Role of Aortic Geometry on Stroke Propensity based on Simulations of Patient-Specific Models

Abstract Stroke is a life threatening event that is expected to more than double over the next 40 years. Atrial fibrillation (AF) has been reported as a strong independent risk factor for stroke. We have previously shown that a hemodynamic perturbation by AF or reduced cardiac output and cycle lengt...

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Autores principales:	Hyo Won Choi, Tong Luo, Jose A. Navia, Ghassan S. Kassab
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/b50655e112a64bf0a974d58ed21ea27b
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spelling	oai:doaj.org-article:b50655e112a64bf0a974d58ed21ea27b2021-12-02T12:30:18ZRole of Aortic Geometry on Stroke Propensity based on Simulations of Patient-Specific Models10.1038/s41598-017-06681-32045-2322https://doaj.org/article/b50655e112a64bf0a974d58ed21ea27b2017-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-06681-3https://doaj.org/toc/2045-2322Abstract Stroke is a life threatening event that is expected to more than double over the next 40 years. Atrial fibrillation (AF) has been reported as a strong independent risk factor for stroke. We have previously shown that a hemodynamic perturbation by AF or reduced cardiac output and cycle length may have a significant impact on clot trajectory and thus embolic stroke propensity through the left common carotid artery using an idealized aortic arch model. Here, we show the dependence of flow patterns and hence stroke propensity on geometry of patient-specific aortas. We performed computational fluid dynamics (CFD) simulations to determine the variations of AF-induced stroke propensity over various image-based patient-dependent aorta models. The results demonstrated that curvature pattern of aorta can play a determinant role in AF-induced stroke propensity alteration. Specifically, it was shown that the hemodynamic perturbation by AF considered led to substantial increase in stroke propensity (i.e., 2.5~3.8 fold elevation) for lower curvature angle <90° while the changes in stroke propensity by AF are negligible for higher curvature angle >90°. The present simulations suggest that aortic arch curvature is an important risk factor for embolic stroke which should be tested in future clinical trials.Hyo Won ChoiTong LuoJose A. NaviaGhassan S. KassabNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-9 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Hyo Won Choi Tong Luo Jose A. Navia Ghassan S. Kassab Role of Aortic Geometry on Stroke Propensity based on Simulations of Patient-Specific Models
description	Abstract Stroke is a life threatening event that is expected to more than double over the next 40 years. Atrial fibrillation (AF) has been reported as a strong independent risk factor for stroke. We have previously shown that a hemodynamic perturbation by AF or reduced cardiac output and cycle length may have a significant impact on clot trajectory and thus embolic stroke propensity through the left common carotid artery using an idealized aortic arch model. Here, we show the dependence of flow patterns and hence stroke propensity on geometry of patient-specific aortas. We performed computational fluid dynamics (CFD) simulations to determine the variations of AF-induced stroke propensity over various image-based patient-dependent aorta models. The results demonstrated that curvature pattern of aorta can play a determinant role in AF-induced stroke propensity alteration. Specifically, it was shown that the hemodynamic perturbation by AF considered led to substantial increase in stroke propensity (i.e., 2.5~3.8 fold elevation) for lower curvature angle <90° while the changes in stroke propensity by AF are negligible for higher curvature angle >90°. The present simulations suggest that aortic arch curvature is an important risk factor for embolic stroke which should be tested in future clinical trials.
format	article
author	Hyo Won Choi Tong Luo Jose A. Navia Ghassan S. Kassab
author_facet	Hyo Won Choi Tong Luo Jose A. Navia Ghassan S. Kassab
author_sort	Hyo Won Choi
title	Role of Aortic Geometry on Stroke Propensity based on Simulations of Patient-Specific Models
title_short	Role of Aortic Geometry on Stroke Propensity based on Simulations of Patient-Specific Models
title_full	Role of Aortic Geometry on Stroke Propensity based on Simulations of Patient-Specific Models
title_fullStr	Role of Aortic Geometry on Stroke Propensity based on Simulations of Patient-Specific Models
title_full_unstemmed	Role of Aortic Geometry on Stroke Propensity based on Simulations of Patient-Specific Models
title_sort	role of aortic geometry on stroke propensity based on simulations of patient-specific models
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/b50655e112a64bf0a974d58ed21ea27b
work_keys_str_mv	AT hyowonchoi roleofaorticgeometryonstrokepropensitybasedonsimulationsofpatientspecificmodels AT tongluo roleofaorticgeometryonstrokepropensitybasedonsimulationsofpatientspecificmodels AT joseanavia roleofaorticgeometryonstrokepropensitybasedonsimulationsofpatientspecificmodels AT ghassanskassab roleofaorticgeometryonstrokepropensitybasedonsimulationsofpatientspecificmodels
_version_	1718394418899189760

Role of Aortic Geometry on Stroke Propensity based on Simulations of Patient-Specific Models

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