Mammalian-Transmissible H5N1 Influenza: Facts and Perspective

ABSTRACT Two recently submitted (but as yet unpublished) studies describe success in creating mutant isolates of H5N1 influenza A virus that can be transmitted via the respiratory route between ferrets; concern has been raised regarding human-to-human transmissibility of these or similar laboratory-...

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Autores principales:	Michael T. Osterholm, Nicholas S. Kelley
Formato:	article
Lenguaje:	EN
Publicado:	American Society for Microbiology 2012
Materias:	Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/b4bf2dd4182f480d8c19c33dfab23779
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spelling	oai:doaj.org-article:b4bf2dd4182f480d8c19c33dfab237792021-11-15T15:39:09ZMammalian-Transmissible H5N1 Influenza: Facts and Perspective10.1128/mBio.00045-122150-7511https://doaj.org/article/b4bf2dd4182f480d8c19c33dfab237792012-05-01T00:00:00Zhttps://journals.asm.org/doi/10.1128/mBio.00045-12https://doaj.org/toc/2150-7511ABSTRACT Two recently submitted (but as yet unpublished) studies describe success in creating mutant isolates of H5N1 influenza A virus that can be transmitted via the respiratory route between ferrets; concern has been raised regarding human-to-human transmissibility of these or similar laboratory-generated influenza viruses. Furthermore, the potential release of methods used in these studies has engendered a great deal of controversy around publishing potential dual-use data and also has served as a catalyst for debates around the true case-fatality rate of H5N1 influenza and the capability of influenza vaccines and antivirals to impact any future unintentional or intentional release of H5N1 virus. In this report, we review available seroepidemiology data for H5N1 infection and discuss how case-finding strategies may influence the overall case-fatality rate reported by the WHO. We also provide information supporting the position that if an H5N1 influenza pandemic occurred, available medical countermeasures would have limited impact on the associated morbidity and mortality.Michael T. OsterholmNicholas S. KelleyAmerican Society for MicrobiologyarticleMicrobiologyQR1-502ENmBio, Vol 3, Iss 2 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Microbiology QR1-502
spellingShingle	Microbiology QR1-502 Michael T. Osterholm Nicholas S. Kelley Mammalian-Transmissible H5N1 Influenza: Facts and Perspective
description	ABSTRACT Two recently submitted (but as yet unpublished) studies describe success in creating mutant isolates of H5N1 influenza A virus that can be transmitted via the respiratory route between ferrets; concern has been raised regarding human-to-human transmissibility of these or similar laboratory-generated influenza viruses. Furthermore, the potential release of methods used in these studies has engendered a great deal of controversy around publishing potential dual-use data and also has served as a catalyst for debates around the true case-fatality rate of H5N1 influenza and the capability of influenza vaccines and antivirals to impact any future unintentional or intentional release of H5N1 virus. In this report, we review available seroepidemiology data for H5N1 infection and discuss how case-finding strategies may influence the overall case-fatality rate reported by the WHO. We also provide information supporting the position that if an H5N1 influenza pandemic occurred, available medical countermeasures would have limited impact on the associated morbidity and mortality.
format	article
author	Michael T. Osterholm Nicholas S. Kelley
author_facet	Michael T. Osterholm Nicholas S. Kelley
author_sort	Michael T. Osterholm
title	Mammalian-Transmissible H5N1 Influenza: Facts and Perspective
title_short	Mammalian-Transmissible H5N1 Influenza: Facts and Perspective
title_full	Mammalian-Transmissible H5N1 Influenza: Facts and Perspective
title_fullStr	Mammalian-Transmissible H5N1 Influenza: Facts and Perspective
title_full_unstemmed	Mammalian-Transmissible H5N1 Influenza: Facts and Perspective
title_sort	mammalian-transmissible h5n1 influenza: facts and perspective
publisher	American Society for Microbiology
publishDate	2012
url	https://doaj.org/article/b4bf2dd4182f480d8c19c33dfab23779
work_keys_str_mv	AT michaeltosterholm mammaliantransmissibleh5n1influenzafactsandperspective AT nicholasskelley mammaliantransmissibleh5n1influenzafactsandperspective
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Mammalian-Transmissible H5N1 Influenza: Facts and Perspective

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