Structural basis for Ragulator functioning as a scaffold in membrane-anchoring of Rag GTPases and mTORC1

Activated Rag GTPases recruit mTORC1 to lysosomes. Here the authors present the crystal structure of the Ragulator complex and identify the binding sites for the Roadblock domains of Rag GTPases, which gives insights how Rag GTPases are tethered to the lysosomal membrane.

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Autores principales:	Tianlong Zhang, Rong Wang, Zhijing Wang, Xiangxiang Wang, Fang Wang, Jianping Ding
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/b4e9df9de3bc4569a620c6e7d018eab2
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spelling	oai:doaj.org-article:b4e9df9de3bc4569a620c6e7d018eab22021-12-02T14:40:56ZStructural basis for Ragulator functioning as a scaffold in membrane-anchoring of Rag GTPases and mTORC110.1038/s41467-017-01567-42041-1723https://doaj.org/article/b4e9df9de3bc4569a620c6e7d018eab22017-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-01567-4https://doaj.org/toc/2041-1723Activated Rag GTPases recruit mTORC1 to lysosomes. Here the authors present the crystal structure of the Ragulator complex and identify the binding sites for the Roadblock domains of Rag GTPases, which gives insights how Rag GTPases are tethered to the lysosomal membrane.Tianlong ZhangRong WangZhijing WangXiangxiang WangFang WangJianping DingNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-10 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Tianlong Zhang Rong Wang Zhijing Wang Xiangxiang Wang Fang Wang Jianping Ding Structural basis for Ragulator functioning as a scaffold in membrane-anchoring of Rag GTPases and mTORC1
description	Activated Rag GTPases recruit mTORC1 to lysosomes. Here the authors present the crystal structure of the Ragulator complex and identify the binding sites for the Roadblock domains of Rag GTPases, which gives insights how Rag GTPases are tethered to the lysosomal membrane.
format	article
author	Tianlong Zhang Rong Wang Zhijing Wang Xiangxiang Wang Fang Wang Jianping Ding
author_facet	Tianlong Zhang Rong Wang Zhijing Wang Xiangxiang Wang Fang Wang Jianping Ding
author_sort	Tianlong Zhang
title	Structural basis for Ragulator functioning as a scaffold in membrane-anchoring of Rag GTPases and mTORC1
title_short	Structural basis for Ragulator functioning as a scaffold in membrane-anchoring of Rag GTPases and mTORC1
title_full	Structural basis for Ragulator functioning as a scaffold in membrane-anchoring of Rag GTPases and mTORC1
title_fullStr	Structural basis for Ragulator functioning as a scaffold in membrane-anchoring of Rag GTPases and mTORC1
title_full_unstemmed	Structural basis for Ragulator functioning as a scaffold in membrane-anchoring of Rag GTPases and mTORC1
title_sort	structural basis for ragulator functioning as a scaffold in membrane-anchoring of rag gtpases and mtorc1
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/b4e9df9de3bc4569a620c6e7d018eab2
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Structural basis for Ragulator functioning as a scaffold in membrane-anchoring of Rag GTPases and mTORC1

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