Repair of DNA strand breaks in a minichromosome in vivo: kinetics, modeling, and effects of inhibitors.

To obtain an overall picture of the repair of DNA single and double strand breaks in a defined region of chromatin in vivo, we studied their repair in a ~170 kb circular minichromosome whose length and topology are analogous to those of the closed loops in genomic chromatin. The rate of repair of si...

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Bibliographic Details
Main Authors: Slawomir Kumala, Krzysztof Fujarewicz, Dheekollu Jayaraju, Joanna Rzeszowska-Wolny, Ronald Hancock
Format: article
Language:EN
Published: Public Library of Science (PLoS) 2013
Subjects:
R
Q
Online Access:https://doaj.org/article/b4ce648ea9c1414f86efa97f7ed2c567
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