<italic toggle="yes">Saccharomyces boulardii</italic> Administration Changes Gut Microbiota and Reduces Hepatic Steatosis, Low<bold>-</bold>Grade Inflammation, and Fat Mass in Obese and Type 2 Diabetic <italic toggle="yes">db</italic>/<italic toggle="yes">db</italic> Mice

ABSTRACT Growing evidence shows that gut microbes are key factors involved in the regulation of energy homeostasis, metabolic inflammation, lipid metabolism, and glucose metabolism. Therefore, gut microbiota modulations caused by selectively fermented oligosaccharides or probiotic bacteria constitut...

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Autores principales:	Amandine Everard, Sébastien Matamoros, Lucie Geurts, Nathalie M. Delzenne, Patrice D. Cani
Formato:	article
Lenguaje:	EN
Publicado:	American Society for Microbiology 2014
Materias:	Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/b4cb0d152e4d4de2918acf876c25c117
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spelling	oai:doaj.org-article:b4cb0d152e4d4de2918acf876c25c1172021-11-15T15:47:38Z<italic toggle="yes">Saccharomyces boulardii</italic> Administration Changes Gut Microbiota and Reduces Hepatic Steatosis, Low<bold>-</bold>Grade Inflammation, and Fat Mass in Obese and Type 2 Diabetic <italic toggle="yes">db</italic>/<italic toggle="yes">db</italic> Mice10.1128/mBio.01011-142150-7511https://doaj.org/article/b4cb0d152e4d4de2918acf876c25c1172014-07-01T00:00:00Zhttps://journals.asm.org/doi/10.1128/mBio.01011-14https://doaj.org/toc/2150-7511ABSTRACT Growing evidence shows that gut microbes are key factors involved in the regulation of energy homeostasis, metabolic inflammation, lipid metabolism, and glucose metabolism. Therefore, gut microbiota modulations caused by selectively fermented oligosaccharides or probiotic bacteria constitute an interesting target in the physiopathology of obesity. However, to date, no probiotic yeast has been investigated in this context. Therefore, our study aimed to evaluate the impact of the most-studied probiotic yeast (i.e., Saccharomyces boulardii Biocodex) on obesity and associated metabolic features, such as fat mass development, hepatic steatosis, and low-grade inflammation, in obese mice. S. boulardii was administered daily by oral gavage to leptin-resistant obese and type 2 diabetic mice (db/db) for 4 weeks. We found that S. boulardii-treated mice exhibited reduced body weight, fat mass, hepatic steatosis, and inflammatory tone. Interestingly, these effects of S. boulardii on host metabolism were associated with local effects in the intestine. S. boulardii increased cecum weight and cecum tissue weight but also induced dramatic changes in the gut microbial composition at the phylum, family, and genus levels. These gut microbiota changes in response to S. boulardii may also be correlated with the host metabolism response. In conclusion, this study demonstrates for the first time that S. boulardii may act as a beneficial probiotic treatment in the context of obesity and type 2 diabetes. IMPORTANCE To date, no probiotic yeast have been investigated in the context of obesity and type 2 diabetes. Here we found that type 2 diabetic and obese mice (db/db) treated with Saccharomyces boulardii exhibited reduced body weight, fat mass, hepatic steatosis, and inflammatory tone. These effects on host metabolism were associated with local effects in the intestine. Importantly, by using pyrosequencing, we found that S. boulardii treatment induces changes of the gut microbiota composition at the phylum, family, and genus levels. Moreover, we found that gut microbiota changes in response to S. boulardii were correlated with several host metabolism responses.Amandine EverardSébastien MatamorosLucie GeurtsNathalie M. DelzennePatrice D. CaniAmerican Society for MicrobiologyarticleMicrobiologyQR1-502ENmBio, Vol 5, Iss 3 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Microbiology QR1-502
spellingShingle	Microbiology QR1-502 Amandine Everard Sébastien Matamoros Lucie Geurts Nathalie M. Delzenne Patrice D. Cani <italic toggle="yes">Saccharomyces boulardii</italic> Administration Changes Gut Microbiota and Reduces Hepatic Steatosis, Low<bold>-</bold>Grade Inflammation, and Fat Mass in Obese and Type 2 Diabetic <italic toggle="yes">db</italic>/<italic toggle="yes">db</italic> Mice
description	ABSTRACT Growing evidence shows that gut microbes are key factors involved in the regulation of energy homeostasis, metabolic inflammation, lipid metabolism, and glucose metabolism. Therefore, gut microbiota modulations caused by selectively fermented oligosaccharides or probiotic bacteria constitute an interesting target in the physiopathology of obesity. However, to date, no probiotic yeast has been investigated in this context. Therefore, our study aimed to evaluate the impact of the most-studied probiotic yeast (i.e., Saccharomyces boulardii Biocodex) on obesity and associated metabolic features, such as fat mass development, hepatic steatosis, and low-grade inflammation, in obese mice. S. boulardii was administered daily by oral gavage to leptin-resistant obese and type 2 diabetic mice (db/db) for 4 weeks. We found that S. boulardii-treated mice exhibited reduced body weight, fat mass, hepatic steatosis, and inflammatory tone. Interestingly, these effects of S. boulardii on host metabolism were associated with local effects in the intestine. S. boulardii increased cecum weight and cecum tissue weight but also induced dramatic changes in the gut microbial composition at the phylum, family, and genus levels. These gut microbiota changes in response to S. boulardii may also be correlated with the host metabolism response. In conclusion, this study demonstrates for the first time that S. boulardii may act as a beneficial probiotic treatment in the context of obesity and type 2 diabetes. IMPORTANCE To date, no probiotic yeast have been investigated in the context of obesity and type 2 diabetes. Here we found that type 2 diabetic and obese mice (db/db) treated with Saccharomyces boulardii exhibited reduced body weight, fat mass, hepatic steatosis, and inflammatory tone. These effects on host metabolism were associated with local effects in the intestine. Importantly, by using pyrosequencing, we found that S. boulardii treatment induces changes of the gut microbiota composition at the phylum, family, and genus levels. Moreover, we found that gut microbiota changes in response to S. boulardii were correlated with several host metabolism responses.
format	article
author	Amandine Everard Sébastien Matamoros Lucie Geurts Nathalie M. Delzenne Patrice D. Cani
author_facet	Amandine Everard Sébastien Matamoros Lucie Geurts Nathalie M. Delzenne Patrice D. Cani
author_sort	Amandine Everard
title	<italic toggle="yes">Saccharomyces boulardii</italic> Administration Changes Gut Microbiota and Reduces Hepatic Steatosis, Low<bold>-</bold>Grade Inflammation, and Fat Mass in Obese and Type 2 Diabetic <italic toggle="yes">db</italic>/<italic toggle="yes">db</italic> Mice
title_short	<italic toggle="yes">Saccharomyces boulardii</italic> Administration Changes Gut Microbiota and Reduces Hepatic Steatosis, Low<bold>-</bold>Grade Inflammation, and Fat Mass in Obese and Type 2 Diabetic <italic toggle="yes">db</italic>/<italic toggle="yes">db</italic> Mice
title_full	<italic toggle="yes">Saccharomyces boulardii</italic> Administration Changes Gut Microbiota and Reduces Hepatic Steatosis, Low<bold>-</bold>Grade Inflammation, and Fat Mass in Obese and Type 2 Diabetic <italic toggle="yes">db</italic>/<italic toggle="yes">db</italic> Mice
title_fullStr	<italic toggle="yes">Saccharomyces boulardii</italic> Administration Changes Gut Microbiota and Reduces Hepatic Steatosis, Low<bold>-</bold>Grade Inflammation, and Fat Mass in Obese and Type 2 Diabetic <italic toggle="yes">db</italic>/<italic toggle="yes">db</italic> Mice
title_full_unstemmed	<italic toggle="yes">Saccharomyces boulardii</italic> Administration Changes Gut Microbiota and Reduces Hepatic Steatosis, Low<bold>-</bold>Grade Inflammation, and Fat Mass in Obese and Type 2 Diabetic <italic toggle="yes">db</italic>/<italic toggle="yes">db</italic> Mice
title_sort	<italic toggle="yes">saccharomyces boulardii</italic> administration changes gut microbiota and reduces hepatic steatosis, low<bold>-</bold>grade inflammation, and fat mass in obese and type 2 diabetic <italic toggle="yes">db</italic>/<italic toggle="yes">db</italic> mice
publisher	American Society for Microbiology
publishDate	2014
url	https://doaj.org/article/b4cb0d152e4d4de2918acf876c25c117
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<italic toggle="yes">Saccharomyces boulardii</italic> Administration Changes Gut Microbiota and Reduces Hepatic Steatosis, Low<bold>-</bold>Grade Inflammation, and Fat Mass in Obese and Type 2 Diabetic <italic toggle="yes">db</italic>/<italic toggle="yes">db</italic> Mice

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