The podoplanin-CLEC-2 axis inhibits inflammation in sepsis

The podoplanin-CLEC-2 axis inhibits inflammation in sepsis

Sepsis is a life-threatening condition where exaggerated inflammatory responses lead to severe tissue damage. Here, Rayes and colleagues show that the interaction between podoplanin and its receptor CLEC-2 on platelets plays a critical role in limiting inflammation during sepsis.

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Autores principales: Julie Rayes, Siân Lax, Surasak Wichaiyo, Stephanie K. Watson, Ying Di, Stephanie Lombard, Beata Grygielska, Stuart W. Smith, Kassiani Skordilis, Steve P. Watson
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
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Q
Acceso en línea:https://doaj.org/article/b4f263bdafe34009bf6c603e5a0f07a4
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spelling oai:doaj.org-article:b4f263bdafe34009bf6c603e5a0f07a42021-12-02T15:38:44ZThe podoplanin-CLEC-2 axis inhibits inflammation in sepsis10.1038/s41467-017-02402-62041-1723https://doaj.org/article/b4f263bdafe34009bf6c603e5a0f07a42017-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-02402-6https://doaj.org/toc/2041-1723Sepsis is a life-threatening condition where exaggerated inflammatory responses lead to severe tissue damage. Here, Rayes and colleagues show that the interaction between podoplanin and its receptor CLEC-2 on platelets plays a critical role in limiting inflammation during sepsis.Julie RayesSiân LaxSurasak WichaiyoStephanie K. WatsonYing DiStephanie LombardBeata GrygielskaStuart W. SmithKassiani SkordilisSteve P. WatsonNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-14 (2017)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Julie Rayes
Siân Lax
Surasak Wichaiyo
Stephanie K. Watson
Ying Di
Stephanie Lombard
Beata Grygielska
Stuart W. Smith
Kassiani Skordilis
Steve P. Watson
The podoplanin-CLEC-2 axis inhibits inflammation in sepsis
description Sepsis is a life-threatening condition where exaggerated inflammatory responses lead to severe tissue damage. Here, Rayes and colleagues show that the interaction between podoplanin and its receptor CLEC-2 on platelets plays a critical role in limiting inflammation during sepsis.
format article
author Julie Rayes
Siân Lax
Surasak Wichaiyo
Stephanie K. Watson
Ying Di
Stephanie Lombard
Beata Grygielska
Stuart W. Smith
Kassiani Skordilis
Steve P. Watson
author_facet Julie Rayes
Siân Lax
Surasak Wichaiyo
Stephanie K. Watson
Ying Di
Stephanie Lombard
Beata Grygielska
Stuart W. Smith
Kassiani Skordilis
Steve P. Watson
author_sort Julie Rayes
title The podoplanin-CLEC-2 axis inhibits inflammation in sepsis
title_short The podoplanin-CLEC-2 axis inhibits inflammation in sepsis
title_full The podoplanin-CLEC-2 axis inhibits inflammation in sepsis
title_fullStr The podoplanin-CLEC-2 axis inhibits inflammation in sepsis
title_full_unstemmed The podoplanin-CLEC-2 axis inhibits inflammation in sepsis
title_sort podoplanin-clec-2 axis inhibits inflammation in sepsis
publisher Nature Portfolio
publishDate 2017
url https://doaj.org/article/b4f263bdafe34009bf6c603e5a0f07a4
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