Evaluation of Acanthamoeba keratitis cases in a tertiary medical care centre over 21 years

Abstract To report on Acanthamoeba keratitis cases in a tertiary university eye-hospital in Graz, Austria, over a 21-year period. Retrospective study. Parameters included demographics, diagnostics, clinical courses, medical therapies, surgical interventions, secondary complications, and best spectac...

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Autores principales: Wolfgang List, Wilfried Glatz, Regina Riedl, Georg Mossboeck, Gernot Steinwender, Andreas Wedrich
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Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/b4d4f4323cac4878b4c1098c1863b51a
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spelling oai:doaj.org-article:b4d4f4323cac4878b4c1098c1863b51a2021-12-02T15:22:57ZEvaluation of Acanthamoeba keratitis cases in a tertiary medical care centre over 21 years10.1038/s41598-020-80222-32045-2322https://doaj.org/article/b4d4f4323cac4878b4c1098c1863b51a2021-01-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-80222-3https://doaj.org/toc/2045-2322Abstract To report on Acanthamoeba keratitis cases in a tertiary university eye-hospital in Graz, Austria, over a 21-year period. Retrospective study. Parameters included demographics, diagnostics, clinical courses, medical therapies, surgical interventions, secondary complications, and best spectacle-corrected visual acuity (BSCVA). Patient records for 44 eyes of 42 patients were analysed; 2 bilateral infections. Mean age at presentation was 31 ± 13 (16–65) years; contact lenses were used in 41 of 44 eyes (93.2%). Symptoms at initial presentation were mainly pain (41/43, 95.3%) and photophobia (16/43, 37.2%). Most frequent morphological findings were stromal infiltrates (30/44, 68.2%). Diagnosis was mainly confirmed by smears (40/42, 95.2%) and polymerase chain reaction (8/42, 19%). Antiamoebic treatment comprised biguanides and diamidines. Penetrating keratoplasty was performed in 10/44 (22.7%) eyes. Median time from symptom onset to initial visit was 2 (0–26) weeks; median follow-up was 30 (2–1008) weeks. BSCVA improved in 23/36 (63.9%) eyes, remained unchanged in 6/36 (16.7%) eyes and deteriorated in 7/36 (19.4%) eyes. Acanthamoeba keratitis predominantly occurs in young contact lens wearers. Diagnosis should be considered in patients with pain and stromal infiltrates. In the majority of cases, BSCVA can be improved. Early diagnosis and adequate treatment should be implemented to prevent complications.Wolfgang ListWilfried GlatzRegina RiedlGeorg MossboeckGernot SteinwenderAndreas WedrichNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
institution DOAJ
collection DOAJ
language EN
topic Medicine
R
Science
Q
spellingShingle Medicine
R
Science
Q
Wolfgang List
Wilfried Glatz
Regina Riedl
Georg Mossboeck
Gernot Steinwender
Andreas Wedrich
Evaluation of Acanthamoeba keratitis cases in a tertiary medical care centre over 21 years
description Abstract To report on Acanthamoeba keratitis cases in a tertiary university eye-hospital in Graz, Austria, over a 21-year period. Retrospective study. Parameters included demographics, diagnostics, clinical courses, medical therapies, surgical interventions, secondary complications, and best spectacle-corrected visual acuity (BSCVA). Patient records for 44 eyes of 42 patients were analysed; 2 bilateral infections. Mean age at presentation was 31 ± 13 (16–65) years; contact lenses were used in 41 of 44 eyes (93.2%). Symptoms at initial presentation were mainly pain (41/43, 95.3%) and photophobia (16/43, 37.2%). Most frequent morphological findings were stromal infiltrates (30/44, 68.2%). Diagnosis was mainly confirmed by smears (40/42, 95.2%) and polymerase chain reaction (8/42, 19%). Antiamoebic treatment comprised biguanides and diamidines. Penetrating keratoplasty was performed in 10/44 (22.7%) eyes. Median time from symptom onset to initial visit was 2 (0–26) weeks; median follow-up was 30 (2–1008) weeks. BSCVA improved in 23/36 (63.9%) eyes, remained unchanged in 6/36 (16.7%) eyes and deteriorated in 7/36 (19.4%) eyes. Acanthamoeba keratitis predominantly occurs in young contact lens wearers. Diagnosis should be considered in patients with pain and stromal infiltrates. In the majority of cases, BSCVA can be improved. Early diagnosis and adequate treatment should be implemented to prevent complications.
format article
author Wolfgang List
Wilfried Glatz
Regina Riedl
Georg Mossboeck
Gernot Steinwender
Andreas Wedrich
author_facet Wolfgang List
Wilfried Glatz
Regina Riedl
Georg Mossboeck
Gernot Steinwender
Andreas Wedrich
author_sort Wolfgang List
title Evaluation of Acanthamoeba keratitis cases in a tertiary medical care centre over 21 years
title_short Evaluation of Acanthamoeba keratitis cases in a tertiary medical care centre over 21 years
title_full Evaluation of Acanthamoeba keratitis cases in a tertiary medical care centre over 21 years
title_fullStr Evaluation of Acanthamoeba keratitis cases in a tertiary medical care centre over 21 years
title_full_unstemmed Evaluation of Acanthamoeba keratitis cases in a tertiary medical care centre over 21 years
title_sort evaluation of acanthamoeba keratitis cases in a tertiary medical care centre over 21 years
publisher Nature Portfolio
publishDate 2021
url https://doaj.org/article/b4d4f4323cac4878b4c1098c1863b51a
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