Aronia Upregulates Myogenic Differentiation and Augments Muscle Mass and Function Through Muscle Metabolism

Black chokeberry or aronia (the fruit of Aronia melanocarpa) has been reported to having pharmacological activities against metabolic syndrome, such as hypertension, obesity, diabetes, and pro-inflammatory conditions. However, the effects of aronia on myogenic differentiation and muscle homoeostasis...

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Autores principales:	Chae-Eun Yun, Hyun-Kyung So, Tuan Anh Vuong, Myung Woo Na, Subin Anh, Hyo-Keun Lee, Ki Hyun Kim, Jong-Sun Kang, Gyu-Un Bae, Sang-Jin Lee
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	aronia melanocarpa muscle atrophy muscle differentiation muscle mass and function myofiber types Nutrition. Foods and food supply TX341-641
Acceso en línea:	https://doaj.org/article/b4b6ead80ec74b5d9ad4ae15290e3a9d
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spelling	oai:doaj.org-article:b4b6ead80ec74b5d9ad4ae15290e3a9d2021-11-30T14:13:16ZAronia Upregulates Myogenic Differentiation and Augments Muscle Mass and Function Through Muscle Metabolism2296-861X10.3389/fnut.2021.753643https://doaj.org/article/b4b6ead80ec74b5d9ad4ae15290e3a9d2021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fnut.2021.753643/fullhttps://doaj.org/toc/2296-861XBlack chokeberry or aronia (the fruit of Aronia melanocarpa) has been reported to having pharmacological activities against metabolic syndrome, such as hypertension, obesity, diabetes, and pro-inflammatory conditions. However, the effects of aronia on myogenic differentiation and muscle homoeostasis are uncharacterized. In this study, we investigated the effects of aronia (black chokeberry) on myogenic differentiation and muscle metabolic functions in young mice. Aronia extract (AR) promotes myogenic differentiation and elevates the formation of multinucleated myotubes through Akt activation. AR protects dexamethasone (DEX)-induced myotube atrophy through inhibition of muscle-specific ubiquitin ligases mediated by Akt activation. The treatment with AR increases muscle mass and strength in mice without cardiac hypertrophy. AR treatment enhances both oxidative and glycolytic myofibers and muscle metabolism with elevated mitochondrial genes and glucose metabolism-related genes. Furthermore, AR-fed muscle fibers display increased levels of total OxPHOS and myoglobin proteins. Taken together, AR enhances myogenic differentiation and improves muscle mass and function, suggesting that AR has a promising potential as a nutraceutical remedy to intervene in muscle weakness and atrophy.Chae-Eun YunChae-Eun YunHyun-Kyung SoHyun-Kyung SoHyun-Kyung SoTuan Anh VuongMyung Woo NaSubin AnhSubin AnhHyo-Keun LeeKi Hyun KimJong-Sun KangJong-Sun KangGyu-Un BaeSang-Jin LeeFrontiers Media S.A.articlearonia melanocarpamuscle atrophymuscle differentiationmuscle mass and functionmyofiber typesNutrition. Foods and food supplyTX341-641ENFrontiers in Nutrition, Vol 8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	aronia melanocarpa muscle atrophy muscle differentiation muscle mass and function myofiber types Nutrition. Foods and food supply TX341-641
spellingShingle	aronia melanocarpa muscle atrophy muscle differentiation muscle mass and function myofiber types Nutrition. Foods and food supply TX341-641 Chae-Eun Yun Chae-Eun Yun Hyun-Kyung So Hyun-Kyung So Hyun-Kyung So Tuan Anh Vuong Myung Woo Na Subin Anh Subin Anh Hyo-Keun Lee Ki Hyun Kim Jong-Sun Kang Jong-Sun Kang Gyu-Un Bae Sang-Jin Lee Aronia Upregulates Myogenic Differentiation and Augments Muscle Mass and Function Through Muscle Metabolism
description	Black chokeberry or aronia (the fruit of Aronia melanocarpa) has been reported to having pharmacological activities against metabolic syndrome, such as hypertension, obesity, diabetes, and pro-inflammatory conditions. However, the effects of aronia on myogenic differentiation and muscle homoeostasis are uncharacterized. In this study, we investigated the effects of aronia (black chokeberry) on myogenic differentiation and muscle metabolic functions in young mice. Aronia extract (AR) promotes myogenic differentiation and elevates the formation of multinucleated myotubes through Akt activation. AR protects dexamethasone (DEX)-induced myotube atrophy through inhibition of muscle-specific ubiquitin ligases mediated by Akt activation. The treatment with AR increases muscle mass and strength in mice without cardiac hypertrophy. AR treatment enhances both oxidative and glycolytic myofibers and muscle metabolism with elevated mitochondrial genes and glucose metabolism-related genes. Furthermore, AR-fed muscle fibers display increased levels of total OxPHOS and myoglobin proteins. Taken together, AR enhances myogenic differentiation and improves muscle mass and function, suggesting that AR has a promising potential as a nutraceutical remedy to intervene in muscle weakness and atrophy.
format	article
author	Chae-Eun Yun Chae-Eun Yun Hyun-Kyung So Hyun-Kyung So Hyun-Kyung So Tuan Anh Vuong Myung Woo Na Subin Anh Subin Anh Hyo-Keun Lee Ki Hyun Kim Jong-Sun Kang Jong-Sun Kang Gyu-Un Bae Sang-Jin Lee
author_facet	Chae-Eun Yun Chae-Eun Yun Hyun-Kyung So Hyun-Kyung So Hyun-Kyung So Tuan Anh Vuong Myung Woo Na Subin Anh Subin Anh Hyo-Keun Lee Ki Hyun Kim Jong-Sun Kang Jong-Sun Kang Gyu-Un Bae Sang-Jin Lee
author_sort	Chae-Eun Yun
title	Aronia Upregulates Myogenic Differentiation and Augments Muscle Mass and Function Through Muscle Metabolism
title_short	Aronia Upregulates Myogenic Differentiation and Augments Muscle Mass and Function Through Muscle Metabolism
title_full	Aronia Upregulates Myogenic Differentiation and Augments Muscle Mass and Function Through Muscle Metabolism
title_fullStr	Aronia Upregulates Myogenic Differentiation and Augments Muscle Mass and Function Through Muscle Metabolism
title_full_unstemmed	Aronia Upregulates Myogenic Differentiation and Augments Muscle Mass and Function Through Muscle Metabolism
title_sort	aronia upregulates myogenic differentiation and augments muscle mass and function through muscle metabolism
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/b4b6ead80ec74b5d9ad4ae15290e3a9d
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Aronia Upregulates Myogenic Differentiation and Augments Muscle Mass and Function Through Muscle Metabolism

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