Control of membrane barrier during bacterial type-III protein secretion

Type-III secretion systems (T3SSs) are capable of translocating proteins with high speed while maintaining the membrane barrier for small molecules. Here, a structure-function analysis of the T3SS pore complex elucidates the precise mechanisms enabling the gating and the conformational changes requi...

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Autores principales:	Svenja Hüsing, Manuel Halte, Ulf van Look, Alina Guse, Eric J. C. Gálvez, Emmanuelle Charpentier, David F. Blair, Marc Erhardt, Thibaud T. Renault
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/b4b81677e4d248c0b18979bbe7b55964
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spelling	oai:doaj.org-article:b4b81677e4d248c0b18979bbe7b559642021-12-02T18:18:46ZControl of membrane barrier during bacterial type-III protein secretion10.1038/s41467-021-24226-12041-1723https://doaj.org/article/b4b81677e4d248c0b18979bbe7b559642021-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-24226-1https://doaj.org/toc/2041-1723Type-III secretion systems (T3SSs) are capable of translocating proteins with high speed while maintaining the membrane barrier for small molecules. Here, a structure-function analysis of the T3SS pore complex elucidates the precise mechanisms enabling the gating and the conformational changes required for protein substrate secretion.Svenja HüsingManuel HalteUlf van LookAlina GuseEric J. C. GálvezEmmanuelle CharpentierDavid F. BlairMarc ErhardtThibaud T. RenaultNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Svenja Hüsing Manuel Halte Ulf van Look Alina Guse Eric J. C. Gálvez Emmanuelle Charpentier David F. Blair Marc Erhardt Thibaud T. Renault Control of membrane barrier during bacterial type-III protein secretion
description	Type-III secretion systems (T3SSs) are capable of translocating proteins with high speed while maintaining the membrane barrier for small molecules. Here, a structure-function analysis of the T3SS pore complex elucidates the precise mechanisms enabling the gating and the conformational changes required for protein substrate secretion.
format	article
author	Svenja Hüsing Manuel Halte Ulf van Look Alina Guse Eric J. C. Gálvez Emmanuelle Charpentier David F. Blair Marc Erhardt Thibaud T. Renault
author_facet	Svenja Hüsing Manuel Halte Ulf van Look Alina Guse Eric J. C. Gálvez Emmanuelle Charpentier David F. Blair Marc Erhardt Thibaud T. Renault
author_sort	Svenja Hüsing
title	Control of membrane barrier during bacterial type-III protein secretion
title_short	Control of membrane barrier during bacterial type-III protein secretion
title_full	Control of membrane barrier during bacterial type-III protein secretion
title_fullStr	Control of membrane barrier during bacterial type-III protein secretion
title_full_unstemmed	Control of membrane barrier during bacterial type-III protein secretion
title_sort	control of membrane barrier during bacterial type-iii protein secretion
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/b4b81677e4d248c0b18979bbe7b55964
work_keys_str_mv	AT svenjahusing controlofmembranebarrierduringbacterialtypeiiiproteinsecretion AT manuelhalte controlofmembranebarrierduringbacterialtypeiiiproteinsecretion AT ulfvanlook controlofmembranebarrierduringbacterialtypeiiiproteinsecretion AT alinaguse controlofmembranebarrierduringbacterialtypeiiiproteinsecretion AT ericjcgalvez controlofmembranebarrierduringbacterialtypeiiiproteinsecretion AT emmanuellecharpentier controlofmembranebarrierduringbacterialtypeiiiproteinsecretion AT davidfblair controlofmembranebarrierduringbacterialtypeiiiproteinsecretion AT marcerhardt controlofmembranebarrierduringbacterialtypeiiiproteinsecretion AT thibaudtrenault controlofmembranebarrierduringbacterialtypeiiiproteinsecretion
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Control of membrane barrier during bacterial type-III protein secretion

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