The molecular basis of the genesis of basal tone in internal anal sphincter

The molecular basis of the genesis of basal tone in internal anal sphincter

The molecular basis of the basal tone generated by internal anal sphincters (IAS) is largely unknown. Here, the authors show that the tone arises from a global rise in intracellular Ca2+ in smooth muscle cells via a Ryanodine receptor-TMEM16A-L-type Ca2+channel-MLC kinase pathway, suggesting a poten...

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Autores principales: Cheng-Hai Zhang, Pei Wang, Dong-Hai Liu, Cai-Ping Chen, Wei Zhao, Xin Chen, Chen Chen, Wei-Qi He, Yan-Ning Qiao, Tao Tao, Jie Sun, Ya-Jing Peng, Ping Lu, Kaizhi Zheng, Siobhan M. Craige, Lawrence M. Lifshitz, John F. Keaney Jr, Kevin E. Fogarty, Ronghua ZhuGe, Min-Sheng Zhu
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2016
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Science
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Acceso en línea:https://doaj.org/article/b4b7ab0c59cd416bb5911aec0550d29f
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Sumario:The molecular basis of the basal tone generated by internal anal sphincters (IAS) is largely unknown. Here, the authors show that the tone arises from a global rise in intracellular Ca2+ in smooth muscle cells via a Ryanodine receptor-TMEM16A-L-type Ca2+channel-MLC kinase pathway, suggesting a potential therapy for IAS motility disorders.

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