Blood tryptase and thymic stromal lymphopoietin levels predict the risk of exacerbation in severe asthma

Abstract Some patients with severe asthma experience exacerbations despite receiving multiple therapy. The risk of exacerbation and heterogeneous response to treatment may be associated with specific inflammatory molecules that are responsive or resistant to corticosteroids. We aimed to identify the...

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Autores principales:	Hsin-Kuo Ko, Shih-Lung Cheng, Ching-Hsiung Lin, Sheng-Hao Lin, Yi-Han Hsiao, Kang-Cheng Su, Chong-Jen Yu, Hao-Chien Wang, Chau-Chyun Sheu, Kuo-Chin Chiu, Diahn-Warng Perng
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/b505610b58c54b7e807528151f52ae31
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spelling	oai:doaj.org-article:b505610b58c54b7e807528151f52ae312021-12-02T16:45:31ZBlood tryptase and thymic stromal lymphopoietin levels predict the risk of exacerbation in severe asthma10.1038/s41598-021-86179-12045-2322https://doaj.org/article/b505610b58c54b7e807528151f52ae312021-04-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-86179-1https://doaj.org/toc/2045-2322Abstract Some patients with severe asthma experience exacerbations despite receiving multiple therapy. The risk of exacerbation and heterogeneous response to treatment may be associated with specific inflammatory molecules that are responsive or resistant to corticosteroids. We aimed to identify the independent factors predictive for the future risk of exacerbation in patients with severe asthma. In this multi-center prospective observational study, 132 patients with severe asthma were enrolled and divided into exacerbation (n = 52) and non-exacerbation (n = 80) groups on the basis of exacerbation rate after a 1-year follow-up period. We found that previous history of severe-to-serious exacerbation, baseline blood eosinophil counts (≥ 291cells/μL), and serum tryptase (≤ 1448 pg/mL) and thrymic stromal lymphopoietin (TSLP) levels (≥ 25 pg/mL) independently predicted the future development of exacerbation with adjusted odds ratios (AOR) of 3.27, 6.04, 2.53 and 8.67, respectively. Notably, the patients with high blood eosinophil counts and low tryptase levels were likely to have more exacerbations than those with low blood eosinophil counts and high tryptase levels (AOR 16.9). TSLP potentially played the pathogenic role across different asthma phenotypes. TSLP and tryptase levels may be implicated in steroid resistance and responsiveness in the asthma inflammatory process. High blood eosinophil counts and low serum tryptase levels predict a high probability of future asthma exacerbation.Hsin-Kuo KoShih-Lung ChengChing-Hsiung LinSheng-Hao LinYi-Han HsiaoKang-Cheng SuChong-Jen YuHao-Chien WangChau-Chyun SheuKuo-Chin ChiuDiahn-Warng PerngNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Hsin-Kuo Ko Shih-Lung Cheng Ching-Hsiung Lin Sheng-Hao Lin Yi-Han Hsiao Kang-Cheng Su Chong-Jen Yu Hao-Chien Wang Chau-Chyun Sheu Kuo-Chin Chiu Diahn-Warng Perng Blood tryptase and thymic stromal lymphopoietin levels predict the risk of exacerbation in severe asthma
description	Abstract Some patients with severe asthma experience exacerbations despite receiving multiple therapy. The risk of exacerbation and heterogeneous response to treatment may be associated with specific inflammatory molecules that are responsive or resistant to corticosteroids. We aimed to identify the independent factors predictive for the future risk of exacerbation in patients with severe asthma. In this multi-center prospective observational study, 132 patients with severe asthma were enrolled and divided into exacerbation (n = 52) and non-exacerbation (n = 80) groups on the basis of exacerbation rate after a 1-year follow-up period. We found that previous history of severe-to-serious exacerbation, baseline blood eosinophil counts (≥ 291cells/μL), and serum tryptase (≤ 1448 pg/mL) and thrymic stromal lymphopoietin (TSLP) levels (≥ 25 pg/mL) independently predicted the future development of exacerbation with adjusted odds ratios (AOR) of 3.27, 6.04, 2.53 and 8.67, respectively. Notably, the patients with high blood eosinophil counts and low tryptase levels were likely to have more exacerbations than those with low blood eosinophil counts and high tryptase levels (AOR 16.9). TSLP potentially played the pathogenic role across different asthma phenotypes. TSLP and tryptase levels may be implicated in steroid resistance and responsiveness in the asthma inflammatory process. High blood eosinophil counts and low serum tryptase levels predict a high probability of future asthma exacerbation.
format	article
author	Hsin-Kuo Ko Shih-Lung Cheng Ching-Hsiung Lin Sheng-Hao Lin Yi-Han Hsiao Kang-Cheng Su Chong-Jen Yu Hao-Chien Wang Chau-Chyun Sheu Kuo-Chin Chiu Diahn-Warng Perng
author_facet	Hsin-Kuo Ko Shih-Lung Cheng Ching-Hsiung Lin Sheng-Hao Lin Yi-Han Hsiao Kang-Cheng Su Chong-Jen Yu Hao-Chien Wang Chau-Chyun Sheu Kuo-Chin Chiu Diahn-Warng Perng
author_sort	Hsin-Kuo Ko
title	Blood tryptase and thymic stromal lymphopoietin levels predict the risk of exacerbation in severe asthma
title_short	Blood tryptase and thymic stromal lymphopoietin levels predict the risk of exacerbation in severe asthma
title_full	Blood tryptase and thymic stromal lymphopoietin levels predict the risk of exacerbation in severe asthma
title_fullStr	Blood tryptase and thymic stromal lymphopoietin levels predict the risk of exacerbation in severe asthma
title_full_unstemmed	Blood tryptase and thymic stromal lymphopoietin levels predict the risk of exacerbation in severe asthma
title_sort	blood tryptase and thymic stromal lymphopoietin levels predict the risk of exacerbation in severe asthma
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/b505610b58c54b7e807528151f52ae31
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Blood tryptase and thymic stromal lymphopoietin levels predict the risk of exacerbation in severe asthma

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