Antisense oligonucleotide modulation of non-productive alternative splicing upregulates gene expression

Restoration of normal gene expression is one way to treat monogenic disorders. Here the authors target naturally occurring non-productive alternative splicing using antisense oligonucleotides to promote the production of functional proteins.

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Autores principales:	Kian Huat Lim, Zhou Han, Hyun Yong Jeon, Jacob Kach, Enxuan Jing, Sebastien Weyn-Vanhentenryck, Mikaela Downs, Anna Corrionero, Raymond Oh, Juergen Scharner, Aditya Venkatesh, Sophina Ji, Gene Liau, Barry Ticho, Huw Nash, Isabel Aznarez
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/b4b17242c1b24dc9905cc03dd97077f2
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spelling	oai:doaj.org-article:b4b17242c1b24dc9905cc03dd97077f22021-12-02T15:23:00ZAntisense oligonucleotide modulation of non-productive alternative splicing upregulates gene expression10.1038/s41467-020-17093-92041-1723https://doaj.org/article/b4b17242c1b24dc9905cc03dd97077f22020-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-17093-9https://doaj.org/toc/2041-1723Restoration of normal gene expression is one way to treat monogenic disorders. Here the authors target naturally occurring non-productive alternative splicing using antisense oligonucleotides to promote the production of functional proteins.Kian Huat LimZhou HanHyun Yong JeonJacob KachEnxuan JingSebastien Weyn-VanhentenryckMikaela DownsAnna CorrioneroRaymond OhJuergen ScharnerAditya VenkateshSophina JiGene LiauBarry TichoHuw NashIsabel AznarezNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Kian Huat Lim Zhou Han Hyun Yong Jeon Jacob Kach Enxuan Jing Sebastien Weyn-Vanhentenryck Mikaela Downs Anna Corrionero Raymond Oh Juergen Scharner Aditya Venkatesh Sophina Ji Gene Liau Barry Ticho Huw Nash Isabel Aznarez Antisense oligonucleotide modulation of non-productive alternative splicing upregulates gene expression
description	Restoration of normal gene expression is one way to treat monogenic disorders. Here the authors target naturally occurring non-productive alternative splicing using antisense oligonucleotides to promote the production of functional proteins.
format	article
author	Kian Huat Lim Zhou Han Hyun Yong Jeon Jacob Kach Enxuan Jing Sebastien Weyn-Vanhentenryck Mikaela Downs Anna Corrionero Raymond Oh Juergen Scharner Aditya Venkatesh Sophina Ji Gene Liau Barry Ticho Huw Nash Isabel Aznarez
author_facet	Kian Huat Lim Zhou Han Hyun Yong Jeon Jacob Kach Enxuan Jing Sebastien Weyn-Vanhentenryck Mikaela Downs Anna Corrionero Raymond Oh Juergen Scharner Aditya Venkatesh Sophina Ji Gene Liau Barry Ticho Huw Nash Isabel Aznarez
author_sort	Kian Huat Lim
title	Antisense oligonucleotide modulation of non-productive alternative splicing upregulates gene expression
title_short	Antisense oligonucleotide modulation of non-productive alternative splicing upregulates gene expression
title_full	Antisense oligonucleotide modulation of non-productive alternative splicing upregulates gene expression
title_fullStr	Antisense oligonucleotide modulation of non-productive alternative splicing upregulates gene expression
title_full_unstemmed	Antisense oligonucleotide modulation of non-productive alternative splicing upregulates gene expression
title_sort	antisense oligonucleotide modulation of non-productive alternative splicing upregulates gene expression
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/b4b17242c1b24dc9905cc03dd97077f2
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Antisense oligonucleotide modulation of non-productive alternative splicing upregulates gene expression

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