Brain structural correlates of autistic traits across the diagnostic divide: A grey matter and white matter microstructure study

Autism Spectrum Disorders (ASD) are a set of neurodevelopmental conditions characterised by difficulties in social interaction and communication as well as stereotyped and restricted patterns of interest. Autistic traits exist in a continuum across the general population, whilst the extreme end of t...

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Autores principales:	Varun Arunachalam Chandran, Christos Pliatsikas, Janina Neufeld, Garret O'Connell, Anthony Haffey, Vincent DeLuca, Bhismadev Chakrabarti
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	Autism spectrum disorders Autistic traits Grey matter White matter microstructure Structural MRI Diffusion Tensor Imaging Computer applications to medicine. Medical informatics R858-859.7 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/b4ffaedbc1b94683ad9b6052f510129d
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spelling	oai:doaj.org-article:b4ffaedbc1b94683ad9b6052f510129d2021-11-26T04:28:55ZBrain structural correlates of autistic traits across the diagnostic divide: A grey matter and white matter microstructure study2213-158210.1016/j.nicl.2021.102897https://doaj.org/article/b4ffaedbc1b94683ad9b6052f510129d2021-01-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2213158221003417https://doaj.org/toc/2213-1582Autism Spectrum Disorders (ASD) are a set of neurodevelopmental conditions characterised by difficulties in social interaction and communication as well as stereotyped and restricted patterns of interest. Autistic traits exist in a continuum across the general population, whilst the extreme end of this distribution is diagnosed as clinical ASD. While many studies have investigated brain structure in autism using a case-control design, few have used a dimensional approach. To add to this growing body of literature, we investigated the structural brain correlates of autistic traits in a mixed sample of adult participants (25 ASD and 66 neurotypicals; age: 18–60 years). We examined the relationship between regional brain volumes (using voxel-based morphometry and surface-based morphometry) and white matter microstructure properties (using Diffusion Tensor Imaging) and autistic traits (using Autism Spectrum Quotient). Our findings show grey matter differences in regions including the orbitofrontal cortex and lingual gyrus, and suggestive evidence for white matter microstructure differences in tracts including the superior longitudinal fasciculus being related to higher autistic traits. These grey matter and white matter microstructure findings from our study are consistent with previous reports and support the brain structural differences in ASD. These findings provide further support for shared aetiology for autistic traits across the diagnostic divide.Varun Arunachalam ChandranChristos PliatsikasJanina NeufeldGarret O'ConnellAnthony HaffeyVincent DeLucaBhismadev ChakrabartiElsevierarticleAutism spectrum disordersAutistic traitsGrey matterWhite matter microstructureStructural MRIDiffusion Tensor ImagingComputer applications to medicine. Medical informaticsR858-859.7Neurology. Diseases of the nervous systemRC346-429ENNeuroImage: Clinical, Vol 32, Iss , Pp 102897- (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Autism spectrum disorders Autistic traits Grey matter White matter microstructure Structural MRI Diffusion Tensor Imaging Computer applications to medicine. Medical informatics R858-859.7 Neurology. Diseases of the nervous system RC346-429
spellingShingle	Autism spectrum disorders Autistic traits Grey matter White matter microstructure Structural MRI Diffusion Tensor Imaging Computer applications to medicine. Medical informatics R858-859.7 Neurology. Diseases of the nervous system RC346-429 Varun Arunachalam Chandran Christos Pliatsikas Janina Neufeld Garret O'Connell Anthony Haffey Vincent DeLuca Bhismadev Chakrabarti Brain structural correlates of autistic traits across the diagnostic divide: A grey matter and white matter microstructure study
description	Autism Spectrum Disorders (ASD) are a set of neurodevelopmental conditions characterised by difficulties in social interaction and communication as well as stereotyped and restricted patterns of interest. Autistic traits exist in a continuum across the general population, whilst the extreme end of this distribution is diagnosed as clinical ASD. While many studies have investigated brain structure in autism using a case-control design, few have used a dimensional approach. To add to this growing body of literature, we investigated the structural brain correlates of autistic traits in a mixed sample of adult participants (25 ASD and 66 neurotypicals; age: 18–60 years). We examined the relationship between regional brain volumes (using voxel-based morphometry and surface-based morphometry) and white matter microstructure properties (using Diffusion Tensor Imaging) and autistic traits (using Autism Spectrum Quotient). Our findings show grey matter differences in regions including the orbitofrontal cortex and lingual gyrus, and suggestive evidence for white matter microstructure differences in tracts including the superior longitudinal fasciculus being related to higher autistic traits. These grey matter and white matter microstructure findings from our study are consistent with previous reports and support the brain structural differences in ASD. These findings provide further support for shared aetiology for autistic traits across the diagnostic divide.
format	article
author	Varun Arunachalam Chandran Christos Pliatsikas Janina Neufeld Garret O'Connell Anthony Haffey Vincent DeLuca Bhismadev Chakrabarti
author_facet	Varun Arunachalam Chandran Christos Pliatsikas Janina Neufeld Garret O'Connell Anthony Haffey Vincent DeLuca Bhismadev Chakrabarti
author_sort	Varun Arunachalam Chandran
title	Brain structural correlates of autistic traits across the diagnostic divide: A grey matter and white matter microstructure study
title_short	Brain structural correlates of autistic traits across the diagnostic divide: A grey matter and white matter microstructure study
title_full	Brain structural correlates of autistic traits across the diagnostic divide: A grey matter and white matter microstructure study
title_fullStr	Brain structural correlates of autistic traits across the diagnostic divide: A grey matter and white matter microstructure study
title_full_unstemmed	Brain structural correlates of autistic traits across the diagnostic divide: A grey matter and white matter microstructure study
title_sort	brain structural correlates of autistic traits across the diagnostic divide: a grey matter and white matter microstructure study
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/b4ffaedbc1b94683ad9b6052f510129d
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Brain structural correlates of autistic traits across the diagnostic divide: A grey matter and white matter microstructure study

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