A novel autophagy enhancer as a therapeutic agent against metabolic syndrome and diabetes

A novel autophagy enhancer as a therapeutic agent against metabolic syndrome and diabetes

Autophagy plays an important role in metabolic functions and increased autophagic activity may be beneficial for metabolic disorders. Here the authors screen a chemical library for enhancer of autophagic flux and identify small molecules that improve the metabolic profile by increasing lysosomial fu...

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Autores principales: Hyejin Lim, Yu-Mi Lim, Kook Hwan Kim, Young Eui Jeon, Kihyoun Park, Jinyoung Kim, Hui-Yun Hwang, Dong Jin Lee, Haushabhau Pagire, Ho Jeong Kwon, Jin Hee Ahn, Myung-Shik Lee
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
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Q
Acceso en línea:https://doaj.org/article/b5027a9d500c443aa7ee8732532b7ad0
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spelling oai:doaj.org-article:b5027a9d500c443aa7ee8732532b7ad02021-12-02T17:31:58ZA novel autophagy enhancer as a therapeutic agent against metabolic syndrome and diabetes10.1038/s41467-018-03939-w2041-1723https://doaj.org/article/b5027a9d500c443aa7ee8732532b7ad02018-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-03939-whttps://doaj.org/toc/2041-1723Autophagy plays an important role in metabolic functions and increased autophagic activity may be beneficial for metabolic disorders. Here the authors screen a chemical library for enhancer of autophagic flux and identify small molecules that improve the metabolic profile by increasing lysosomial functions.Hyejin LimYu-Mi LimKook Hwan KimYoung Eui JeonKihyoun ParkJinyoung KimHui-Yun HwangDong Jin LeeHaushabhau PagireHo Jeong KwonJin Hee AhnMyung-Shik LeeNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Hyejin Lim
Yu-Mi Lim
Kook Hwan Kim
Young Eui Jeon
Kihyoun Park
Jinyoung Kim
Hui-Yun Hwang
Dong Jin Lee
Haushabhau Pagire
Ho Jeong Kwon
Jin Hee Ahn
Myung-Shik Lee
A novel autophagy enhancer as a therapeutic agent against metabolic syndrome and diabetes
description Autophagy plays an important role in metabolic functions and increased autophagic activity may be beneficial for metabolic disorders. Here the authors screen a chemical library for enhancer of autophagic flux and identify small molecules that improve the metabolic profile by increasing lysosomial functions.
format article
author Hyejin Lim
Yu-Mi Lim
Kook Hwan Kim
Young Eui Jeon
Kihyoun Park
Jinyoung Kim
Hui-Yun Hwang
Dong Jin Lee
Haushabhau Pagire
Ho Jeong Kwon
Jin Hee Ahn
Myung-Shik Lee
author_facet Hyejin Lim
Yu-Mi Lim
Kook Hwan Kim
Young Eui Jeon
Kihyoun Park
Jinyoung Kim
Hui-Yun Hwang
Dong Jin Lee
Haushabhau Pagire
Ho Jeong Kwon
Jin Hee Ahn
Myung-Shik Lee
author_sort Hyejin Lim
title A novel autophagy enhancer as a therapeutic agent against metabolic syndrome and diabetes
title_short A novel autophagy enhancer as a therapeutic agent against metabolic syndrome and diabetes
title_full A novel autophagy enhancer as a therapeutic agent against metabolic syndrome and diabetes
title_fullStr A novel autophagy enhancer as a therapeutic agent against metabolic syndrome and diabetes
title_full_unstemmed A novel autophagy enhancer as a therapeutic agent against metabolic syndrome and diabetes
title_sort novel autophagy enhancer as a therapeutic agent against metabolic syndrome and diabetes
publisher Nature Portfolio
publishDate 2018
url https://doaj.org/article/b5027a9d500c443aa7ee8732532b7ad0
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