Sero-catalytic and Antibody Acquisition Models to Estimate Differing Malaria Transmission Intensities in Western Kenya

Abstract We sought to identify a subset of Plasmodium falciparum antibody targets that would inform monitoring efforts needed to eliminate malaria in high transmission settings. IgG antibodies to 28 recombinant Pf antigens were measured in residents of two communities in western Kenya examined in 20...

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Autores principales:	Grace E. Weber, Michael T. White, Anna Babakhanyan, Peter Odada Sumba, John Vulule, Dylan Ely, Chandy John, Evelina Angov, David Lanar, Sheetij Dutta, David L. Narum, Toshihiro Horii, Alan Cowman, James Beeson, Joseph Smith, James W. Kazura, Arlene E. Dent
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/b4b23d2c9c8c47a69405060fca7a2b2d
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spelling	oai:doaj.org-article:b4b23d2c9c8c47a69405060fca7a2b2d2021-12-02T15:05:41ZSero-catalytic and Antibody Acquisition Models to Estimate Differing Malaria Transmission Intensities in Western Kenya10.1038/s41598-017-17084-92045-2322https://doaj.org/article/b4b23d2c9c8c47a69405060fca7a2b2d2017-12-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-17084-9https://doaj.org/toc/2045-2322Abstract We sought to identify a subset of Plasmodium falciparum antibody targets that would inform monitoring efforts needed to eliminate malaria in high transmission settings. IgG antibodies to 28 recombinant Pf antigens were measured in residents of two communities in western Kenya examined in 2003 and 2013, when the respective prevalence of asymptomatic parasitemia among children was 81 and 15 percent by microscopy. Annual seroconversion rates based on a sero-catalytic model that dichotomised antibody values to negative versus positive showed that rates were higher in 2003 than 2013 for 1 pre-erythrocytic and 7 blood-stage antigens. Antibody acquisition models that considered antibody levels as continuous variables showed that age-related antibody levels to Circumsporozoite Protein and 10 merozoite proteins increased at different rates with age in 2003 versus 2013. Both models found that antibodies to 5 proteins of the Merozoite Surface Protein 1 complex were differentially acquired between the cohorts, and that changes in antibody levels to Apical Membrane Antigen 1 suggested a decrease in transmission that occurred ~10 years before 2013. Further studies evaluating antibodies to this subset of Pf antigens as biomarkers of malaria exposure and naturally acquired immunity are warranted in endemic settings where transmission has been reduced but persists.Grace E. WeberMichael T. WhiteAnna BabakhanyanPeter Odada SumbaJohn VululeDylan ElyChandy JohnEvelina AngovDavid LanarSheetij DuttaDavid L. NarumToshihiro HoriiAlan CowmanJames BeesonJoseph SmithJames W. KazuraArlene E. DentNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-12 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Grace E. Weber Michael T. White Anna Babakhanyan Peter Odada Sumba John Vulule Dylan Ely Chandy John Evelina Angov David Lanar Sheetij Dutta David L. Narum Toshihiro Horii Alan Cowman James Beeson Joseph Smith James W. Kazura Arlene E. Dent Sero-catalytic and Antibody Acquisition Models to Estimate Differing Malaria Transmission Intensities in Western Kenya
description	Abstract We sought to identify a subset of Plasmodium falciparum antibody targets that would inform monitoring efforts needed to eliminate malaria in high transmission settings. IgG antibodies to 28 recombinant Pf antigens were measured in residents of two communities in western Kenya examined in 2003 and 2013, when the respective prevalence of asymptomatic parasitemia among children was 81 and 15 percent by microscopy. Annual seroconversion rates based on a sero-catalytic model that dichotomised antibody values to negative versus positive showed that rates were higher in 2003 than 2013 for 1 pre-erythrocytic and 7 blood-stage antigens. Antibody acquisition models that considered antibody levels as continuous variables showed that age-related antibody levels to Circumsporozoite Protein and 10 merozoite proteins increased at different rates with age in 2003 versus 2013. Both models found that antibodies to 5 proteins of the Merozoite Surface Protein 1 complex were differentially acquired between the cohorts, and that changes in antibody levels to Apical Membrane Antigen 1 suggested a decrease in transmission that occurred ~10 years before 2013. Further studies evaluating antibodies to this subset of Pf antigens as biomarkers of malaria exposure and naturally acquired immunity are warranted in endemic settings where transmission has been reduced but persists.
format	article
author	Grace E. Weber Michael T. White Anna Babakhanyan Peter Odada Sumba John Vulule Dylan Ely Chandy John Evelina Angov David Lanar Sheetij Dutta David L. Narum Toshihiro Horii Alan Cowman James Beeson Joseph Smith James W. Kazura Arlene E. Dent
author_facet	Grace E. Weber Michael T. White Anna Babakhanyan Peter Odada Sumba John Vulule Dylan Ely Chandy John Evelina Angov David Lanar Sheetij Dutta David L. Narum Toshihiro Horii Alan Cowman James Beeson Joseph Smith James W. Kazura Arlene E. Dent
author_sort	Grace E. Weber
title	Sero-catalytic and Antibody Acquisition Models to Estimate Differing Malaria Transmission Intensities in Western Kenya
title_short	Sero-catalytic and Antibody Acquisition Models to Estimate Differing Malaria Transmission Intensities in Western Kenya
title_full	Sero-catalytic and Antibody Acquisition Models to Estimate Differing Malaria Transmission Intensities in Western Kenya
title_fullStr	Sero-catalytic and Antibody Acquisition Models to Estimate Differing Malaria Transmission Intensities in Western Kenya
title_full_unstemmed	Sero-catalytic and Antibody Acquisition Models to Estimate Differing Malaria Transmission Intensities in Western Kenya
title_sort	sero-catalytic and antibody acquisition models to estimate differing malaria transmission intensities in western kenya
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/b4b23d2c9c8c47a69405060fca7a2b2d
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Sero-catalytic and Antibody Acquisition Models to Estimate Differing Malaria Transmission Intensities in Western Kenya

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