Involvement of Gut Microbiota in the Development of Psoriasis Vulgaris

Objectives: Psoriasis is a common chronic recurrent dermatitis. Accumulating observations show gut microbiota dysbiosis in psoriasis. We intend to further investigate the relationship between intestinal microbiota and psoriasis development.Design: We first performed an epidemiological investigation...

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Autores principales:	Chaonan Sun, Ling Chen, Huan Yang, Hongjiang Sun, Zhen Xie, Bei Zhao, Xuemei Jiang, Bi Qin, Zhu Shen
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	psoriasis gut microbiota 16S rRNA sequencing gastrointestinal symptom fecal microbiota transfer Nutrition. Foods and food supply TX341-641
Acceso en línea:	https://doaj.org/article/b4fc706268c0484199b4daf628a61533
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spelling	oai:doaj.org-article:b4fc706268c0484199b4daf628a615332021-11-22T07:19:58ZInvolvement of Gut Microbiota in the Development of Psoriasis Vulgaris2296-861X10.3389/fnut.2021.761978https://doaj.org/article/b4fc706268c0484199b4daf628a615332021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fnut.2021.761978/fullhttps://doaj.org/toc/2296-861XObjectives: Psoriasis is a common chronic recurrent dermatitis. Accumulating observations show gut microbiota dysbiosis in psoriasis. We intend to further investigate the relationship between intestinal microbiota and psoriasis development.Design: We first performed an epidemiological investigation on differences of gastrointestinal discomfort symptoms between patients with psoriasis and general population. Then variation of gut microbiota in patients with psoriasis (un)treated with acitretin plus narrow-band ultraviolet B (NB-UVB) was analyzed by 16S rRNA sequencing. We last compared recovery status and vital cytokines (lesion and intestine) of mouse psoriasiform models, which were transplanted with fecal microbiota from patients with psoriasis or healthy controls.Results: (1) About 85.5% of patients with psoriasis vs. 58.1% of healthy controls presented with at least one gastrointestinal symptom. The prevalence of investigated symptoms (e.g., abdominal distension and constipation) were significantly higher in patients, compared with controls (p < 0.05). Passing flatus and constipation were significantly correlated with psoriasis (p < 0.05 in both cases). (2) The abundance of Ruminococcaceae family, Coprococcus_1 genus, and Blautia genus were decreased with psoriasis improvement (p < 0.05, respectively), which had been demonstrated significantly increased in psoriasis. (3) Mice receiving psoriatic microbes transplantation showed delayed recovery of psoriasiform dermatitis and less reduction of interleukin (IL)-17A than those receiving healthy microbiota or blank control (p < 0.05 and p < 0.01, respectively).Conclusion: Multiple evidence we provided here preliminarily demonstrates the involvement of gut microbiota in the different degree of psoriasis activity. The strategy based on overall microbial communities is expected to be a promising supplementary for long-term management of psoriasis.Chaonan SunLing ChenHuan YangHongjiang SunHongjiang SunZhen XieBei ZhaoXuemei JiangBi QinBi QinZhu ShenZhu ShenFrontiers Media S.A.articlepsoriasisgut microbiota16S rRNA sequencinggastrointestinal symptomfecal microbiota transferNutrition. Foods and food supplyTX341-641ENFrontiers in Nutrition, Vol 8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	psoriasis gut microbiota 16S rRNA sequencing gastrointestinal symptom fecal microbiota transfer Nutrition. Foods and food supply TX341-641
spellingShingle	psoriasis gut microbiota 16S rRNA sequencing gastrointestinal symptom fecal microbiota transfer Nutrition. Foods and food supply TX341-641 Chaonan Sun Ling Chen Huan Yang Hongjiang Sun Hongjiang Sun Zhen Xie Bei Zhao Xuemei Jiang Bi Qin Bi Qin Zhu Shen Zhu Shen Involvement of Gut Microbiota in the Development of Psoriasis Vulgaris
description	Objectives: Psoriasis is a common chronic recurrent dermatitis. Accumulating observations show gut microbiota dysbiosis in psoriasis. We intend to further investigate the relationship between intestinal microbiota and psoriasis development.Design: We first performed an epidemiological investigation on differences of gastrointestinal discomfort symptoms between patients with psoriasis and general population. Then variation of gut microbiota in patients with psoriasis (un)treated with acitretin plus narrow-band ultraviolet B (NB-UVB) was analyzed by 16S rRNA sequencing. We last compared recovery status and vital cytokines (lesion and intestine) of mouse psoriasiform models, which were transplanted with fecal microbiota from patients with psoriasis or healthy controls.Results: (1) About 85.5% of patients with psoriasis vs. 58.1% of healthy controls presented with at least one gastrointestinal symptom. The prevalence of investigated symptoms (e.g., abdominal distension and constipation) were significantly higher in patients, compared with controls (p < 0.05). Passing flatus and constipation were significantly correlated with psoriasis (p < 0.05 in both cases). (2) The abundance of Ruminococcaceae family, Coprococcus_1 genus, and Blautia genus were decreased with psoriasis improvement (p < 0.05, respectively), which had been demonstrated significantly increased in psoriasis. (3) Mice receiving psoriatic microbes transplantation showed delayed recovery of psoriasiform dermatitis and less reduction of interleukin (IL)-17A than those receiving healthy microbiota or blank control (p < 0.05 and p < 0.01, respectively).Conclusion: Multiple evidence we provided here preliminarily demonstrates the involvement of gut microbiota in the different degree of psoriasis activity. The strategy based on overall microbial communities is expected to be a promising supplementary for long-term management of psoriasis.
format	article
author	Chaonan Sun Ling Chen Huan Yang Hongjiang Sun Hongjiang Sun Zhen Xie Bei Zhao Xuemei Jiang Bi Qin Bi Qin Zhu Shen Zhu Shen
author_facet	Chaonan Sun Ling Chen Huan Yang Hongjiang Sun Hongjiang Sun Zhen Xie Bei Zhao Xuemei Jiang Bi Qin Bi Qin Zhu Shen Zhu Shen
author_sort	Chaonan Sun
title	Involvement of Gut Microbiota in the Development of Psoriasis Vulgaris
title_short	Involvement of Gut Microbiota in the Development of Psoriasis Vulgaris
title_full	Involvement of Gut Microbiota in the Development of Psoriasis Vulgaris
title_fullStr	Involvement of Gut Microbiota in the Development of Psoriasis Vulgaris
title_full_unstemmed	Involvement of Gut Microbiota in the Development of Psoriasis Vulgaris
title_sort	involvement of gut microbiota in the development of psoriasis vulgaris
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/b4fc706268c0484199b4daf628a61533
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Involvement of Gut Microbiota in the Development of Psoriasis Vulgaris

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