Epidemiologic evidence linking oxidative stress and pulmonary function in healthy populations

Respiratory health in the general population declines regardless of the presence of pulmonary diseases. Oxidative stress has been implicated as one of the mechanisms involved in respiratory dysfunction. This review was to evaluate studies that relate oxidative stress factors with pulmonary function...

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Autores principales:	Lateef Olabisi Okeleji, Ayodeji Folorunsho Ajayi, Grace Adebayo-Gege, Victoria Oyetayo Aremu, Oluwadunsin Iyanuoluwa Adebayo, Emmanuel Tayo Adebayo
Formato:	article
Lenguaje:	EN
Publicado:	KeAi Communications Co., Ltd. 2021
Materias:	Pulmonary diseases Oxidative stress Respiratory function test Epidemiology Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/b4d0c464910649bf88eea5e16523605d
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spelling	oai:doaj.org-article:b4d0c464910649bf88eea5e16523605d2021-12-02T16:01:35ZEpidemiologic evidence linking oxidative stress and pulmonary function in healthy populations2095-882X10.1016/j.cdtm.2020.11.004https://doaj.org/article/b4d0c464910649bf88eea5e16523605d2021-06-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2095882X20300967https://doaj.org/toc/2095-882XRespiratory health in the general population declines regardless of the presence of pulmonary diseases. Oxidative stress has been implicated as one of the mechanisms involved in respiratory dysfunction. This review was to evaluate studies that relate oxidative stress factors with pulmonary function among the general population without prior respiratory illnesses. The search yielded 54 citations. Twenty-one studies qualified for incorporation in this review. Owing to the heterogeneity of the review, studies were discussed based on identified oxidative stress factors responsible for pulmonary dysfunction. Oxidative stress biomarkers, including gene polymorphisms of nuclear factor erythroid 2-related factor 2, heme oxygenase 1, glutathione S transferase, superoxide dismutase, and lipid peroxidation products were involved in lung function decline. In addition, the antioxidant status of individuals in reference to dietary antioxidant intake and exposure to environmental pollutants affected oxidative stress and pulmonary function, as indicated by forced expired volume in one second, forced vital capacity, and forced expiratory flow at 25%–75%. This review indicated that oxidative stress is implicated in the gradual decline of lung function among the general population, and gene polymorphism along the antioxidant defense line and/or their interaction with air pollutants reduce lung function. Different polymorphic forms among individuals explain why the rate of lung function decline differs among people. Dietary antioxidants have respiratory health benefits in antioxidant gene polymorphic forms. Therefore, the genetic composition of an individual may be considered for monitoring and identifying people at risk of respiratory illnesses.Lateef Olabisi OkelejiAyodeji Folorunsho AjayiGrace Adebayo-GegeVictoria Oyetayo AremuOluwadunsin Iyanuoluwa AdebayoEmmanuel Tayo AdebayoKeAi Communications Co., Ltd.articlePulmonary diseasesOxidative stressRespiratory function testEpidemiologyMedicine (General)R5-920ENChronic Diseases and Translational Medicine, Vol 7, Iss 2, Pp 88-99 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Pulmonary diseases Oxidative stress Respiratory function test Epidemiology Medicine (General) R5-920
spellingShingle	Pulmonary diseases Oxidative stress Respiratory function test Epidemiology Medicine (General) R5-920 Lateef Olabisi Okeleji Ayodeji Folorunsho Ajayi Grace Adebayo-Gege Victoria Oyetayo Aremu Oluwadunsin Iyanuoluwa Adebayo Emmanuel Tayo Adebayo Epidemiologic evidence linking oxidative stress and pulmonary function in healthy populations
description	Respiratory health in the general population declines regardless of the presence of pulmonary diseases. Oxidative stress has been implicated as one of the mechanisms involved in respiratory dysfunction. This review was to evaluate studies that relate oxidative stress factors with pulmonary function among the general population without prior respiratory illnesses. The search yielded 54 citations. Twenty-one studies qualified for incorporation in this review. Owing to the heterogeneity of the review, studies were discussed based on identified oxidative stress factors responsible for pulmonary dysfunction. Oxidative stress biomarkers, including gene polymorphisms of nuclear factor erythroid 2-related factor 2, heme oxygenase 1, glutathione S transferase, superoxide dismutase, and lipid peroxidation products were involved in lung function decline. In addition, the antioxidant status of individuals in reference to dietary antioxidant intake and exposure to environmental pollutants affected oxidative stress and pulmonary function, as indicated by forced expired volume in one second, forced vital capacity, and forced expiratory flow at 25%–75%. This review indicated that oxidative stress is implicated in the gradual decline of lung function among the general population, and gene polymorphism along the antioxidant defense line and/or their interaction with air pollutants reduce lung function. Different polymorphic forms among individuals explain why the rate of lung function decline differs among people. Dietary antioxidants have respiratory health benefits in antioxidant gene polymorphic forms. Therefore, the genetic composition of an individual may be considered for monitoring and identifying people at risk of respiratory illnesses.
format	article
author	Lateef Olabisi Okeleji Ayodeji Folorunsho Ajayi Grace Adebayo-Gege Victoria Oyetayo Aremu Oluwadunsin Iyanuoluwa Adebayo Emmanuel Tayo Adebayo
author_facet	Lateef Olabisi Okeleji Ayodeji Folorunsho Ajayi Grace Adebayo-Gege Victoria Oyetayo Aremu Oluwadunsin Iyanuoluwa Adebayo Emmanuel Tayo Adebayo
author_sort	Lateef Olabisi Okeleji
title	Epidemiologic evidence linking oxidative stress and pulmonary function in healthy populations
title_short	Epidemiologic evidence linking oxidative stress and pulmonary function in healthy populations
title_full	Epidemiologic evidence linking oxidative stress and pulmonary function in healthy populations
title_fullStr	Epidemiologic evidence linking oxidative stress and pulmonary function in healthy populations
title_full_unstemmed	Epidemiologic evidence linking oxidative stress and pulmonary function in healthy populations
title_sort	epidemiologic evidence linking oxidative stress and pulmonary function in healthy populations
publisher	KeAi Communications Co., Ltd.
publishDate	2021
url	https://doaj.org/article/b4d0c464910649bf88eea5e16523605d
work_keys_str_mv	AT lateefolabisiokeleji epidemiologicevidencelinkingoxidativestressandpulmonaryfunctioninhealthypopulations AT ayodejifolorunshoajayi epidemiologicevidencelinkingoxidativestressandpulmonaryfunctioninhealthypopulations AT graceadebayogege epidemiologicevidencelinkingoxidativestressandpulmonaryfunctioninhealthypopulations AT victoriaoyetayoaremu epidemiologicevidencelinkingoxidativestressandpulmonaryfunctioninhealthypopulations AT oluwadunsiniyanuoluwaadebayo epidemiologicevidencelinkingoxidativestressandpulmonaryfunctioninhealthypopulations AT emmanueltayoadebayo epidemiologicevidencelinkingoxidativestressandpulmonaryfunctioninhealthypopulations
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Epidemiologic evidence linking oxidative stress and pulmonary function in healthy populations

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