Understanding the Role of Fibroblasts following a 3D Tumoroid Implantation for Breast Tumor Formation

An understanding of the participation and modulation of fibroblasts during tumor formation and growth is still unclear. Among many speculates, one might be the technical challenge to reveal the versatile function of fibroblasts in tissue complexity, and another is the dynamics in tissue physiology a...

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Main Author:	Girdhari Rijal
Format:	article
Language:	EN
Published:	MDPI AG 2021
Subjects:	fibroblasts cancer-associated fibroblasts tumor growth tumoroids Technology T Biology (General) QH301-705.5
Online Access:	https://doaj.org/article/b4ba95052c0f4cb6b6e6e0bcbcd1b373
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spelling	oai:doaj.org-article:b4ba95052c0f4cb6b6e6e0bcbcd1b3732021-11-25T16:46:27ZUnderstanding the Role of Fibroblasts following a 3D Tumoroid Implantation for Breast Tumor Formation10.3390/bioengineering81101632306-5354https://doaj.org/article/b4ba95052c0f4cb6b6e6e0bcbcd1b3732021-10-01T00:00:00Zhttps://www.mdpi.com/2306-5354/8/11/163https://doaj.org/toc/2306-5354An understanding of the participation and modulation of fibroblasts during tumor formation and growth is still unclear. Among many speculates, one might be the technical challenge to reveal the versatile function of fibroblasts in tissue complexity, and another is the dynamics in tissue physiology and cell activity. The histology of most solid tumors shows a predominant presence of fibroblasts, suggesting that tumor cells recruit fibroblasts for breast tumor growth. In this review paper, therefore, the migration, activation, differentiation, secretion, and signaling systems that are associated with fibroblasts and cancer-associated fibroblasts (CAFs) after implantation of a breast tumoroid, i.e., a lab-generated tumor tissue into an animal, are discussed.Girdhari RijalMDPI AGarticlefibroblastscancer-associated fibroblaststumor growthtumoroidsTechnologyTBiology (General)QH301-705.5ENBioengineering, Vol 8, Iss 163, p 163 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	fibroblasts cancer-associated fibroblasts tumor growth tumoroids Technology T Biology (General) QH301-705.5
spellingShingle	fibroblasts cancer-associated fibroblasts tumor growth tumoroids Technology T Biology (General) QH301-705.5 Girdhari Rijal Understanding the Role of Fibroblasts following a 3D Tumoroid Implantation for Breast Tumor Formation
description	An understanding of the participation and modulation of fibroblasts during tumor formation and growth is still unclear. Among many speculates, one might be the technical challenge to reveal the versatile function of fibroblasts in tissue complexity, and another is the dynamics in tissue physiology and cell activity. The histology of most solid tumors shows a predominant presence of fibroblasts, suggesting that tumor cells recruit fibroblasts for breast tumor growth. In this review paper, therefore, the migration, activation, differentiation, secretion, and signaling systems that are associated with fibroblasts and cancer-associated fibroblasts (CAFs) after implantation of a breast tumoroid, i.e., a lab-generated tumor tissue into an animal, are discussed.
format	article
author	Girdhari Rijal
author_facet	Girdhari Rijal
author_sort	Girdhari Rijal
title	Understanding the Role of Fibroblasts following a 3D Tumoroid Implantation for Breast Tumor Formation
title_short	Understanding the Role of Fibroblasts following a 3D Tumoroid Implantation for Breast Tumor Formation
title_full	Understanding the Role of Fibroblasts following a 3D Tumoroid Implantation for Breast Tumor Formation
title_fullStr	Understanding the Role of Fibroblasts following a 3D Tumoroid Implantation for Breast Tumor Formation
title_full_unstemmed	Understanding the Role of Fibroblasts following a 3D Tumoroid Implantation for Breast Tumor Formation
title_sort	understanding the role of fibroblasts following a 3d tumoroid implantation for breast tumor formation
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/b4ba95052c0f4cb6b6e6e0bcbcd1b373
work_keys_str_mv	AT girdharirijal understandingtheroleoffibroblastsfollowinga3dtumoroidimplantationforbreasttumorformation
_version_	1718412977351163904

Understanding the Role of Fibroblasts following a 3D Tumoroid Implantation for Breast Tumor Formation

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