The podoplanin-CLEC-2 axis inhibits inflammation in sepsis

The podoplanin-CLEC-2 axis inhibits inflammation in sepsis

Sepsis is a life-threatening condition where exaggerated inflammatory responses lead to severe tissue damage. Here, Rayes and colleagues show that the interaction between podoplanin and its receptor CLEC-2 on platelets plays a critical role in limiting inflammation during sepsis.

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Bibliographic Details
Main Authors: Julie Rayes, Siân Lax, Surasak Wichaiyo, Stephanie K. Watson, Ying Di, Stephanie Lombard, Beata Grygielska, Stuart W. Smith, Kassiani Skordilis, Steve P. Watson
Format: article
Language:EN
Published: Nature Portfolio 2017
Subjects:
Science
Q
Online Access:https://doaj.org/article/b4f263bdafe34009bf6c603e5a0f07a4
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