The DOG 1 EXPRESSION IN DIFFERENTIAL DIAGNOSIS OF CHONDROBLASTOMAS AND ITS HISTOLOGICAL MIMICKERS

Objective: Chondroblastoma is rare benign cartilage forming tumor of bone predominantly in individuals less than 20 years of age. Recently immunohistochemical marker DOG 1 has been reported to help in the diagnosis in difficult cases where histological features overlap with other similar entities. C...

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Autores principales:	Maryam Nisar, Sajid Mushtaq, Usman Hassan, Noreen Akhtar, Muhammad Azam
Formato:	article
Lenguaje:	EN
Publicado:	Army Medical College Rawalpindi 2020
Materias:	chondroblastoma dog 1 giant cell tumor chondromyxoid fibroma immunohistochemical marker Medicine R Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/b4e3dc0e7d434ae69fa85fe735d43b3f
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spelling	oai:doaj.org-article:b4e3dc0e7d434ae69fa85fe735d43b3f2021-12-02T14:54:22ZThe DOG 1 EXPRESSION IN DIFFERENTIAL DIAGNOSIS OF CHONDROBLASTOMAS AND ITS HISTOLOGICAL MIMICKERSdoi.org/10.51253/pafmj.v70i6.25330030-96482411-8842https://doaj.org/article/b4e3dc0e7d434ae69fa85fe735d43b3f2020-12-01T00:00:00Zhttps://pafmj.org/index.php/PAFMJ/article/view/2533https://doaj.org/toc/0030-9648https://doaj.org/toc/2411-8842Objective: Chondroblastoma is rare benign cartilage forming tumor of bone predominantly in individuals less than 20 years of age. Recently immunohistochemical marker DOG 1 has been reported to help in the diagnosis in difficult cases where histological features overlap with other similar entities. Current study aims to assess the sensitivity and specificity of DOG 1 in the diagnosis of chondroblastomas. Study design: descriptive cross-sectional study Place and duration of study: The study was conducted from June 2015 to July 2017 in Department of Histopathology, Shaukat Khanum Memorial Cancer Hospital and Research Centre, Lahore, Pakistan. Patients and methods: Total fifty-two patients were included in this study including 19 chondroblastomas, 21 giant cell tumors and 12 chondromyxoid fibromas. DOG 1 antibody was applied on all the cases Results: DOG 1 was positive in 100 % of cases of chondroblastomas. However, intensity and proportion of staining pattern was variable among them. 78% (n=15) cases showed diffuse moderate to strong expression while 22% (n=4) cases showed focal weak expression. Only 10% (n=2) cases of giant cell tumors and 33% (n=4) of chondromyxoid fibromas expressed focal weak expression for DOG 1. Conclusions: This study confirms 100 % expression of DOG 1 in cases of chondroblastomas but intensity and proportion of staining pattern was variable. Therefore DOG 1 may prove to be a useful immunohistochemical marker for diagnosis of chondroblastomas in the future in difficult cases in correlation with histological and radiological features.Maryam NisarSajid MushtaqUsman HassanNoreen AkhtarMuhammad AzamArmy Medical College Rawalpindiarticlechondroblastomadog 1giant cell tumorchondromyxoid fibromaimmunohistochemical markerMedicineRMedicine (General)R5-920ENPakistan Armed Forces Medical Journal, Vol 70, Iss 6, Pp 1825-1829 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	chondroblastoma dog 1 giant cell tumor chondromyxoid fibroma immunohistochemical marker Medicine R Medicine (General) R5-920
spellingShingle	chondroblastoma dog 1 giant cell tumor chondromyxoid fibroma immunohistochemical marker Medicine R Medicine (General) R5-920 Maryam Nisar Sajid Mushtaq Usman Hassan Noreen Akhtar Muhammad Azam The DOG 1 EXPRESSION IN DIFFERENTIAL DIAGNOSIS OF CHONDROBLASTOMAS AND ITS HISTOLOGICAL MIMICKERS
description	Objective: Chondroblastoma is rare benign cartilage forming tumor of bone predominantly in individuals less than 20 years of age. Recently immunohistochemical marker DOG 1 has been reported to help in the diagnosis in difficult cases where histological features overlap with other similar entities. Current study aims to assess the sensitivity and specificity of DOG 1 in the diagnosis of chondroblastomas. Study design: descriptive cross-sectional study Place and duration of study: The study was conducted from June 2015 to July 2017 in Department of Histopathology, Shaukat Khanum Memorial Cancer Hospital and Research Centre, Lahore, Pakistan. Patients and methods: Total fifty-two patients were included in this study including 19 chondroblastomas, 21 giant cell tumors and 12 chondromyxoid fibromas. DOG 1 antibody was applied on all the cases Results: DOG 1 was positive in 100 % of cases of chondroblastomas. However, intensity and proportion of staining pattern was variable among them. 78% (n=15) cases showed diffuse moderate to strong expression while 22% (n=4) cases showed focal weak expression. Only 10% (n=2) cases of giant cell tumors and 33% (n=4) of chondromyxoid fibromas expressed focal weak expression for DOG 1. Conclusions: This study confirms 100 % expression of DOG 1 in cases of chondroblastomas but intensity and proportion of staining pattern was variable. Therefore DOG 1 may prove to be a useful immunohistochemical marker for diagnosis of chondroblastomas in the future in difficult cases in correlation with histological and radiological features.
format	article
author	Maryam Nisar Sajid Mushtaq Usman Hassan Noreen Akhtar Muhammad Azam
author_facet	Maryam Nisar Sajid Mushtaq Usman Hassan Noreen Akhtar Muhammad Azam
author_sort	Maryam Nisar
title	The DOG 1 EXPRESSION IN DIFFERENTIAL DIAGNOSIS OF CHONDROBLASTOMAS AND ITS HISTOLOGICAL MIMICKERS
title_short	The DOG 1 EXPRESSION IN DIFFERENTIAL DIAGNOSIS OF CHONDROBLASTOMAS AND ITS HISTOLOGICAL MIMICKERS
title_full	The DOG 1 EXPRESSION IN DIFFERENTIAL DIAGNOSIS OF CHONDROBLASTOMAS AND ITS HISTOLOGICAL MIMICKERS
title_fullStr	The DOG 1 EXPRESSION IN DIFFERENTIAL DIAGNOSIS OF CHONDROBLASTOMAS AND ITS HISTOLOGICAL MIMICKERS
title_full_unstemmed	The DOG 1 EXPRESSION IN DIFFERENTIAL DIAGNOSIS OF CHONDROBLASTOMAS AND ITS HISTOLOGICAL MIMICKERS
title_sort	dog 1 expression in differential diagnosis of chondroblastomas and its histological mimickers
publisher	Army Medical College Rawalpindi
publishDate	2020
url	https://doaj.org/article/b4e3dc0e7d434ae69fa85fe735d43b3f
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The DOG 1 EXPRESSION IN DIFFERENTIAL DIAGNOSIS OF CHONDROBLASTOMAS AND ITS HISTOLOGICAL MIMICKERS

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