Association between exposure to air pollution and late-life neurodegenerative disorders: An umbrella review

Summary: There is growing concern regarding air pollution as a modifiable risk factor for cognitive impairment, dementia, Alzheimer’s disease, and Parkinson’s disease. We conducted an umbrella review to collate the available evidence from systematic reviews and meta-analyses investigating the associ...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	LeeAnn Tan, Erika Nakanishi, Mihye Lee
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2022
Materias:	Air pollution Cognitive impairment Environmental sciences GE1-350
Acceso en línea:	https://doaj.org/article/b4b8751bcfac4f509f06dd37f8d89c0a
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:b4b8751bcfac4f509f06dd37f8d89c0a
record_format	dspace
spelling	oai:doaj.org-article:b4b8751bcfac4f509f06dd37f8d89c0a2021-11-18T04:43:19ZAssociation between exposure to air pollution and late-life neurodegenerative disorders: An umbrella review0160-412010.1016/j.envint.2021.106956https://doaj.org/article/b4b8751bcfac4f509f06dd37f8d89c0a2022-01-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S016041202100581Xhttps://doaj.org/toc/0160-4120Summary: There is growing concern regarding air pollution as a modifiable risk factor for cognitive impairment, dementia, Alzheimer’s disease, and Parkinson’s disease. We conducted an umbrella review to collate the available evidence from systematic reviews and meta-analyses investigating the association between exposure to air pollution and risk of late-life neurodegenerative disorders. A narrative overview and visual summary of the findings from both quantitative and qualitative reviews are presented. A range of air pollutants were assessed in the included meta-analyses; however, only exposure to fine particulate matter (PM2·5) was significantly associated with increased risk of cognitive impairment and Alzheimer’s disease. Although associations between exposure to air pollution and late-life neurodegenerative disorders are frequently reported at the individual study level, as seen in the qualitative summary of findings, attempts to quantitatively synthesise these findings generally resulted in suggestive support for the strength of the associations. Over- or underestimation of effect size is possible in view of the wide variation in methodologies used across individual studies. Recommendations for improvements in design, analysis, and reporting as summarised in the present review should be considered when planning future studies to increase the consistency, comparability, and utility of their findings.LeeAnn TanErika NakanishiMihye LeeElsevierarticleAir pollutionCognitive impairmentEnvironmental sciencesGE1-350ENEnvironment International, Vol 158, Iss , Pp 106956- (2022)
institution	DOAJ
collection	DOAJ
language	EN
topic	Air pollution Cognitive impairment Environmental sciences GE1-350
spellingShingle	Air pollution Cognitive impairment Environmental sciences GE1-350 LeeAnn Tan Erika Nakanishi Mihye Lee Association between exposure to air pollution and late-life neurodegenerative disorders: An umbrella review
description	Summary: There is growing concern regarding air pollution as a modifiable risk factor for cognitive impairment, dementia, Alzheimer’s disease, and Parkinson’s disease. We conducted an umbrella review to collate the available evidence from systematic reviews and meta-analyses investigating the association between exposure to air pollution and risk of late-life neurodegenerative disorders. A narrative overview and visual summary of the findings from both quantitative and qualitative reviews are presented. A range of air pollutants were assessed in the included meta-analyses; however, only exposure to fine particulate matter (PM2·5) was significantly associated with increased risk of cognitive impairment and Alzheimer’s disease. Although associations between exposure to air pollution and late-life neurodegenerative disorders are frequently reported at the individual study level, as seen in the qualitative summary of findings, attempts to quantitatively synthesise these findings generally resulted in suggestive support for the strength of the associations. Over- or underestimation of effect size is possible in view of the wide variation in methodologies used across individual studies. Recommendations for improvements in design, analysis, and reporting as summarised in the present review should be considered when planning future studies to increase the consistency, comparability, and utility of their findings.
format	article
author	LeeAnn Tan Erika Nakanishi Mihye Lee
author_facet	LeeAnn Tan Erika Nakanishi Mihye Lee
author_sort	LeeAnn Tan
title	Association between exposure to air pollution and late-life neurodegenerative disorders: An umbrella review
title_short	Association between exposure to air pollution and late-life neurodegenerative disorders: An umbrella review
title_full	Association between exposure to air pollution and late-life neurodegenerative disorders: An umbrella review
title_fullStr	Association between exposure to air pollution and late-life neurodegenerative disorders: An umbrella review
title_full_unstemmed	Association between exposure to air pollution and late-life neurodegenerative disorders: An umbrella review
title_sort	association between exposure to air pollution and late-life neurodegenerative disorders: an umbrella review
publisher	Elsevier
publishDate	2022
url	https://doaj.org/article/b4b8751bcfac4f509f06dd37f8d89c0a
work_keys_str_mv	AT leeanntan associationbetweenexposuretoairpollutionandlatelifeneurodegenerativedisordersanumbrellareview AT erikanakanishi associationbetweenexposuretoairpollutionandlatelifeneurodegenerativedisordersanumbrellareview AT mihyelee associationbetweenexposuretoairpollutionandlatelifeneurodegenerativedisordersanumbrellareview
_version_	1718425122236268544

Association between exposure to air pollution and late-life neurodegenerative disorders: An umbrella review

Ejemplares similares