Radiation-induced DNA damage and repair effects on 3D genome organization

Genomic aberrations disrupting chromosome spatial domains can lead to disease. Here, the authors investigate the impact of DNA damage response and repair on 3D genome folding, comparing wild type cells and ataxia telangiectasia mutated patient cells, and characterise both cell type-specific and shar...

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Autores principales:	Jacob T. Sanders, Trevor F. Freeman, Yang Xu, Rosela Golloshi, Mary A. Stallard, Ashtyn M. Hill, Rebeca San Martin, Adayabalam S. Balajee, Rachel Patton McCord
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/b4ae77227af5466d8c9ab8117687906b
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spelling	oai:doaj.org-article:b4ae77227af5466d8c9ab8117687906b2021-12-02T16:56:32ZRadiation-induced DNA damage and repair effects on 3D genome organization10.1038/s41467-020-20047-w2041-1723https://doaj.org/article/b4ae77227af5466d8c9ab8117687906b2020-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-20047-whttps://doaj.org/toc/2041-1723Genomic aberrations disrupting chromosome spatial domains can lead to disease. Here, the authors investigate the impact of DNA damage response and repair on 3D genome folding, comparing wild type cells and ataxia telangiectasia mutated patient cells, and characterise both cell type-specific and shared changes to genome organization during the response to damage.Jacob T. SandersTrevor F. FreemanYang XuRosela GolloshiMary A. StallardAshtyn M. HillRebeca San MartinAdayabalam S. BalajeeRachel Patton McCordNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Jacob T. Sanders Trevor F. Freeman Yang Xu Rosela Golloshi Mary A. Stallard Ashtyn M. Hill Rebeca San Martin Adayabalam S. Balajee Rachel Patton McCord Radiation-induced DNA damage and repair effects on 3D genome organization
description	Genomic aberrations disrupting chromosome spatial domains can lead to disease. Here, the authors investigate the impact of DNA damage response and repair on 3D genome folding, comparing wild type cells and ataxia telangiectasia mutated patient cells, and characterise both cell type-specific and shared changes to genome organization during the response to damage.
format	article
author	Jacob T. Sanders Trevor F. Freeman Yang Xu Rosela Golloshi Mary A. Stallard Ashtyn M. Hill Rebeca San Martin Adayabalam S. Balajee Rachel Patton McCord
author_facet	Jacob T. Sanders Trevor F. Freeman Yang Xu Rosela Golloshi Mary A. Stallard Ashtyn M. Hill Rebeca San Martin Adayabalam S. Balajee Rachel Patton McCord
author_sort	Jacob T. Sanders
title	Radiation-induced DNA damage and repair effects on 3D genome organization
title_short	Radiation-induced DNA damage and repair effects on 3D genome organization
title_full	Radiation-induced DNA damage and repair effects on 3D genome organization
title_fullStr	Radiation-induced DNA damage and repair effects on 3D genome organization
title_full_unstemmed	Radiation-induced DNA damage and repair effects on 3D genome organization
title_sort	radiation-induced dna damage and repair effects on 3d genome organization
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/b4ae77227af5466d8c9ab8117687906b
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Radiation-induced DNA damage and repair effects on 3D genome organization

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