Stromal hyaluronan accumulation is associated with low immune response and poor prognosis in pancreatic cancer

Abstract Hyaluronan (HA) accumulation has been associated with poor survival in various cancers, but the mechanisms for this phenomenon are still unclear. The aim of this study was to investigate the prognostic significance of stromal HA accumulation and its association with host immune response in...

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Autores principales:	Kyösti Tahkola, Maarit Ahtiainen, Jukka-Pekka Mecklin, Ilmo Kellokumpu, Johanna Laukkarinen, Markku Tammi, Raija Tammi, Juha P. Väyrynen, Jan Böhm
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/b4f44af321ba49f18edf717a8c6c488d
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spelling	oai:doaj.org-article:b4f44af321ba49f18edf717a8c6c488d2021-12-02T17:52:33ZStromal hyaluronan accumulation is associated with low immune response and poor prognosis in pancreatic cancer10.1038/s41598-021-91796-x2045-2322https://doaj.org/article/b4f44af321ba49f18edf717a8c6c488d2021-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-91796-xhttps://doaj.org/toc/2045-2322Abstract Hyaluronan (HA) accumulation has been associated with poor survival in various cancers, but the mechanisms for this phenomenon are still unclear. The aim of this study was to investigate the prognostic significance of stromal HA accumulation and its association with host immune response in pancreatic ductal adenocarcinoma (PDAC). The study material consisted of 101 radically treated patients for PDAC from a single geographical area. HA staining was evaluated using a HA-specific probe, and the patterns of CD3, CD8, CD73 and PD-L1 expression were evaluated using immunohistochemistry. HA staining intensity of tumour stromal areas was assessed digitally using QuPath. CD3- and CD8-based immune cell score (ICS) was determined. High-level stromal HA expression was significantly associated with poor disease-specific survival (p = 0.037) and overall survival (p = 0.013) In multivariate analysis, high-level stromal HA expression was an independent negative prognostic factor together with histopathological grade, TNM stage, CD73 positivity in tumour cells and low ICS. Moreover, high-level stromal HA expression was associated with low ICS (p = 0.017). In conclusion, stromal HA accumulation is associated with poor survival and low immune response in PDAC.Kyösti TahkolaMaarit AhtiainenJukka-Pekka MecklinIlmo KellokumpuJohanna LaukkarinenMarkku TammiRaija TammiJuha P. VäyrynenJan BöhmNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Kyösti Tahkola Maarit Ahtiainen Jukka-Pekka Mecklin Ilmo Kellokumpu Johanna Laukkarinen Markku Tammi Raija Tammi Juha P. Väyrynen Jan Böhm Stromal hyaluronan accumulation is associated with low immune response and poor prognosis in pancreatic cancer
description	Abstract Hyaluronan (HA) accumulation has been associated with poor survival in various cancers, but the mechanisms for this phenomenon are still unclear. The aim of this study was to investigate the prognostic significance of stromal HA accumulation and its association with host immune response in pancreatic ductal adenocarcinoma (PDAC). The study material consisted of 101 radically treated patients for PDAC from a single geographical area. HA staining was evaluated using a HA-specific probe, and the patterns of CD3, CD8, CD73 and PD-L1 expression were evaluated using immunohistochemistry. HA staining intensity of tumour stromal areas was assessed digitally using QuPath. CD3- and CD8-based immune cell score (ICS) was determined. High-level stromal HA expression was significantly associated with poor disease-specific survival (p = 0.037) and overall survival (p = 0.013) In multivariate analysis, high-level stromal HA expression was an independent negative prognostic factor together with histopathological grade, TNM stage, CD73 positivity in tumour cells and low ICS. Moreover, high-level stromal HA expression was associated with low ICS (p = 0.017). In conclusion, stromal HA accumulation is associated with poor survival and low immune response in PDAC.
format	article
author	Kyösti Tahkola Maarit Ahtiainen Jukka-Pekka Mecklin Ilmo Kellokumpu Johanna Laukkarinen Markku Tammi Raija Tammi Juha P. Väyrynen Jan Böhm
author_facet	Kyösti Tahkola Maarit Ahtiainen Jukka-Pekka Mecklin Ilmo Kellokumpu Johanna Laukkarinen Markku Tammi Raija Tammi Juha P. Väyrynen Jan Böhm
author_sort	Kyösti Tahkola
title	Stromal hyaluronan accumulation is associated with low immune response and poor prognosis in pancreatic cancer
title_short	Stromal hyaluronan accumulation is associated with low immune response and poor prognosis in pancreatic cancer
title_full	Stromal hyaluronan accumulation is associated with low immune response and poor prognosis in pancreatic cancer
title_fullStr	Stromal hyaluronan accumulation is associated with low immune response and poor prognosis in pancreatic cancer
title_full_unstemmed	Stromal hyaluronan accumulation is associated with low immune response and poor prognosis in pancreatic cancer
title_sort	stromal hyaluronan accumulation is associated with low immune response and poor prognosis in pancreatic cancer
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/b4f44af321ba49f18edf717a8c6c488d
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Stromal hyaluronan accumulation is associated with low immune response and poor prognosis in pancreatic cancer

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