Genome-Wide Association Study of Body Weight Traits in Inner Mongolia Cashmere Goats
Objective: Body weight is an important economic trait for a goat, which greatly affects animal growth and survival. The purpose of this study was to identify genes associated with birth weight (BW), weaning weight (WW), and yearling weight (YW).Materials and Methods: In this study, a genome-wide ass...
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Frontiers Media S.A.
2021
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oai:doaj.org-article:b4e209033c434d80b0bb3ce33dba03d62021-12-02T01:24:43ZGenome-Wide Association Study of Body Weight Traits in Inner Mongolia Cashmere Goats2297-176910.3389/fvets.2021.752746https://doaj.org/article/b4e209033c434d80b0bb3ce33dba03d62021-12-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fvets.2021.752746/fullhttps://doaj.org/toc/2297-1769Objective: Body weight is an important economic trait for a goat, which greatly affects animal growth and survival. The purpose of this study was to identify genes associated with birth weight (BW), weaning weight (WW), and yearling weight (YW).Materials and Methods: In this study, a genome-wide association study (GWAS) of BW, WW, and YW was determined using the GGP_Goat_70K single-nucleotide polymorphism (SNP) chip in 1,920 Inner Mongolia cashmere goats.Results: We discovered that 21 SNPs were significantly associated with BW on the genome-wide levels. These SNPs were located in 10 genes, e.g., Mitogen-Activated Protein Kinase 3 (MAPK3), LIM domain binding 2 (LDB2), and low-density lipoprotein receptor-related protein 1B (LRP1B), which may be related to muscle growth and development in Inner Mongolia Cashmere goats. Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analysis revealed that these genes were significantly enriched in the regulation of actin cytoskeleton and phospholipase D signaling pathway etc.Conclusion: In summary, this study will improve the marker-assisted breeding of Inner Mongolia cashmere goats and the molecular mechanisms of important economic traits.Lei ZhangLei ZhangFenghong WangGong GaoXiaochun YanHongfu LiuZhihong LiuZhihong LiuZhihong LiuZhihong LiuZhixin WangZhixin WangZhixin WangLibing HeQi LvZhiying WangRuijun WangYanjun ZhangYanjun ZhangYanjun ZhangYanjun ZhangJinquan LiJinquan LiJinquan LiJinquan LiRui SuFrontiers Media S.A.articleInner Mongolia cashmere goatsgenome-wide association studyGGP_Goat_70K SNP chipbirth weight (BW)weaning weight (WW)yearling weight (YW)Veterinary medicineSF600-1100ENFrontiers in Veterinary Science, Vol 8 (2021) |
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DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Inner Mongolia cashmere goats genome-wide association study GGP_Goat_70K SNP chip birth weight (BW) weaning weight (WW) yearling weight (YW) Veterinary medicine SF600-1100 |
| spellingShingle |
Inner Mongolia cashmere goats genome-wide association study GGP_Goat_70K SNP chip birth weight (BW) weaning weight (WW) yearling weight (YW) Veterinary medicine SF600-1100 Lei Zhang Lei Zhang Fenghong Wang Gong Gao Xiaochun Yan Hongfu Liu Zhihong Liu Zhihong Liu Zhihong Liu Zhihong Liu Zhixin Wang Zhixin Wang Zhixin Wang Libing He Qi Lv Zhiying Wang Ruijun Wang Yanjun Zhang Yanjun Zhang Yanjun Zhang Yanjun Zhang Jinquan Li Jinquan Li Jinquan Li Jinquan Li Rui Su Genome-Wide Association Study of Body Weight Traits in Inner Mongolia Cashmere Goats |
| description |
Objective: Body weight is an important economic trait for a goat, which greatly affects animal growth and survival. The purpose of this study was to identify genes associated with birth weight (BW), weaning weight (WW), and yearling weight (YW).Materials and Methods: In this study, a genome-wide association study (GWAS) of BW, WW, and YW was determined using the GGP_Goat_70K single-nucleotide polymorphism (SNP) chip in 1,920 Inner Mongolia cashmere goats.Results: We discovered that 21 SNPs were significantly associated with BW on the genome-wide levels. These SNPs were located in 10 genes, e.g., Mitogen-Activated Protein Kinase 3 (MAPK3), LIM domain binding 2 (LDB2), and low-density lipoprotein receptor-related protein 1B (LRP1B), which may be related to muscle growth and development in Inner Mongolia Cashmere goats. Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analysis revealed that these genes were significantly enriched in the regulation of actin cytoskeleton and phospholipase D signaling pathway etc.Conclusion: In summary, this study will improve the marker-assisted breeding of Inner Mongolia cashmere goats and the molecular mechanisms of important economic traits. |
| format |
article |
| author |
Lei Zhang Lei Zhang Fenghong Wang Gong Gao Xiaochun Yan Hongfu Liu Zhihong Liu Zhihong Liu Zhihong Liu Zhihong Liu Zhixin Wang Zhixin Wang Zhixin Wang Libing He Qi Lv Zhiying Wang Ruijun Wang Yanjun Zhang Yanjun Zhang Yanjun Zhang Yanjun Zhang Jinquan Li Jinquan Li Jinquan Li Jinquan Li Rui Su |
| author_facet |
Lei Zhang Lei Zhang Fenghong Wang Gong Gao Xiaochun Yan Hongfu Liu Zhihong Liu Zhihong Liu Zhihong Liu Zhihong Liu Zhixin Wang Zhixin Wang Zhixin Wang Libing He Qi Lv Zhiying Wang Ruijun Wang Yanjun Zhang Yanjun Zhang Yanjun Zhang Yanjun Zhang Jinquan Li Jinquan Li Jinquan Li Jinquan Li Rui Su |
| author_sort |
Lei Zhang |
| title |
Genome-Wide Association Study of Body Weight Traits in Inner Mongolia Cashmere Goats |
| title_short |
Genome-Wide Association Study of Body Weight Traits in Inner Mongolia Cashmere Goats |
| title_full |
Genome-Wide Association Study of Body Weight Traits in Inner Mongolia Cashmere Goats |
| title_fullStr |
Genome-Wide Association Study of Body Weight Traits in Inner Mongolia Cashmere Goats |
| title_full_unstemmed |
Genome-Wide Association Study of Body Weight Traits in Inner Mongolia Cashmere Goats |
| title_sort |
genome-wide association study of body weight traits in inner mongolia cashmere goats |
| publisher |
Frontiers Media S.A. |
| publishDate |
2021 |
| url |
https://doaj.org/article/b4e209033c434d80b0bb3ce33dba03d6 |
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