Cryo-EM structure of a light chain-derived amyloid fibril from a patient with systemic AL amyloidosis

Systemic AL amyloidosis is caused by misfolding of immunoglobulin light chains and is one of the most frequently occurring forms of systemic amyloidosis. Here the authors present the 3.3 Å cryo-EM structure of a λ1 AL amyloid fibril that was isolated from an explanted human heart.

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Autores principales:	Lynn Radamaker, Yin-Hsi Lin, Karthikeyan Annamalai, Stefanie Huhn, Ute Hegenbart, Stefan O. Schönland, Günter Fritz, Matthias Schmidt, Marcus Fändrich
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/b4de0969a221446794222489fd2110f9
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spelling	oai:doaj.org-article:b4de0969a221446794222489fd2110f92021-12-02T16:57:32ZCryo-EM structure of a light chain-derived amyloid fibril from a patient with systemic AL amyloidosis10.1038/s41467-019-09032-02041-1723https://doaj.org/article/b4de0969a221446794222489fd2110f92019-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-09032-0https://doaj.org/toc/2041-1723Systemic AL amyloidosis is caused by misfolding of immunoglobulin light chains and is one of the most frequently occurring forms of systemic amyloidosis. Here the authors present the 3.3 Å cryo-EM structure of a λ1 AL amyloid fibril that was isolated from an explanted human heart.Lynn RadamakerYin-Hsi LinKarthikeyan AnnamalaiStefanie HuhnUte HegenbartStefan O. SchönlandGünter FritzMatthias SchmidtMarcus FändrichNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-8 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Lynn Radamaker Yin-Hsi Lin Karthikeyan Annamalai Stefanie Huhn Ute Hegenbart Stefan O. Schönland Günter Fritz Matthias Schmidt Marcus Fändrich Cryo-EM structure of a light chain-derived amyloid fibril from a patient with systemic AL amyloidosis
description	Systemic AL amyloidosis is caused by misfolding of immunoglobulin light chains and is one of the most frequently occurring forms of systemic amyloidosis. Here the authors present the 3.3 Å cryo-EM structure of a λ1 AL amyloid fibril that was isolated from an explanted human heart.
format	article
author	Lynn Radamaker Yin-Hsi Lin Karthikeyan Annamalai Stefanie Huhn Ute Hegenbart Stefan O. Schönland Günter Fritz Matthias Schmidt Marcus Fändrich
author_facet	Lynn Radamaker Yin-Hsi Lin Karthikeyan Annamalai Stefanie Huhn Ute Hegenbart Stefan O. Schönland Günter Fritz Matthias Schmidt Marcus Fändrich
author_sort	Lynn Radamaker
title	Cryo-EM structure of a light chain-derived amyloid fibril from a patient with systemic AL amyloidosis
title_short	Cryo-EM structure of a light chain-derived amyloid fibril from a patient with systemic AL amyloidosis
title_full	Cryo-EM structure of a light chain-derived amyloid fibril from a patient with systemic AL amyloidosis
title_fullStr	Cryo-EM structure of a light chain-derived amyloid fibril from a patient with systemic AL amyloidosis
title_full_unstemmed	Cryo-EM structure of a light chain-derived amyloid fibril from a patient with systemic AL amyloidosis
title_sort	cryo-em structure of a light chain-derived amyloid fibril from a patient with systemic al amyloidosis
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/b4de0969a221446794222489fd2110f9
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Cryo-EM structure of a light chain-derived amyloid fibril from a patient with systemic AL amyloidosis

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