Methylation of a CGATA element inhibits binding and regulation by GATA-1

While DNA methylation is thought to play a regulatory role, there are few examples where modification of a single CpG dinucleotide directly affects transcription factor binding. Here the authors show that methylation of a single CGATA element within the c-Kit gene inhibits binding and regulation by...

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Autores principales:	Lu Yang, Zhiliang Chen, Elizabeth S. Stout, Fabien Delerue, Lars M. Ittner, Marc R. Wilkins, Kate G. R. Quinlan, Merlin Crossley
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/b4acfc4575304524ad85c29fe8eab477
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spelling	oai:doaj.org-article:b4acfc4575304524ad85c29fe8eab4772021-12-02T14:58:44ZMethylation of a CGATA element inhibits binding and regulation by GATA-110.1038/s41467-020-16388-12041-1723https://doaj.org/article/b4acfc4575304524ad85c29fe8eab4772020-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-16388-1https://doaj.org/toc/2041-1723While DNA methylation is thought to play a regulatory role, there are few examples where modification of a single CpG dinucleotide directly affects transcription factor binding. Here the authors show that methylation of a single CGATA element within the c-Kit gene inhibits binding and regulation by erythroid transcription factor GATA-1, both in cells and in mice, suggesting that methylation at this site plays an essential role in erythropoiesis.Lu YangZhiliang ChenElizabeth S. StoutFabien DelerueLars M. IttnerMarc R. WilkinsKate G. R. QuinlanMerlin CrossleyNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-10 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Lu Yang Zhiliang Chen Elizabeth S. Stout Fabien Delerue Lars M. Ittner Marc R. Wilkins Kate G. R. Quinlan Merlin Crossley Methylation of a CGATA element inhibits binding and regulation by GATA-1
description	While DNA methylation is thought to play a regulatory role, there are few examples where modification of a single CpG dinucleotide directly affects transcription factor binding. Here the authors show that methylation of a single CGATA element within the c-Kit gene inhibits binding and regulation by erythroid transcription factor GATA-1, both in cells and in mice, suggesting that methylation at this site plays an essential role in erythropoiesis.
format	article
author	Lu Yang Zhiliang Chen Elizabeth S. Stout Fabien Delerue Lars M. Ittner Marc R. Wilkins Kate G. R. Quinlan Merlin Crossley
author_facet	Lu Yang Zhiliang Chen Elizabeth S. Stout Fabien Delerue Lars M. Ittner Marc R. Wilkins Kate G. R. Quinlan Merlin Crossley
author_sort	Lu Yang
title	Methylation of a CGATA element inhibits binding and regulation by GATA-1
title_short	Methylation of a CGATA element inhibits binding and regulation by GATA-1
title_full	Methylation of a CGATA element inhibits binding and regulation by GATA-1
title_fullStr	Methylation of a CGATA element inhibits binding and regulation by GATA-1
title_full_unstemmed	Methylation of a CGATA element inhibits binding and regulation by GATA-1
title_sort	methylation of a cgata element inhibits binding and regulation by gata-1
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/b4acfc4575304524ad85c29fe8eab477
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Methylation of a CGATA element inhibits binding and regulation by GATA-1

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