Association of Periaortic Fat and Abdominal Visceral Fat with Coronary Artery Atherosclerosis in Chinese Middle Aged and Elderly Patients Undergoing Computed Tomography Coronary Angiography

Background and Aims: Coronary artery disease (CAD) is usually caused by atherosclerosis, which is associated with general obesity and stronger associations with localized ectopic fat depots have been reported. We measured body ectopic fat distribution in Chinese patients to determine the association...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Jingqi Zhu, Zhangwei Yang, Xiaolin Li, Xiaoli Chen, Jingjiang Pi, Tao Zhuang, Jie Liu, Gang Li, Sheng Peng, Lin Zhang, Qi Zhang, Paul Chan, Brian Tomlinson, Huimin Fan, Liang Zheng, Zhongmin Liu, Yuzhen Zhang
Formato:	article
Lenguaje:	EN
Publicado:	Ubiquity Press 2021
Materias:	body ectopic fat distribution periaortic fat visceral fat atherosclerosis coronary artery disease Diseases of the circulatory (Cardiovascular) system RC666-701 Public aspects of medicine RA1-1270
Acceso en línea:	https://doaj.org/article/b4ddbaeef2ab441b8d5552cc217956a3
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:b4ddbaeef2ab441b8d5552cc217956a3
record_format	dspace
spelling	oai:doaj.org-article:b4ddbaeef2ab441b8d5552cc217956a32021-11-08T08:07:54ZAssociation of Periaortic Fat and Abdominal Visceral Fat with Coronary Artery Atherosclerosis in Chinese Middle Aged and Elderly Patients Undergoing Computed Tomography Coronary Angiography2211-817910.5334/gh.1078https://doaj.org/article/b4ddbaeef2ab441b8d5552cc217956a32021-10-01T00:00:00Zhttps://globalheartjournal.com/articles/1078https://doaj.org/toc/2211-8179Background and Aims: Coronary artery disease (CAD) is usually caused by atherosclerosis, which is associated with general obesity and stronger associations with localized ectopic fat depots have been reported. We measured body ectopic fat distribution in Chinese patients to determine the association with coronary artery atherosclerosis (CA). Methods: Patients undergoing coronary computed tomography angiography (CCTA) who agreed to participate in the study (n = 750, 50.4% men, mean age 64.8 years) had cardiovascular disease and risk assessment. Body ectopic fat depots were measured from CT and their association with CA, determined from CCTA, was evaluated by univariate and multivariate logistic regression models. Results: CAD with CA (CAD-CA) was present in 57.2% of participants with CAD of moderate/severe CA (CAD-msCA) present in 23.5% and both were significantly more frequent in men than in women. Overall, men had greater body mass index (BMI) but there was no difference in waist circumference (WC) between genders. However, significantly higher visceral adipose tissue (VAT) and periaortic fat volume (PAFV) were observed in men, whereas women had significantly higher abdominal subcutaneous adipose tissue (SAT). With increasing age, there was a significant decline in BMI, WC and SAT in men, but a significant increase of WC and VAT, PAFV and epicardial fat volume (EFV) in women. A high proportion of non-calcified plaques was observed in CAD-CA, 55.3% in CAD of minimal/mild CA (CAD-mmCA) with 38.7% exclusively non-calcified plaques, and 59.7% in CAD-msCA with multiple type plaques containing non-calcified ones. Multivariate logistic regression showed a significant association of PAFV with CAD-CA and CAD-msCA that was independent of general obesity and clinical risk factors, and independent of abdominal obesity in the highest PAFV quartile patients. VATA was associated with an increased prevalence of CAD-msCA in the patients in the upper 2 VATA quartiles that was independent of clinical risk factors and both general and abdominal obesity. Conclusions: We found age and gender differences of body ectopic fat distribution in Chinese patients with higher VAT and PAFV in men and higher SAT in women. With increased age, there was a decline of WC and SAT in men but not in women and an increase in WC, VAT and PAFV in women but not in men. PAFV was significantly associated with overall CAD-CA and CAD-msCA, while VAT was associated with CAD-msCA.Jingqi ZhuZhangwei YangXiaolin LiXiaoli ChenJingjiang PiTao ZhuangJie LiuGang LiSheng PengLin ZhangQi ZhangPaul ChanBrian TomlinsonHuimin FanLiang ZhengZhongmin LiuYuzhen ZhangUbiquity Pressarticlebody ectopic fat distributionperiaortic fatvisceral fatatherosclerosiscoronary artery diseaseDiseases of the circulatory (Cardiovascular) systemRC666-701Public aspects of medicineRA1-1270ENGlobal Heart, Vol 16, Iss 1 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	body ectopic fat distribution periaortic fat visceral fat atherosclerosis coronary artery disease Diseases of the circulatory (Cardiovascular) system RC666-701 Public aspects of medicine RA1-1270
spellingShingle	body ectopic fat distribution periaortic fat visceral fat atherosclerosis coronary artery disease Diseases of the circulatory (Cardiovascular) system RC666-701 Public aspects of medicine RA1-1270 Jingqi Zhu Zhangwei Yang Xiaolin Li Xiaoli Chen Jingjiang Pi Tao Zhuang Jie Liu Gang Li Sheng Peng Lin Zhang Qi Zhang Paul Chan Brian Tomlinson Huimin Fan Liang Zheng Zhongmin Liu Yuzhen Zhang Association of Periaortic Fat and Abdominal Visceral Fat with Coronary Artery Atherosclerosis in Chinese Middle Aged and Elderly Patients Undergoing Computed Tomography Coronary Angiography
description	Background and Aims: Coronary artery disease (CAD) is usually caused by atherosclerosis, which is associated with general obesity and stronger associations with localized ectopic fat depots have been reported. We measured body ectopic fat distribution in Chinese patients to determine the association with coronary artery atherosclerosis (CA). Methods: Patients undergoing coronary computed tomography angiography (CCTA) who agreed to participate in the study (n = 750, 50.4% men, mean age 64.8 years) had cardiovascular disease and risk assessment. Body ectopic fat depots were measured from CT and their association with CA, determined from CCTA, was evaluated by univariate and multivariate logistic regression models. Results: CAD with CA (CAD-CA) was present in 57.2% of participants with CAD of moderate/severe CA (CAD-msCA) present in 23.5% and both were significantly more frequent in men than in women. Overall, men had greater body mass index (BMI) but there was no difference in waist circumference (WC) between genders. However, significantly higher visceral adipose tissue (VAT) and periaortic fat volume (PAFV) were observed in men, whereas women had significantly higher abdominal subcutaneous adipose tissue (SAT). With increasing age, there was a significant decline in BMI, WC and SAT in men, but a significant increase of WC and VAT, PAFV and epicardial fat volume (EFV) in women. A high proportion of non-calcified plaques was observed in CAD-CA, 55.3% in CAD of minimal/mild CA (CAD-mmCA) with 38.7% exclusively non-calcified plaques, and 59.7% in CAD-msCA with multiple type plaques containing non-calcified ones. Multivariate logistic regression showed a significant association of PAFV with CAD-CA and CAD-msCA that was independent of general obesity and clinical risk factors, and independent of abdominal obesity in the highest PAFV quartile patients. VATA was associated with an increased prevalence of CAD-msCA in the patients in the upper 2 VATA quartiles that was independent of clinical risk factors and both general and abdominal obesity. Conclusions: We found age and gender differences of body ectopic fat distribution in Chinese patients with higher VAT and PAFV in men and higher SAT in women. With increased age, there was a decline of WC and SAT in men but not in women and an increase in WC, VAT and PAFV in women but not in men. PAFV was significantly associated with overall CAD-CA and CAD-msCA, while VAT was associated with CAD-msCA.
format	article
author	Jingqi Zhu Zhangwei Yang Xiaolin Li Xiaoli Chen Jingjiang Pi Tao Zhuang Jie Liu Gang Li Sheng Peng Lin Zhang Qi Zhang Paul Chan Brian Tomlinson Huimin Fan Liang Zheng Zhongmin Liu Yuzhen Zhang
author_facet	Jingqi Zhu Zhangwei Yang Xiaolin Li Xiaoli Chen Jingjiang Pi Tao Zhuang Jie Liu Gang Li Sheng Peng Lin Zhang Qi Zhang Paul Chan Brian Tomlinson Huimin Fan Liang Zheng Zhongmin Liu Yuzhen Zhang
author_sort	Jingqi Zhu
title	Association of Periaortic Fat and Abdominal Visceral Fat with Coronary Artery Atherosclerosis in Chinese Middle Aged and Elderly Patients Undergoing Computed Tomography Coronary Angiography
title_short	Association of Periaortic Fat and Abdominal Visceral Fat with Coronary Artery Atherosclerosis in Chinese Middle Aged and Elderly Patients Undergoing Computed Tomography Coronary Angiography
title_full	Association of Periaortic Fat and Abdominal Visceral Fat with Coronary Artery Atherosclerosis in Chinese Middle Aged and Elderly Patients Undergoing Computed Tomography Coronary Angiography
title_fullStr	Association of Periaortic Fat and Abdominal Visceral Fat with Coronary Artery Atherosclerosis in Chinese Middle Aged and Elderly Patients Undergoing Computed Tomography Coronary Angiography
title_full_unstemmed	Association of Periaortic Fat and Abdominal Visceral Fat with Coronary Artery Atherosclerosis in Chinese Middle Aged and Elderly Patients Undergoing Computed Tomography Coronary Angiography
title_sort	association of periaortic fat and abdominal visceral fat with coronary artery atherosclerosis in chinese middle aged and elderly patients undergoing computed tomography coronary angiography
publisher	Ubiquity Press
publishDate	2021
url	https://doaj.org/article/b4ddbaeef2ab441b8d5552cc217956a3
work_keys_str_mv	AT jingqizhu associationofperiaorticfatandabdominalvisceralfatwithcoronaryarteryatherosclerosisinchinesemiddleagedandelderlypatientsundergoingcomputedtomographycoronaryangiography AT zhangweiyang associationofperiaorticfatandabdominalvisceralfatwithcoronaryarteryatherosclerosisinchinesemiddleagedandelderlypatientsundergoingcomputedtomographycoronaryangiography AT xiaolinli associationofperiaorticfatandabdominalvisceralfatwithcoronaryarteryatherosclerosisinchinesemiddleagedandelderlypatientsundergoingcomputedtomographycoronaryangiography AT xiaolichen associationofperiaorticfatandabdominalvisceralfatwithcoronaryarteryatherosclerosisinchinesemiddleagedandelderlypatientsundergoingcomputedtomographycoronaryangiography AT jingjiangpi associationofperiaorticfatandabdominalvisceralfatwithcoronaryarteryatherosclerosisinchinesemiddleagedandelderlypatientsundergoingcomputedtomographycoronaryangiography AT taozhuang associationofperiaorticfatandabdominalvisceralfatwithcoronaryarteryatherosclerosisinchinesemiddleagedandelderlypatientsundergoingcomputedtomographycoronaryangiography AT jieliu associationofperiaorticfatandabdominalvisceralfatwithcoronaryarteryatherosclerosisinchinesemiddleagedandelderlypatientsundergoingcomputedtomographycoronaryangiography AT gangli associationofperiaorticfatandabdominalvisceralfatwithcoronaryarteryatherosclerosisinchinesemiddleagedandelderlypatientsundergoingcomputedtomographycoronaryangiography AT shengpeng associationofperiaorticfatandabdominalvisceralfatwithcoronaryarteryatherosclerosisinchinesemiddleagedandelderlypatientsundergoingcomputedtomographycoronaryangiography AT linzhang associationofperiaorticfatandabdominalvisceralfatwithcoronaryarteryatherosclerosisinchinesemiddleagedandelderlypatientsundergoingcomputedtomographycoronaryangiography AT qizhang associationofperiaorticfatandabdominalvisceralfatwithcoronaryarteryatherosclerosisinchinesemiddleagedandelderlypatientsundergoingcomputedtomographycoronaryangiography AT paulchan associationofperiaorticfatandabdominalvisceralfatwithcoronaryarteryatherosclerosisinchinesemiddleagedandelderlypatientsundergoingcomputedtomographycoronaryangiography AT briantomlinson associationofperiaorticfatandabdominalvisceralfatwithcoronaryarteryatherosclerosisinchinesemiddleagedandelderlypatientsundergoingcomputedtomographycoronaryangiography AT huiminfan associationofperiaorticfatandabdominalvisceralfatwithcoronaryarteryatherosclerosisinchinesemiddleagedandelderlypatientsundergoingcomputedtomographycoronaryangiography AT liangzheng associationofperiaorticfatandabdominalvisceralfatwithcoronaryarteryatherosclerosisinchinesemiddleagedandelderlypatientsundergoingcomputedtomographycoronaryangiography AT zhongminliu associationofperiaorticfatandabdominalvisceralfatwithcoronaryarteryatherosclerosisinchinesemiddleagedandelderlypatientsundergoingcomputedtomographycoronaryangiography AT yuzhenzhang associationofperiaorticfatandabdominalvisceralfatwithcoronaryarteryatherosclerosisinchinesemiddleagedandelderlypatientsundergoingcomputedtomographycoronaryangiography
_version_	1718442845600219136

Association of Periaortic Fat and Abdominal Visceral Fat with Coronary Artery Atherosclerosis in Chinese Middle Aged and Elderly Patients Undergoing Computed Tomography Coronary Angiography

Ejemplares similares