Targeted delivery of Tet1 peptide functionalized polymersomes to the rat cochlear nerve

Ya Zhang1, Weikai Zhang1*, Alexander H Johnston2*, Tracey A Newman3, Ilmari Pyykk&ouml;1, Jing Zou1 1Department of Otolaryngology, University of Tampere, Medical School, Tampere, Finland; 2Centre for Biological Sciences, 3Clinical Neurosciences, University of Southampton, Southampton, UK*The...

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Autores principales:	Zhang Y, Zhang W, Johnston AH, Newman TA, Pyykk&ouml; I, Zou J
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2012
Materias:	Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/b4e243e8bc3f423baa243ed9cf5e6e92
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spelling	oai:doaj.org-article:b4e243e8bc3f423baa243ed9cf5e6e922021-12-02T04:23:48ZTargeted delivery of Tet1 peptide functionalized polymersomes to the rat cochlear nerve1176-91141178-2013https://doaj.org/article/b4e243e8bc3f423baa243ed9cf5e6e922012-02-01T00:00:00Zhttp://www.dovepress.com/targeted-delivery-of-tet1-peptide-functionalized-polymersomes-to-the-r-a9333https://doaj.org/toc/1176-9114https://doaj.org/toc/1178-2013Ya Zhang1, Weikai Zhang1, Alexander H Johnston2, Tracey A Newman3, Ilmari Pyykk&ouml;1, Jing Zou1 1Department of Otolaryngology, University of Tampere, Medical School, Tampere, Finland; 2Centre for Biological Sciences, 3Clinical Neurosciences, University of Southampton, Southampton, UK*These authors are co-contributorsAbstract: Polymersomes are nanosized vesicles formed from amphiphilic block copolymers, and have been identified as potential drug delivery vehicles to the inner ear. The aim of this study was to provide targeting to specific cells within the inner ear by functionalizing the polymersome surface with Tet1 peptide sequence. Tet1 peptide specifically binds to the trisialoganglioside clostridial toxin receptor on neurons and was expected to target the polymersomes toward the cochlear nerve. The Tet1 functionalized PEG-b-PCL polymersomes were administered using routine drug delivery routes: transtympanic injection and cochleostomy. Delivery via cochleostomy of Tet1 functionalized polymersomes resulted in cochlear nerve targeting; in contrast this was not seen after transtympanic injection.Keywords: nanoparticles, peptide, round window membrane, nerve fibers, spiral ganglion cell, drug deliveryZhang YZhang WJohnston AHNewman TAPyykk&ouml; IZou JDove Medical PressarticleMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol 2012, Iss default, Pp 1015-1022 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine (General) R5-920
spellingShingle	Medicine (General) R5-920 Zhang Y Zhang W Johnston AH Newman TA Pyykk&ouml; I Zou J Targeted delivery of Tet1 peptide functionalized polymersomes to the rat cochlear nerve
description	Ya Zhang1, Weikai Zhang1, Alexander H Johnston2, Tracey A Newman3, Ilmari Pyykk&ouml;1, Jing Zou1 1Department of Otolaryngology, University of Tampere, Medical School, Tampere, Finland; 2Centre for Biological Sciences, 3Clinical Neurosciences, University of Southampton, Southampton, UK*These authors are co-contributorsAbstract: Polymersomes are nanosized vesicles formed from amphiphilic block copolymers, and have been identified as potential drug delivery vehicles to the inner ear. The aim of this study was to provide targeting to specific cells within the inner ear by functionalizing the polymersome surface with Tet1 peptide sequence. Tet1 peptide specifically binds to the trisialoganglioside clostridial toxin receptor on neurons and was expected to target the polymersomes toward the cochlear nerve. The Tet1 functionalized PEG-b-PCL polymersomes were administered using routine drug delivery routes: transtympanic injection and cochleostomy. Delivery via cochleostomy of Tet1 functionalized polymersomes resulted in cochlear nerve targeting; in contrast this was not seen after transtympanic injection.Keywords: nanoparticles, peptide, round window membrane, nerve fibers, spiral ganglion cell, drug delivery
format	article
author	Zhang Y Zhang W Johnston AH Newman TA Pyykk&ouml; I Zou J
author_facet	Zhang Y Zhang W Johnston AH Newman TA Pyykk&ouml; I Zou J
author_sort	Zhang Y
title	Targeted delivery of Tet1 peptide functionalized polymersomes to the rat cochlear nerve
title_short	Targeted delivery of Tet1 peptide functionalized polymersomes to the rat cochlear nerve
title_full	Targeted delivery of Tet1 peptide functionalized polymersomes to the rat cochlear nerve
title_fullStr	Targeted delivery of Tet1 peptide functionalized polymersomes to the rat cochlear nerve
title_full_unstemmed	Targeted delivery of Tet1 peptide functionalized polymersomes to the rat cochlear nerve
title_sort	targeted delivery of tet1 peptide functionalized polymersomes to the rat cochlear nerve
publisher	Dove Medical Press
publishDate	2012
url	https://doaj.org/article/b4e243e8bc3f423baa243ed9cf5e6e92
work_keys_str_mv	AT zhangy targeteddeliveryoftet1peptidefunctionalizedpolymersomestotheratcochlearnerve AT zhangw targeteddeliveryoftet1peptidefunctionalizedpolymersomestotheratcochlearnerve AT johnstonah targeteddeliveryoftet1peptidefunctionalizedpolymersomestotheratcochlearnerve AT newmanta targeteddeliveryoftet1peptidefunctionalizedpolymersomestotheratcochlearnerve AT pyykkampoumli targeteddeliveryoftet1peptidefunctionalizedpolymersomestotheratcochlearnerve AT zouj targeteddeliveryoftet1peptidefunctionalizedpolymersomestotheratcochlearnerve
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Targeted delivery of Tet1 peptide functionalized polymersomes to the rat cochlear nerve

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