniosides S–Y Organic chemistry QD241-441
spellingShingle	<i>Elsholtzia bodinieri</i> triterpenoid saponins anti-influenza virus activities bodiniosides S–Y Organic chemistry QD241-441 Linyao Yang Jiangchao Du Rongtao Li Fei Yu Jindong Zhong Bodiniosides S–Y, Seven New Triterpenoid Saponins from <i>Elsholtzia bodinieri</i> and Their Anti-Influenza Activities
description	Investigation of the n-BuOH extract of the aerial parts of <i>Elsholtzia bodinieri</i> led to the isolation of seven new triterpenoid saponins, Bodiniosides S–Y (<b>1</b>–<b>7</b>, resp.). Their strictures were elucidated on the basis of spectroscopic techniques, including HSQC, HSBC, and HSQC–TOCSY experiments, together with acid hydrolysis and GC analysis. The anti-influenza activities of compounds <b>1</b>–<b>7</b> were evaluated against A/WSN/33/2009 (H1N1) virus in MDCK cells. The results showed that compounds <b>2</b> and <b>5</b> exhibited moderate anti-influenza activities against A/WSN/33/2009 (H1N1), with inhibition rates of 35.33% and 24.08%, respectively.
format	article
author	Linyao Yang Jiangchao Du Rongtao Li Fei Yu Jindong Zhong
author_facet	Linyao Yang Jiangchao Du Rongtao Li Fei Yu Jindong Zhong
author_sort	Linyao Yang
title	Bodiniosides S–Y, Seven New Triterpenoid Saponins from <i>Elsholtzia bodinieri</i> and Their Anti-Influenza Activities
title_short	Bodiniosides S–Y, Seven New Triterpenoid Saponins from <i>Elsholtzia bodinieri</i> and Their Anti-Influenza Activities
title_full	Bodiniosides S–Y, Seven New Triterpenoid Saponins from <i>Elsholtzia bodinieri</i> and Their Anti-Influenza Activities
title_fullStr	Bodiniosides S–Y, Seven New Triterpenoid Saponins from <i>Elsholtzia bodinieri</i> and Their Anti-Influenza Activities
title_full_unstemmed	Bodiniosides S–Y, Seven New Triterpenoid Saponins from <i>Elsholtzia bodinieri</i> and Their Anti-Influenza Activities
title_sort	bodiniosides s–y, seven new triterpenoid saponins from <i>elsholtzia bodinieri</i> and their anti-influenza activities
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/b4ab26f52e9b4f7f98318fde13d2a1ab
work_keys_str_mv	AT linyaoyang bodiniosidessysevennewtriterpenoidsaponinsfromielsholtziabodinieriiandtheirantiinfluenzaactivities AT jiangchaodu bodiniosidessysevennewtriterpenoidsaponinsfromielsholtziabodinieriiandtheirantiinfluenzaactivities AT rongtaoli bodiniosidessysevennewtriterpenoidsaponinsfromielsholtziabodinieriiandtheirantiinfluenzaactivities AT feiyu bodiniosidessysevennewtriterpenoidsaponinsfromielsholtziabodinieriiandtheirantiinfluenzaactivities AT jindongzhong bodiniosidessysevennewtriterpenoidsaponinsfromielsholtziabodinieriiandtheirantiinfluenzaactivities
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Bodiniosides S–Y, Seven New Triterpenoid Saponins from <i>Elsholtzia bodinieri</i> and Their Anti-Influenza Activities

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