High prevalence of symptoms among Brazilian subjects with antibodies against SARS-CoV-2

Abstract Since the beginning of the pandemic of COVID-19, there has been a widespread assumption that most infected persons are asymptomatic. Using data from the recent wave of the EPICOVID19 study, a nationwide household-based survey including 133 cities from all states of Brazil, we estimated the...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Ana M. B. Menezes, Cesar G. Victora, Fernando P. Hartwig, Mariângela F. Silveira, Bernardo L. Horta, Aluísio J. D. Barros, Marilia A. Mesenburg, Fernando C. Wehrmeister, Lúcia C. Pellanda, Odir A. Dellagostin, Cláudio J. Struchiner, Marcelo N. Burattini, Fernando C. Barros, Pedro C. Hallal
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/b4dbffcd6e78489f849ed91d1a9ca705
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:b4dbffcd6e78489f849ed91d1a9ca705
record_format	dspace
spelling	oai:doaj.org-article:b4dbffcd6e78489f849ed91d1a9ca7052021-12-02T17:44:54ZHigh prevalence of symptoms among Brazilian subjects with antibodies against SARS-CoV-210.1038/s41598-021-92775-y2045-2322https://doaj.org/article/b4dbffcd6e78489f849ed91d1a9ca7052021-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-92775-yhttps://doaj.org/toc/2045-2322Abstract Since the beginning of the pandemic of COVID-19, there has been a widespread assumption that most infected persons are asymptomatic. Using data from the recent wave of the EPICOVID19 study, a nationwide household-based survey including 133 cities from all states of Brazil, we estimated the proportion of people with and without antibodies for SARS-CoV-2 who were asymptomatic, which symptoms were most frequently reported, number of symptoms and the association with socio-demographic characteristics. We tested 33,205 subjects using a rapid antibody test previously validated. Information was collected before participants received the test result. Out of 849 (2.7%) participants positive for SARS-CoV-2 antibodies, only 12.1% (95% CI 10.1–14.5) reported no symptoms, compared to 42.2% (95% CI 41.7–42.8) among those negative. The largest difference between the two groups was observed for changes in smell/taste (56.5% versus 9.1%, a 6.2-fold difference). Changes in smell/taste, fever and body aches were most likely to predict positive tests as suggested by recursive partitioning tree analysis. Among individuals without any of these three symptoms, only 0.8% tested positive, compared to 18.3% of those with both fever and changes in smell or taste. Most subjects with antibodies against SARS-CoV-2 are symptomatic, even though most present only mild symptoms.Ana M. B. MenezesCesar G. VictoraFernando P. HartwigMariângela F. SilveiraBernardo L. HortaAluísio J. D. BarrosMarilia A. MesenburgFernando C. WehrmeisterLúcia C. PellandaOdir A. DellagostinCláudio J. StruchinerMarcelo N. BurattiniFernando C. BarrosPedro C. HallalNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Ana M. B. Menezes Cesar G. Victora Fernando P. Hartwig Mariângela F. Silveira Bernardo L. Horta Aluísio J. D. Barros Marilia A. Mesenburg Fernando C. Wehrmeister Lúcia C. Pellanda Odir A. Dellagostin Cláudio J. Struchiner Marcelo N. Burattini Fernando C. Barros Pedro C. Hallal High prevalence of symptoms among Brazilian subjects with antibodies against SARS-CoV-2
description	Abstract Since the beginning of the pandemic of COVID-19, there has been a widespread assumption that most infected persons are asymptomatic. Using data from the recent wave of the EPICOVID19 study, a nationwide household-based survey including 133 cities from all states of Brazil, we estimated the proportion of people with and without antibodies for SARS-CoV-2 who were asymptomatic, which symptoms were most frequently reported, number of symptoms and the association with socio-demographic characteristics. We tested 33,205 subjects using a rapid antibody test previously validated. Information was collected before participants received the test result. Out of 849 (2.7%) participants positive for SARS-CoV-2 antibodies, only 12.1% (95% CI 10.1–14.5) reported no symptoms, compared to 42.2% (95% CI 41.7–42.8) among those negative. The largest difference between the two groups was observed for changes in smell/taste (56.5% versus 9.1%, a 6.2-fold difference). Changes in smell/taste, fever and body aches were most likely to predict positive tests as suggested by recursive partitioning tree analysis. Among individuals without any of these three symptoms, only 0.8% tested positive, compared to 18.3% of those with both fever and changes in smell or taste. Most subjects with antibodies against SARS-CoV-2 are symptomatic, even though most present only mild symptoms.
format	article
author	Ana M. B. Menezes Cesar G. Victora Fernando P. Hartwig Mariângela F. Silveira Bernardo L. Horta Aluísio J. D. Barros Marilia A. Mesenburg Fernando C. Wehrmeister Lúcia C. Pellanda Odir A. Dellagostin Cláudio J. Struchiner Marcelo N. Burattini Fernando C. Barros Pedro C. Hallal
author_facet	Ana M. B. Menezes Cesar G. Victora Fernando P. Hartwig Mariângela F. Silveira Bernardo L. Horta Aluísio J. D. Barros Marilia A. Mesenburg Fernando C. Wehrmeister Lúcia C. Pellanda Odir A. Dellagostin Cláudio J. Struchiner Marcelo N. Burattini Fernando C. Barros Pedro C. Hallal
author_sort	Ana M. B. Menezes
title	High prevalence of symptoms among Brazilian subjects with antibodies against SARS-CoV-2
title_short	High prevalence of symptoms among Brazilian subjects with antibodies against SARS-CoV-2
title_full	High prevalence of symptoms among Brazilian subjects with antibodies against SARS-CoV-2
title_fullStr	High prevalence of symptoms among Brazilian subjects with antibodies against SARS-CoV-2
title_full_unstemmed	High prevalence of symptoms among Brazilian subjects with antibodies against SARS-CoV-2
title_sort	high prevalence of symptoms among brazilian subjects with antibodies against sars-cov-2
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/b4dbffcd6e78489f849ed91d1a9ca705
work_keys_str_mv	AT anambmenezes highprevalenceofsymptomsamongbraziliansubjectswithantibodiesagainstsarscov2 AT cesargvictora highprevalenceofsymptomsamongbraziliansubjectswithantibodiesagainstsarscov2 AT fernandophartwig highprevalenceofsymptomsamongbraziliansubjectswithantibodiesagainstsarscov2 AT mariangelafsilveira highprevalenceofsymptomsamongbraziliansubjectswithantibodiesagainstsarscov2 AT bernardolhorta highprevalenceofsymptomsamongbraziliansubjectswithantibodiesagainstsarscov2 AT aluisiojdbarros highprevalenceofsymptomsamongbraziliansubjectswithantibodiesagainstsarscov2 AT mariliaamesenburg highprevalenceofsymptomsamongbraziliansubjectswithantibodiesagainstsarscov2 AT fernandocwehrmeister highprevalenceofsymptomsamongbraziliansubjectswithantibodiesagainstsarscov2 AT luciacpellanda highprevalenceofsymptomsamongbraziliansubjectswithantibodiesagainstsarscov2 AT odiradellagostin highprevalenceofsymptomsamongbraziliansubjectswithantibodiesagainstsarscov2 AT claudiojstruchiner highprevalenceofsymptomsamongbraziliansubjectswithantibodiesagainstsarscov2 AT marcelonburattini highprevalenceofsymptomsamongbraziliansubjectswithantibodiesagainstsarscov2 AT fernandocbarros highprevalenceofsymptomsamongbraziliansubjectswithantibodiesagainstsarscov2 AT pedrochallal highprevalenceofsymptomsamongbraziliansubjectswithantibodiesagainstsarscov2
_version_	1718379608433229824

High prevalence of symptoms among Brazilian subjects with antibodies against SARS-CoV-2

Ejemplares similares