Rhomboid family member 2 regulates cytoskeletal stress-associated Keratin 16

Keratin 16 is an epithelial protein highly expressed at pressure bearing sites and during wound healing and cancer. Here the authors show that K16 interacts with the inactive protease Rhbdf2, associated with Tylosis with oesophageal cancer, and that this interaction drives increased keratinocyte pro...

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Autores principales:	Thiviyani Maruthappu, Anissa Chikh, Benjamin Fell, Paul J. Delaney, Matthew A. Brooke, Clemence Levet, Angela Moncada-Pazos, Akemi Ishida-Yamamoto, Diana Blaydon, Ahmad Waseem, Irene M. Leigh, Matthew Freeman, David P. Kelsell
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/b4cfedfe8b0b4b1e98605a9262df868a
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spelling	oai:doaj.org-article:b4cfedfe8b0b4b1e98605a9262df868a2021-12-02T17:06:28ZRhomboid family member 2 regulates cytoskeletal stress-associated Keratin 1610.1038/ncomms141742041-1723https://doaj.org/article/b4cfedfe8b0b4b1e98605a9262df868a2017-01-01T00:00:00Zhttps://doi.org/10.1038/ncomms14174https://doaj.org/toc/2041-1723Keratin 16 is an epithelial protein highly expressed at pressure bearing sites and during wound healing and cancer. Here the authors show that K16 interacts with the inactive protease Rhbdf2, associated with Tylosis with oesophageal cancer, and that this interaction drives increased keratinocyte proliferation.Thiviyani MaruthappuAnissa ChikhBenjamin FellPaul J. DelaneyMatthew A. BrookeClemence LevetAngela Moncada-PazosAkemi Ishida-YamamotoDiana BlaydonAhmad WaseemIrene M. LeighMatthew FreemanDavid P. KelsellNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-11 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Thiviyani Maruthappu Anissa Chikh Benjamin Fell Paul J. Delaney Matthew A. Brooke Clemence Levet Angela Moncada-Pazos Akemi Ishida-Yamamoto Diana Blaydon Ahmad Waseem Irene M. Leigh Matthew Freeman David P. Kelsell Rhomboid family member 2 regulates cytoskeletal stress-associated Keratin 16
description	Keratin 16 is an epithelial protein highly expressed at pressure bearing sites and during wound healing and cancer. Here the authors show that K16 interacts with the inactive protease Rhbdf2, associated with Tylosis with oesophageal cancer, and that this interaction drives increased keratinocyte proliferation.
format	article
author	Thiviyani Maruthappu Anissa Chikh Benjamin Fell Paul J. Delaney Matthew A. Brooke Clemence Levet Angela Moncada-Pazos Akemi Ishida-Yamamoto Diana Blaydon Ahmad Waseem Irene M. Leigh Matthew Freeman David P. Kelsell
author_facet	Thiviyani Maruthappu Anissa Chikh Benjamin Fell Paul J. Delaney Matthew A. Brooke Clemence Levet Angela Moncada-Pazos Akemi Ishida-Yamamoto Diana Blaydon Ahmad Waseem Irene M. Leigh Matthew Freeman David P. Kelsell
author_sort	Thiviyani Maruthappu
title	Rhomboid family member 2 regulates cytoskeletal stress-associated Keratin 16
title_short	Rhomboid family member 2 regulates cytoskeletal stress-associated Keratin 16
title_full	Rhomboid family member 2 regulates cytoskeletal stress-associated Keratin 16
title_fullStr	Rhomboid family member 2 regulates cytoskeletal stress-associated Keratin 16
title_full_unstemmed	Rhomboid family member 2 regulates cytoskeletal stress-associated Keratin 16
title_sort	rhomboid family member 2 regulates cytoskeletal stress-associated keratin 16
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/b4cfedfe8b0b4b1e98605a9262df868a
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Rhomboid family member 2 regulates cytoskeletal stress-associated Keratin 16

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