An improved reduced-order model for pressure drop across arterial stenoses.

Quantification of pressure drop across stenotic arteries is a major element in the functional assessment of occlusive arterial disease. Accurate estimation of the pressure drop with a numerical model allows the calculation of Fractional Flow Reserve (FFR), which is a haemodynamic index employed for...

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Autores principales:	Konstantinos G Lyras, Jack Lee
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/b4e8e890ef7a4f349cd4af13adbb7fe6
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spelling	oai:doaj.org-article:b4e8e890ef7a4f349cd4af13adbb7fe62021-12-02T20:17:25ZAn improved reduced-order model for pressure drop across arterial stenoses.1932-620310.1371/journal.pone.0258047https://doaj.org/article/b4e8e890ef7a4f349cd4af13adbb7fe62021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0258047https://doaj.org/toc/1932-6203Quantification of pressure drop across stenotic arteries is a major element in the functional assessment of occlusive arterial disease. Accurate estimation of the pressure drop with a numerical model allows the calculation of Fractional Flow Reserve (FFR), which is a haemodynamic index employed for guiding coronary revascularisation. Its non-invasive evaluation would contribute to safer and cost-effective diseases management. In this work, we propose a new formulation of a reduced-order model of trans-stenotic pressure drop, based on a consistent theoretical analysis of the Navier-Stokes equation. The new formulation features a novel term that characterises the contribution of turbulence effect to pressure loss. Results from three-dimensional computational fluid dynamics (CFD) showed that the proposed model produces predictions that are significantly more accurate than the existing reduced-order models, for large and small symmetric and eccentric stenoses, covering mild to severe area reductions. FFR calculations based on the proposed model produced zero classification error for three classes comprising positive (≤ 0.75), negative (≥ 0.8) and intermediate (0.75 - 0.8) classes.Konstantinos G LyrasJack LeePublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 10, p e0258047 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Konstantinos G Lyras Jack Lee An improved reduced-order model for pressure drop across arterial stenoses.
description	Quantification of pressure drop across stenotic arteries is a major element in the functional assessment of occlusive arterial disease. Accurate estimation of the pressure drop with a numerical model allows the calculation of Fractional Flow Reserve (FFR), which is a haemodynamic index employed for guiding coronary revascularisation. Its non-invasive evaluation would contribute to safer and cost-effective diseases management. In this work, we propose a new formulation of a reduced-order model of trans-stenotic pressure drop, based on a consistent theoretical analysis of the Navier-Stokes equation. The new formulation features a novel term that characterises the contribution of turbulence effect to pressure loss. Results from three-dimensional computational fluid dynamics (CFD) showed that the proposed model produces predictions that are significantly more accurate than the existing reduced-order models, for large and small symmetric and eccentric stenoses, covering mild to severe area reductions. FFR calculations based on the proposed model produced zero classification error for three classes comprising positive (≤ 0.75), negative (≥ 0.8) and intermediate (0.75 - 0.8) classes.
format	article
author	Konstantinos G Lyras Jack Lee
author_facet	Konstantinos G Lyras Jack Lee
author_sort	Konstantinos G Lyras
title	An improved reduced-order model for pressure drop across arterial stenoses.
title_short	An improved reduced-order model for pressure drop across arterial stenoses.
title_full	An improved reduced-order model for pressure drop across arterial stenoses.
title_fullStr	An improved reduced-order model for pressure drop across arterial stenoses.
title_full_unstemmed	An improved reduced-order model for pressure drop across arterial stenoses.
title_sort	improved reduced-order model for pressure drop across arterial stenoses.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/b4e8e890ef7a4f349cd4af13adbb7fe6
work_keys_str_mv	AT konstantinosglyras animprovedreducedordermodelforpressuredropacrossarterialstenoses AT jacklee animprovedreducedordermodelforpressuredropacrossarterialstenoses AT konstantinosglyras improvedreducedordermodelforpressuredropacrossarterialstenoses AT jacklee improvedreducedordermodelforpressuredropacrossarterialstenoses
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An improved reduced-order model for pressure drop across arterial stenoses.

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