Recent Advances in Multicellular Tumor Spheroid Generation for Drug Screening

Multicellular tumor spheroids (MCTs) have been employed in biomedical fields owing to their advantage in designing a three-dimensional (3D) solid tumor model. For controlling multicellular cancer spheroids, mimicking the tumor extracellular matrix (ECM) microenvironment is important to understand ce...

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Autores principales:	Kwang-Ho Lee, Tae-Hyung Kim
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	MCTs ECM drug screening anticancer drug 3D spheroid culture technology culture platform Biotechnology TP248.13-248.65
Acceso en línea:	https://doaj.org/article/b4c02fc543cb48b9940d53c73c20f8e0
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spelling	oai:doaj.org-article:b4c02fc543cb48b9940d53c73c20f8e02021-11-25T16:55:30ZRecent Advances in Multicellular Tumor Spheroid Generation for Drug Screening10.3390/bios111104452079-6374https://doaj.org/article/b4c02fc543cb48b9940d53c73c20f8e02021-11-01T00:00:00Zhttps://www.mdpi.com/2079-6374/11/11/445https://doaj.org/toc/2079-6374Multicellular tumor spheroids (MCTs) have been employed in biomedical fields owing to their advantage in designing a three-dimensional (3D) solid tumor model. For controlling multicellular cancer spheroids, mimicking the tumor extracellular matrix (ECM) microenvironment is important to understand cell–cell and cell–matrix interactions. In drug cytotoxicity assessments, MCTs provide better mimicry of conventional solid tumors that can precisely represent anticancer drug candidates’ effects. To generate incubate multicellular spheroids, researchers have developed several 3D multicellular spheroid culture technologies to establish a research background and a platform using tumor modelingvia advanced materials science, and biosensing techniques for drug-screening. In application, drug screening was performed in both invasive and non-invasive manners, according to their impact on the spheroids. Here, we review the trend of 3D spheroid culture technology and culture platforms, and their combination with various biosensing techniques for drug screening in the biomedical field.Kwang-Ho LeeTae-Hyung KimMDPI AGarticleMCTsECMdrug screeninganticancer drug3D spheroid culture technologyculture platformBiotechnologyTP248.13-248.65ENBiosensors, Vol 11, Iss 445, p 445 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	MCTs ECM drug screening anticancer drug 3D spheroid culture technology culture platform Biotechnology TP248.13-248.65
spellingShingle	MCTs ECM drug screening anticancer drug 3D spheroid culture technology culture platform Biotechnology TP248.13-248.65 Kwang-Ho Lee Tae-Hyung Kim Recent Advances in Multicellular Tumor Spheroid Generation for Drug Screening
description	Multicellular tumor spheroids (MCTs) have been employed in biomedical fields owing to their advantage in designing a three-dimensional (3D) solid tumor model. For controlling multicellular cancer spheroids, mimicking the tumor extracellular matrix (ECM) microenvironment is important to understand cell–cell and cell–matrix interactions. In drug cytotoxicity assessments, MCTs provide better mimicry of conventional solid tumors that can precisely represent anticancer drug candidates’ effects. To generate incubate multicellular spheroids, researchers have developed several 3D multicellular spheroid culture technologies to establish a research background and a platform using tumor modelingvia advanced materials science, and biosensing techniques for drug-screening. In application, drug screening was performed in both invasive and non-invasive manners, according to their impact on the spheroids. Here, we review the trend of 3D spheroid culture technology and culture platforms, and their combination with various biosensing techniques for drug screening in the biomedical field.
format	article
author	Kwang-Ho Lee Tae-Hyung Kim
author_facet	Kwang-Ho Lee Tae-Hyung Kim
author_sort	Kwang-Ho Lee
title	Recent Advances in Multicellular Tumor Spheroid Generation for Drug Screening
title_short	Recent Advances in Multicellular Tumor Spheroid Generation for Drug Screening
title_full	Recent Advances in Multicellular Tumor Spheroid Generation for Drug Screening
title_fullStr	Recent Advances in Multicellular Tumor Spheroid Generation for Drug Screening
title_full_unstemmed	Recent Advances in Multicellular Tumor Spheroid Generation for Drug Screening
title_sort	recent advances in multicellular tumor spheroid generation for drug screening
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/b4c02fc543cb48b9940d53c73c20f8e0
work_keys_str_mv	AT kwangholee recentadvancesinmulticellulartumorspheroidgenerationfordrugscreening AT taehyungkim recentadvancesinmulticellulartumorspheroidgenerationfordrugscreening
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Recent Advances in Multicellular Tumor Spheroid Generation for Drug Screening

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