A comprehensive single cell transcriptional landscape of human hematopoietic progenitors

Human Hematopoietic stem and progenitor cells (HSPCs) are commonly defined by CD34 expression. Here, the authors map single-cell RNA states both inside and outside the CD34 compartment, uncovering previously unappreciated branchpoints and validating CD164 as an efficient marker for early HSPCs.

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Autores principales:	Danilo Pellin, Mariana Loperfido, Cristina Baricordi, Samuel L. Wolock, Annita Montepeloso, Olga K. Weinberg, Alessandra Biffi, Allon M. Klein, Luca Biasco
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/b4d60ac10b844ab591805a070600b761
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spelling	oai:doaj.org-article:b4d60ac10b844ab591805a070600b7612021-12-02T17:32:10ZA comprehensive single cell transcriptional landscape of human hematopoietic progenitors10.1038/s41467-019-10291-02041-1723https://doaj.org/article/b4d60ac10b844ab591805a070600b7612019-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-10291-0https://doaj.org/toc/2041-1723Human Hematopoietic stem and progenitor cells (HSPCs) are commonly defined by CD34 expression. Here, the authors map single-cell RNA states both inside and outside the CD34 compartment, uncovering previously unappreciated branchpoints and validating CD164 as an efficient marker for early HSPCs.Danilo PellinMariana LoperfidoCristina BaricordiSamuel L. WolockAnnita MontepelosoOlga K. WeinbergAlessandra BiffiAllon M. KleinLuca BiascoNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Danilo Pellin Mariana Loperfido Cristina Baricordi Samuel L. Wolock Annita Montepeloso Olga K. Weinberg Alessandra Biffi Allon M. Klein Luca Biasco A comprehensive single cell transcriptional landscape of human hematopoietic progenitors
description	Human Hematopoietic stem and progenitor cells (HSPCs) are commonly defined by CD34 expression. Here, the authors map single-cell RNA states both inside and outside the CD34 compartment, uncovering previously unappreciated branchpoints and validating CD164 as an efficient marker for early HSPCs.
format	article
author	Danilo Pellin Mariana Loperfido Cristina Baricordi Samuel L. Wolock Annita Montepeloso Olga K. Weinberg Alessandra Biffi Allon M. Klein Luca Biasco
author_facet	Danilo Pellin Mariana Loperfido Cristina Baricordi Samuel L. Wolock Annita Montepeloso Olga K. Weinberg Alessandra Biffi Allon M. Klein Luca Biasco
author_sort	Danilo Pellin
title	A comprehensive single cell transcriptional landscape of human hematopoietic progenitors
title_short	A comprehensive single cell transcriptional landscape of human hematopoietic progenitors
title_full	A comprehensive single cell transcriptional landscape of human hematopoietic progenitors
title_fullStr	A comprehensive single cell transcriptional landscape of human hematopoietic progenitors
title_full_unstemmed	A comprehensive single cell transcriptional landscape of human hematopoietic progenitors
title_sort	comprehensive single cell transcriptional landscape of human hematopoietic progenitors
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/b4d60ac10b844ab591805a070600b761
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A comprehensive single cell transcriptional landscape of human hematopoietic progenitors

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