The molecular basis of the genesis of basal tone in internal anal sphincter

The molecular basis of the genesis of basal tone in internal anal sphincter

The molecular basis of the basal tone generated by internal anal sphincters (IAS) is largely unknown. Here, the authors show that the tone arises from a global rise in intracellular Ca2+ in smooth muscle cells via a Ryanodine receptor-TMEM16A-L-type Ca2+channel-MLC kinase pathway, suggesting a poten...

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Autores principales: Cheng-Hai Zhang, Pei Wang, Dong-Hai Liu, Cai-Ping Chen, Wei Zhao, Xin Chen, Chen Chen, Wei-Qi He, Yan-Ning Qiao, Tao Tao, Jie Sun, Ya-Jing Peng, Ping Lu, Kaizhi Zheng, Siobhan M. Craige, Lawrence M. Lifshitz, John F. Keaney Jr, Kevin E. Fogarty, Ronghua ZhuGe, Min-Sheng Zhu
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Lenguaje:EN
Publicado: Nature Portfolio 2016
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Acceso en línea:https://doaj.org/article/b4b7ab0c59cd416bb5911aec0550d29f
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spelling oai:doaj.org-article:b4b7ab0c59cd416bb5911aec0550d29f2021-12-02T14:40:15ZThe molecular basis of the genesis of basal tone in internal anal sphincter10.1038/ncomms113582041-1723https://doaj.org/article/b4b7ab0c59cd416bb5911aec0550d29f2016-04-01T00:00:00Zhttps://doi.org/10.1038/ncomms11358https://doaj.org/toc/2041-1723The molecular basis of the basal tone generated by internal anal sphincters (IAS) is largely unknown. Here, the authors show that the tone arises from a global rise in intracellular Ca2+ in smooth muscle cells via a Ryanodine receptor-TMEM16A-L-type Ca2+channel-MLC kinase pathway, suggesting a potential therapy for IAS motility disorders.Cheng-Hai ZhangPei WangDong-Hai LiuCai-Ping ChenWei ZhaoXin ChenChen ChenWei-Qi HeYan-Ning QiaoTao TaoJie SunYa-Jing PengPing LuKaizhi ZhengSiobhan M. CraigeLawrence M. LifshitzJohn F. Keaney JrKevin E. FogartyRonghua ZhuGeMin-Sheng ZhuNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-10 (2016)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Cheng-Hai Zhang
Pei Wang
Dong-Hai Liu
Cai-Ping Chen
Wei Zhao
Xin Chen
Chen Chen
Wei-Qi He
Yan-Ning Qiao
Tao Tao
Jie Sun
Ya-Jing Peng
Ping Lu
Kaizhi Zheng
Siobhan M. Craige
Lawrence M. Lifshitz
John F. Keaney Jr
Kevin E. Fogarty
Ronghua ZhuGe
Min-Sheng Zhu
The molecular basis of the genesis of basal tone in internal anal sphincter
description The molecular basis of the basal tone generated by internal anal sphincters (IAS) is largely unknown. Here, the authors show that the tone arises from a global rise in intracellular Ca2+ in smooth muscle cells via a Ryanodine receptor-TMEM16A-L-type Ca2+channel-MLC kinase pathway, suggesting a potential therapy for IAS motility disorders.
format article
author Cheng-Hai Zhang
Pei Wang
Dong-Hai Liu
Cai-Ping Chen
Wei Zhao
Xin Chen
Chen Chen
Wei-Qi He
Yan-Ning Qiao
Tao Tao
Jie Sun
Ya-Jing Peng
Ping Lu
Kaizhi Zheng
Siobhan M. Craige
Lawrence M. Lifshitz
John F. Keaney Jr
Kevin E. Fogarty
Ronghua ZhuGe
Min-Sheng Zhu
author_facet Cheng-Hai Zhang
Pei Wang
Dong-Hai Liu
Cai-Ping Chen
Wei Zhao
Xin Chen
Chen Chen
Wei-Qi He
Yan-Ning Qiao
Tao Tao
Jie Sun
Ya-Jing Peng
Ping Lu
Kaizhi Zheng
Siobhan M. Craige
Lawrence M. Lifshitz
John F. Keaney Jr
Kevin E. Fogarty
Ronghua ZhuGe
Min-Sheng Zhu
author_sort Cheng-Hai Zhang
title The molecular basis of the genesis of basal tone in internal anal sphincter
title_short The molecular basis of the genesis of basal tone in internal anal sphincter
title_full The molecular basis of the genesis of basal tone in internal anal sphincter
title_fullStr The molecular basis of the genesis of basal tone in internal anal sphincter
title_full_unstemmed The molecular basis of the genesis of basal tone in internal anal sphincter
title_sort molecular basis of the genesis of basal tone in internal anal sphincter
publisher Nature Portfolio
publishDate 2016
url https://doaj.org/article/b4b7ab0c59cd416bb5911aec0550d29f
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