Proline codon pair selection determines ribosome pausing strength and translation efficiency in bacteria

Ralph Krafczyk et al. demonstrate that both proline codon usage and prolyl-tRNA abundance affect mRNA translation rates of polyproline-motifs in bacteria. These results provide additional insight into sequence-specific translation regulation.

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Autores principales:	Ralph Krafczyk, Fei Qi, Alina Sieber, Judith Mehler, Kirsten Jung, Dmitrij Frishman, Jürgen Lassak
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/b4af811cdec04b86b9f2d2ab3de7d104
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spelling	oai:doaj.org-article:b4af811cdec04b86b9f2d2ab3de7d1042021-12-02T15:52:54ZProline codon pair selection determines ribosome pausing strength and translation efficiency in bacteria10.1038/s42003-021-02115-z2399-3642https://doaj.org/article/b4af811cdec04b86b9f2d2ab3de7d1042021-05-01T00:00:00Zhttps://doi.org/10.1038/s42003-021-02115-zhttps://doaj.org/toc/2399-3642Ralph Krafczyk et al. demonstrate that both proline codon usage and prolyl-tRNA abundance affect mRNA translation rates of polyproline-motifs in bacteria. These results provide additional insight into sequence-specific translation regulation.Ralph KrafczykFei QiAlina SieberJudith MehlerKirsten JungDmitrij FrishmanJürgen LassakNature PortfolioarticleBiology (General)QH301-705.5ENCommunications Biology, Vol 4, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Ralph Krafczyk Fei Qi Alina Sieber Judith Mehler Kirsten Jung Dmitrij Frishman Jürgen Lassak Proline codon pair selection determines ribosome pausing strength and translation efficiency in bacteria
description	Ralph Krafczyk et al. demonstrate that both proline codon usage and prolyl-tRNA abundance affect mRNA translation rates of polyproline-motifs in bacteria. These results provide additional insight into sequence-specific translation regulation.
format	article
author	Ralph Krafczyk Fei Qi Alina Sieber Judith Mehler Kirsten Jung Dmitrij Frishman Jürgen Lassak
author_facet	Ralph Krafczyk Fei Qi Alina Sieber Judith Mehler Kirsten Jung Dmitrij Frishman Jürgen Lassak
author_sort	Ralph Krafczyk
title	Proline codon pair selection determines ribosome pausing strength and translation efficiency in bacteria
title_short	Proline codon pair selection determines ribosome pausing strength and translation efficiency in bacteria
title_full	Proline codon pair selection determines ribosome pausing strength and translation efficiency in bacteria
title_fullStr	Proline codon pair selection determines ribosome pausing strength and translation efficiency in bacteria
title_full_unstemmed	Proline codon pair selection determines ribosome pausing strength and translation efficiency in bacteria
title_sort	proline codon pair selection determines ribosome pausing strength and translation efficiency in bacteria
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/b4af811cdec04b86b9f2d2ab3de7d104
work_keys_str_mv	AT ralphkrafczyk prolinecodonpairselectiondeterminesribosomepausingstrengthandtranslationefficiencyinbacteria AT feiqi prolinecodonpairselectiondeterminesribosomepausingstrengthandtranslationefficiencyinbacteria AT alinasieber prolinecodonpairselectiondeterminesribosomepausingstrengthandtranslationefficiencyinbacteria AT judithmehler prolinecodonpairselectiondeterminesribosomepausingstrengthandtranslationefficiencyinbacteria AT kirstenjung prolinecodonpairselectiondeterminesribosomepausingstrengthandtranslationefficiencyinbacteria AT dmitrijfrishman prolinecodonpairselectiondeterminesribosomepausingstrengthandtranslationefficiencyinbacteria AT jurgenlassak prolinecodonpairselectiondeterminesribosomepausingstrengthandtranslationefficiencyinbacteria
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Proline codon pair selection determines ribosome pausing strength and translation efficiency in bacteria

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