Gene Expression Changes with Minor Effects on the Population Average Have Major Effects on the Occurrence of Cells with Extreme Protein Concentrations

ABSTRACT The cell-to-cell heterogeneity in a bacterial population provides a rich response to environmental changes and robust survival of an isogenic population. Especially, the rare, extreme phenotypes can be important for survival under transient lethal conditions. We analyze the probability of h...

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Autores principales:	Mikkel Skjoldan Svenningsen, Szabolcs Semsey, Namiko Mitarai
Formato:	article
Lenguaje:	EN
Publicado:	American Society for Microbiology 2019
Materias:	distribution noise rare events Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/b4cfb303a7374519ae11fcf279ef268d
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spelling	oai:doaj.org-article:b4cfb303a7374519ae11fcf279ef268d2021-11-15T15:22:04ZGene Expression Changes with Minor Effects on the Population Average Have Major Effects on the Occurrence of Cells with Extreme Protein Concentrations10.1128/mSphere.00575-182379-5042https://doaj.org/article/b4cfb303a7374519ae11fcf279ef268d2019-02-01T00:00:00Zhttps://journals.asm.org/doi/10.1128/mSphere.00575-18https://doaj.org/toc/2379-5042ABSTRACT The cell-to-cell heterogeneity in a bacterial population provides a rich response to environmental changes and robust survival of an isogenic population. Especially, the rare, extreme phenotypes can be important for survival under transient lethal conditions. We analyze the probability of having an extremely high or low protein level in a stochastic model of gene expression. The fraction of rare state cells defined as the cells in the tails of distributions is found to be highly sensitive to small changes of the mean protein level. The result highlights the importance of relatively weak changes to the mean for the occurrence of rare phenotypes.Mikkel Skjoldan SvenningsenSzabolcs SemseyNamiko MitaraiAmerican Society for Microbiologyarticledistributionnoiserare eventsMicrobiologyQR1-502ENmSphere, Vol 4, Iss 1 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	distribution noise rare events Microbiology QR1-502
spellingShingle	distribution noise rare events Microbiology QR1-502 Mikkel Skjoldan Svenningsen Szabolcs Semsey Namiko Mitarai Gene Expression Changes with Minor Effects on the Population Average Have Major Effects on the Occurrence of Cells with Extreme Protein Concentrations
description	ABSTRACT The cell-to-cell heterogeneity in a bacterial population provides a rich response to environmental changes and robust survival of an isogenic population. Especially, the rare, extreme phenotypes can be important for survival under transient lethal conditions. We analyze the probability of having an extremely high or low protein level in a stochastic model of gene expression. The fraction of rare state cells defined as the cells in the tails of distributions is found to be highly sensitive to small changes of the mean protein level. The result highlights the importance of relatively weak changes to the mean for the occurrence of rare phenotypes.
format	article
author	Mikkel Skjoldan Svenningsen Szabolcs Semsey Namiko Mitarai
author_facet	Mikkel Skjoldan Svenningsen Szabolcs Semsey Namiko Mitarai
author_sort	Mikkel Skjoldan Svenningsen
title	Gene Expression Changes with Minor Effects on the Population Average Have Major Effects on the Occurrence of Cells with Extreme Protein Concentrations
title_short	Gene Expression Changes with Minor Effects on the Population Average Have Major Effects on the Occurrence of Cells with Extreme Protein Concentrations
title_full	Gene Expression Changes with Minor Effects on the Population Average Have Major Effects on the Occurrence of Cells with Extreme Protein Concentrations
title_fullStr	Gene Expression Changes with Minor Effects on the Population Average Have Major Effects on the Occurrence of Cells with Extreme Protein Concentrations
title_full_unstemmed	Gene Expression Changes with Minor Effects on the Population Average Have Major Effects on the Occurrence of Cells with Extreme Protein Concentrations
title_sort	gene expression changes with minor effects on the population average have major effects on the occurrence of cells with extreme protein concentrations
publisher	American Society for Microbiology
publishDate	2019
url	https://doaj.org/article/b4cfb303a7374519ae11fcf279ef268d
work_keys_str_mv	AT mikkelskjoldansvenningsen geneexpressionchangeswithminoreffectsonthepopulationaveragehavemajoreffectsontheoccurrenceofcellswithextremeproteinconcentrations AT szabolcssemsey geneexpressionchangeswithminoreffectsonthepopulationaveragehavemajoreffectsontheoccurrenceofcellswithextremeproteinconcentrations AT namikomitarai geneexpressionchangeswithminoreffectsonthepopulationaveragehavemajoreffectsontheoccurrenceofcellswithextremeproteinconcentrations
_version_	1718428092618244096

Gene Expression Changes with Minor Effects on the Population Average Have Major Effects on the Occurrence of Cells with Extreme Protein Concentrations

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