Sulfonylurea Receptor 1 in Central Nervous System Injury: An Updated Review
Sulfonylurea receptor 1 (SUR1) is a member of the adenosine triphosphate (ATP)-binding cassette (ABC) protein superfamily, encoded by Abcc8, and is recognized as a key mediator of central nervous system (CNS) cellular swelling via the transient receptor potential melastatin 4 (TRPM4) channel. Discov...
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MDPI AG
2021
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oai:doaj.org-article:b4cbc90795874d4aba03952cb01d898c2021-11-11T17:18:56ZSulfonylurea Receptor 1 in Central Nervous System Injury: An Updated Review10.3390/ijms2221118991422-00671661-6596https://doaj.org/article/b4cbc90795874d4aba03952cb01d898c2021-11-01T00:00:00Zhttps://www.mdpi.com/1422-0067/22/21/11899https://doaj.org/toc/1661-6596https://doaj.org/toc/1422-0067Sulfonylurea receptor 1 (SUR1) is a member of the adenosine triphosphate (ATP)-binding cassette (ABC) protein superfamily, encoded by Abcc8, and is recognized as a key mediator of central nervous system (CNS) cellular swelling via the transient receptor potential melastatin 4 (TRPM4) channel. Discovered approximately 20 years ago, this channel is normally absent in the CNS but is transcriptionally upregulated after CNS injury. A comprehensive review on the pathophysiology and role of SUR1 in the CNS was published in 2012. Since then, the breadth and depth of understanding of the involvement of this channel in secondary injury has undergone exponential growth: SUR1-TRPM4 inhibition has been shown to decrease cerebral edema and hemorrhage progression in multiple preclinical models as well as in early clinical studies across a range of CNS diseases including ischemic stroke, traumatic brain injury, cardiac arrest, subarachnoid hemorrhage, spinal cord injury, intracerebral hemorrhage, multiple sclerosis, encephalitis, neuromalignancies, pain, liver failure, status epilepticus, retinopathies and HIV-associated neurocognitive disorder. Given these substantial developments, combined with the timeliness of ongoing clinical trials of SUR1 inhibition, now, another decade later, we review advances pertaining to SUR1-TRPM4 pathobiology in this spectrum of CNS disease—providing an overview of the journey from patch-clamp experiments to phase III trials.Ruchira M. JhaAnupama RaniShashvat M. DesaiSudhanshu RaikwarSandra MihaljevicAmanda Munoz-CasabellaPatrick M. KochanekJoshua CatapanoEthan WinklerGiuseppe CiterioJ. Claude HemphillW. Taylor KimberlyRaj NarayanJuan SahuquilloKevin N. ShethJ. Marc SimardMDPI AGarticlesulfonylurea receptoredemacellular swellingtraumatic brain injurystrokeSUR 1Biology (General)QH301-705.5ChemistryQD1-999ENInternational Journal of Molecular Sciences, Vol 22, Iss 11899, p 11899 (2021) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
sulfonylurea receptor edema cellular swelling traumatic brain injury stroke SUR 1 Biology (General) QH301-705.5 Chemistry QD1-999 |
| spellingShingle |
sulfonylurea receptor edema cellular swelling traumatic brain injury stroke SUR 1 Biology (General) QH301-705.5 Chemistry QD1-999 Ruchira M. Jha Anupama Rani Shashvat M. Desai Sudhanshu Raikwar Sandra Mihaljevic Amanda Munoz-Casabella Patrick M. Kochanek Joshua Catapano Ethan Winkler Giuseppe Citerio J. Claude Hemphill W. Taylor Kimberly Raj Narayan Juan Sahuquillo Kevin N. Sheth J. Marc Simard Sulfonylurea Receptor 1 in Central Nervous System Injury: An Updated Review |
| description |
Sulfonylurea receptor 1 (SUR1) is a member of the adenosine triphosphate (ATP)-binding cassette (ABC) protein superfamily, encoded by Abcc8, and is recognized as a key mediator of central nervous system (CNS) cellular swelling via the transient receptor potential melastatin 4 (TRPM4) channel. Discovered approximately 20 years ago, this channel is normally absent in the CNS but is transcriptionally upregulated after CNS injury. A comprehensive review on the pathophysiology and role of SUR1 in the CNS was published in 2012. Since then, the breadth and depth of understanding of the involvement of this channel in secondary injury has undergone exponential growth: SUR1-TRPM4 inhibition has been shown to decrease cerebral edema and hemorrhage progression in multiple preclinical models as well as in early clinical studies across a range of CNS diseases including ischemic stroke, traumatic brain injury, cardiac arrest, subarachnoid hemorrhage, spinal cord injury, intracerebral hemorrhage, multiple sclerosis, encephalitis, neuromalignancies, pain, liver failure, status epilepticus, retinopathies and HIV-associated neurocognitive disorder. Given these substantial developments, combined with the timeliness of ongoing clinical trials of SUR1 inhibition, now, another decade later, we review advances pertaining to SUR1-TRPM4 pathobiology in this spectrum of CNS disease—providing an overview of the journey from patch-clamp experiments to phase III trials. |
| format |
article |
| author |
Ruchira M. Jha Anupama Rani Shashvat M. Desai Sudhanshu Raikwar Sandra Mihaljevic Amanda Munoz-Casabella Patrick M. Kochanek Joshua Catapano Ethan Winkler Giuseppe Citerio J. Claude Hemphill W. Taylor Kimberly Raj Narayan Juan Sahuquillo Kevin N. Sheth J. Marc Simard |
| author_facet |
Ruchira M. Jha Anupama Rani Shashvat M. Desai Sudhanshu Raikwar Sandra Mihaljevic Amanda Munoz-Casabella Patrick M. Kochanek Joshua Catapano Ethan Winkler Giuseppe Citerio J. Claude Hemphill W. Taylor Kimberly Raj Narayan Juan Sahuquillo Kevin N. Sheth J. Marc Simard |
| author_sort |
Ruchira M. Jha |
| title |
Sulfonylurea Receptor 1 in Central Nervous System Injury: An Updated Review |
| title_short |
Sulfonylurea Receptor 1 in Central Nervous System Injury: An Updated Review |
| title_full |
Sulfonylurea Receptor 1 in Central Nervous System Injury: An Updated Review |
| title_fullStr |
Sulfonylurea Receptor 1 in Central Nervous System Injury: An Updated Review |
| title_full_unstemmed |
Sulfonylurea Receptor 1 in Central Nervous System Injury: An Updated Review |
| title_sort |
sulfonylurea receptor 1 in central nervous system injury: an updated review |
| publisher |
MDPI AG |
| publishDate |
2021 |
| url |
https://doaj.org/article/b4cbc90795874d4aba03952cb01d898c |
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