Hexokinase-2 depletion inhibits glycolysis and induces oxidative phosphorylation in hepatocellular carcinoma and sensitizes to metformin

Hexokinase 2 (HK2) is selectively upregulated in hepatocellular carcinoma (HCC). Here the authors show that HK2 ablation decreases glycolysis and triggers oxidative phosphorylation (OXPHO) rendering HCC more susceptible to the OXPHO inhibitor metformin and to the FDA-approved drug sorafenib.

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Bibliographic Details
Main Authors:	Dannielle DeWaal, Veronique Nogueira, Alexander R. Terry, Krushna C. Patra, Sang-Min Jeon, Grace Guzman, Jennifer Au, Christopher P. Long, Maciek R. Antoniewicz, Nissim Hay
Format:	article
Language:	EN
Published:	Nature Portfolio 2018
Subjects:	Science Q
Online Access:	https://doaj.org/article/b4eb4726703e40cea6442db1aeb36e9f
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spelling	oai:doaj.org-article:b4eb4726703e40cea6442db1aeb36e9f2021-12-02T15:34:00ZHexokinase-2 depletion inhibits glycolysis and induces oxidative phosphorylation in hepatocellular carcinoma and sensitizes to metformin10.1038/s41467-017-02733-42041-1723https://doaj.org/article/b4eb4726703e40cea6442db1aeb36e9f2018-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-02733-4https://doaj.org/toc/2041-1723Hexokinase 2 (HK2) is selectively upregulated in hepatocellular carcinoma (HCC). Here the authors show that HK2 ablation decreases glycolysis and triggers oxidative phosphorylation (OXPHO) rendering HCC more susceptible to the OXPHO inhibitor metformin and to the FDA-approved drug sorafenib.Dannielle DeWaalVeronique NogueiraAlexander R. TerryKrushna C. PatraSang-Min JeonGrace GuzmanJennifer AuChristopher P. LongMaciek R. AntoniewiczNissim HayNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Dannielle DeWaal Veronique Nogueira Alexander R. Terry Krushna C. Patra Sang-Min Jeon Grace Guzman Jennifer Au Christopher P. Long Maciek R. Antoniewicz Nissim Hay Hexokinase-2 depletion inhibits glycolysis and induces oxidative phosphorylation in hepatocellular carcinoma and sensitizes to metformin
description	Hexokinase 2 (HK2) is selectively upregulated in hepatocellular carcinoma (HCC). Here the authors show that HK2 ablation decreases glycolysis and triggers oxidative phosphorylation (OXPHO) rendering HCC more susceptible to the OXPHO inhibitor metformin and to the FDA-approved drug sorafenib.
format	article
author	Dannielle DeWaal Veronique Nogueira Alexander R. Terry Krushna C. Patra Sang-Min Jeon Grace Guzman Jennifer Au Christopher P. Long Maciek R. Antoniewicz Nissim Hay
author_facet	Dannielle DeWaal Veronique Nogueira Alexander R. Terry Krushna C. Patra Sang-Min Jeon Grace Guzman Jennifer Au Christopher P. Long Maciek R. Antoniewicz Nissim Hay
author_sort	Dannielle DeWaal
title	Hexokinase-2 depletion inhibits glycolysis and induces oxidative phosphorylation in hepatocellular carcinoma and sensitizes to metformin
title_short	Hexokinase-2 depletion inhibits glycolysis and induces oxidative phosphorylation in hepatocellular carcinoma and sensitizes to metformin
title_full	Hexokinase-2 depletion inhibits glycolysis and induces oxidative phosphorylation in hepatocellular carcinoma and sensitizes to metformin
title_fullStr	Hexokinase-2 depletion inhibits glycolysis and induces oxidative phosphorylation in hepatocellular carcinoma and sensitizes to metformin
title_full_unstemmed	Hexokinase-2 depletion inhibits glycolysis and induces oxidative phosphorylation in hepatocellular carcinoma and sensitizes to metformin
title_sort	hexokinase-2 depletion inhibits glycolysis and induces oxidative phosphorylation in hepatocellular carcinoma and sensitizes to metformin
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/b4eb4726703e40cea6442db1aeb36e9f
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Hexokinase-2 depletion inhibits glycolysis and induces oxidative phosphorylation in hepatocellular carcinoma and sensitizes to metformin

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