Comparison of Flutamide and Metformin in Overweight-Obese Women with Polycystic Ovary Syndrome Following a Hypocaloric Dieting

BACKGROUND AND OBJECTIVE: Polycystic ovary syndrome is one of the most common items in endocrine diseases and involved patients are at the risk of diabetes and atherosclerosis and cardiovascular disease. The most common clinical features of PCOS are insulin resistance, hyperandrogenemia, non ovulati...

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Autores principales:	S Esmaeilzadeh, L Ghorbani, M Sharbatdaran, A Bijani, P Sajadi
Formato:	article
Lenguaje:	EN FA
Publicado:	Babol University of Medical Sciences 2010
Materias:	polycystic ovary syndrome metformin flutamide hypocaloric diet hirsutism Medicine R Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/b4aef92ab0214a6da5fabe1a889bcd6d
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spelling	oai:doaj.org-article:b4aef92ab0214a6da5fabe1a889bcd6d2021-11-10T09:00:36ZComparison of Flutamide and Metformin in Overweight-Obese Women with Polycystic Ovary Syndrome Following a Hypocaloric Dieting1561-41072251-7170https://doaj.org/article/b4aef92ab0214a6da5fabe1a889bcd6d2010-10-01T00:00:00Zhttp://jbums.org/article-1-3661-en.htmlhttps://doaj.org/toc/1561-4107https://doaj.org/toc/2251-7170BACKGROUND AND OBJECTIVE: Polycystic ovary syndrome is one of the most common items in endocrine diseases and involved patients are at the risk of diabetes and atherosclerosis and cardiovascular disease. The most common clinical features of PCOS are insulin resistance, hyperandrogenemia, non ovulation and infertility. Since obesity is the most common cause of insulin resistance and hyperandrogenemia, so this study was designed to evaluate the effects of weight reduction and treatment with metformin and flutamide on insulin resistance indices and hyperandrogenism and lipid serum in overweight-obese PCOS patients. METHODS: This double blind clinical trial study was performed on 40 overweight-obese women with PCOS. After a one month diet, according to a control trial double blind design, the patients were randomly allocated to treatment with placebo, metformin (500mg/TDS) and flutamide (250 mg/BID) for the following 6 months while continuing hypocaloric dieting. At baseline and at the end of the study anthropometric parameters, hirsutism and menses, sex hormones, SHBG, lipid and insulin sensitivity determinations were measured and compared in two groups.FINDINGS: Metformin (12.2±6.07 kg) has a significant effect in decreasing body weight (p=0.000), BMI (p=0.000), waist circumference (p=0.000) and hip circumference (p=0.000) and hirsutism (p=0.000), total testosterone (p=0.032). Flutamide (6.5±5.1 kg) has effectively decreased body weight (p=0.000), BMI (p=0.000), waist circumference (p=0.000) and waist/hip circumference (p=0.005) and hirsutism (p=0.000), total testosterone (p =0.024), cholesterol (p=0.011) and LDL levels (p=0.013). CONCLUSION: The results of this study showed that safe drugs such as metformin and flutamide reduced in anthropometric indices and hirsutism. Metformin has been more effective in reducing weight, BMI, waist and hip circumference rather than flutamide.S EsmaeilzadehL GhorbaniM SharbatdaranA BijaniP SajadiBabol University of Medical Sciencesarticlepolycystic ovary syndromemetforminflutamidehypocaloric diethirsutismMedicineRMedicine (General)R5-920ENFAMajallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Bābul, Vol 12, Iss 4, Pp 7-13 (2010)
institution	DOAJ
collection	DOAJ
language	EN FA
topic	polycystic ovary syndrome metformin flutamide hypocaloric diet hirsutism Medicine R Medicine (General) R5-920
spellingShingle	polycystic ovary syndrome metformin flutamide hypocaloric diet hirsutism Medicine R Medicine (General) R5-920 S Esmaeilzadeh L Ghorbani M Sharbatdaran A Bijani P Sajadi Comparison of Flutamide and Metformin in Overweight-Obese Women with Polycystic Ovary Syndrome Following a Hypocaloric Dieting
description	BACKGROUND AND OBJECTIVE: Polycystic ovary syndrome is one of the most common items in endocrine diseases and involved patients are at the risk of diabetes and atherosclerosis and cardiovascular disease. The most common clinical features of PCOS are insulin resistance, hyperandrogenemia, non ovulation and infertility. Since obesity is the most common cause of insulin resistance and hyperandrogenemia, so this study was designed to evaluate the effects of weight reduction and treatment with metformin and flutamide on insulin resistance indices and hyperandrogenism and lipid serum in overweight-obese PCOS patients. METHODS: This double blind clinical trial study was performed on 40 overweight-obese women with PCOS. After a one month diet, according to a control trial double blind design, the patients were randomly allocated to treatment with placebo, metformin (500mg/TDS) and flutamide (250 mg/BID) for the following 6 months while continuing hypocaloric dieting. At baseline and at the end of the study anthropometric parameters, hirsutism and menses, sex hormones, SHBG, lipid and insulin sensitivity determinations were measured and compared in two groups.FINDINGS: Metformin (12.2±6.07 kg) has a significant effect in decreasing body weight (p=0.000), BMI (p=0.000), waist circumference (p=0.000) and hip circumference (p=0.000) and hirsutism (p=0.000), total testosterone (p=0.032). Flutamide (6.5±5.1 kg) has effectively decreased body weight (p=0.000), BMI (p=0.000), waist circumference (p=0.000) and waist/hip circumference (p=0.005) and hirsutism (p=0.000), total testosterone (p =0.024), cholesterol (p=0.011) and LDL levels (p=0.013). CONCLUSION: The results of this study showed that safe drugs such as metformin and flutamide reduced in anthropometric indices and hirsutism. Metformin has been more effective in reducing weight, BMI, waist and hip circumference rather than flutamide.
format	article
author	S Esmaeilzadeh L Ghorbani M Sharbatdaran A Bijani P Sajadi
author_facet	S Esmaeilzadeh L Ghorbani M Sharbatdaran A Bijani P Sajadi
author_sort	S Esmaeilzadeh
title	Comparison of Flutamide and Metformin in Overweight-Obese Women with Polycystic Ovary Syndrome Following a Hypocaloric Dieting
title_short	Comparison of Flutamide and Metformin in Overweight-Obese Women with Polycystic Ovary Syndrome Following a Hypocaloric Dieting
title_full	Comparison of Flutamide and Metformin in Overweight-Obese Women with Polycystic Ovary Syndrome Following a Hypocaloric Dieting
title_fullStr	Comparison of Flutamide and Metformin in Overweight-Obese Women with Polycystic Ovary Syndrome Following a Hypocaloric Dieting
title_full_unstemmed	Comparison of Flutamide and Metformin in Overweight-Obese Women with Polycystic Ovary Syndrome Following a Hypocaloric Dieting
title_sort	comparison of flutamide and metformin in overweight-obese women with polycystic ovary syndrome following a hypocaloric dieting
publisher	Babol University of Medical Sciences
publishDate	2010
url	https://doaj.org/article/b4aef92ab0214a6da5fabe1a889bcd6d
work_keys_str_mv	AT sesmaeilzadeh comparisonofflutamideandmetformininoverweightobesewomenwithpolycysticovarysyndromefollowingahypocaloricdieting AT lghorbani comparisonofflutamideandmetformininoverweightobesewomenwithpolycysticovarysyndromefollowingahypocaloricdieting AT msharbatdaran comparisonofflutamideandmetformininoverweightobesewomenwithpolycysticovarysyndromefollowingahypocaloricdieting AT abijani comparisonofflutamideandmetformininoverweightobesewomenwithpolycysticovarysyndromefollowingahypocaloricdieting AT psajadi comparisonofflutamideandmetformininoverweightobesewomenwithpolycysticovarysyndromefollowingahypocaloricdieting
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Comparison of Flutamide and Metformin in Overweight-Obese Women with Polycystic Ovary Syndrome Following a Hypocaloric Dieting

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